This retrospective study aimed to develop and validate deep-learning-based models for grading clear cell renal cell carcinoma (ccRCC) patients. A cohort enrolling 706 patients (n = 706) with pathologically verified ccRCC was used in this study. A temporal split was applied to verify our models: the first 83.9% of the cases (years 2010–2017) for development and the last 16.1% (year 2018–2019) for validation (development cohort: n = 592; validation cohort: n = 114). Here, we demonstrated a deep learning(DL) framework initialized by a self-supervised pre-training method, developed with the addition of mixed loss strategy and sample reweighting to identify patients with high grade for ccRCC. Four types of DL networks were developed separately and further combined with different weights for better prediction. The single DL model achieved up to an area under curve (AUC) of 0.864 in the validation cohort, while the ensembled model yielded the best predictive performance with an AUC of 0.882. These findings confirms that our DL approach performs either favorably or comparably in terms of grade assessment of ccRCC with biopsies whilst enjoying the non-invasive and labor-saving property.

Personalized trip recommendation tries to recommend a sequence of point of interests (POIs) for a user. Most of existing studies search POIs only according to the popularity of POIs themselves. In fact, the routes among the POIs also have attractions to visitors, and some of these routes have high popularity. We term this kind of route as Attractive Route (AR), which brings extra user experience. In this paper, we study the attractive routes to improve personalized trip recommendation. To deal with the challenges of discovery and evaluation of ARs, we propose a personalized Trip Recommender with POIs and Attractive Route (TRAR). It discovers the attractive routes based on the popularity and the Gini coefficient of POIs, then it utilizes a gravity model in a category space to estimate the rating scores and preferences of the attractive routes. Based on that, TRAR recommends a trip with ARs to maximize user experience and leverage the tradeoff between the time cost and the user experience. The experimental results show the superiority of TRAR compared with other state-of-the-art methods.

The expression status of programmed cell death protein 1 (PD-1) in patients with hepatocellular carcinoma (HCC) is associated with the checkpoint blockade treatment responses of PD-1/PD-L1. Thus, accurately and preoperatively identifying the status of PD-1 has great clinical implications for constructing personalized treatment strategies. To investigate the preoperative predictive value of the transformer-based model for identifying the status of PD-1 expression, 93 HCC patients with 75 training cohorts (2859 images) and 18 testing cohorts (670 images) were included. We propose a transformer-based network architecture, ResTransNet, that efficiently employs convolutional neural networks (CNNs) and self-attention mechanisms to automatically acquire a persuasive feature to obtain a prediction score using a nonlinear classifier. The area under the curve, receiver operating characteristic curve, and decision curves were applied to evaluate the prediction model’s performance. Then, Kaplan–Meier survival analyses were applied to evaluate the overall survival (OS) and recurrence-free survival (RFS) in PD-1-positive and PD-1-negative patients. The proposed transformer-based model obtained an accuracy of 88.2% with a sensitivity of 88.5%, a specificity of 88.9%, and an area under the curve of 91.1% in the testing cohort.

In a convolutional neural network (CNN), dropout cannot work well because dropped information is not entirely obscured in convolutional layers where features are correlated spatially. Except for randomly discarding regions or channels, many approaches try to overcome this defect by dropping influential units. In this paper, we propose a non-random dropout method named FocusedDropout, aiming to make the network focus more on the target. In FocusedDropout, we use a simple but effective method to search for the target-related features, retain these features and discard others, which is contrary to the existing methods. We find that this novel method can improve network performance by making the network more target focused. Additionally, increasing the weight decay while using FocusedDropout can avoid overfitting and increase accuracy. Experimental results show that with a slight cost, 10% of batches employing FocusedDropout, can produce a nice performance boost over the baselines on multiple datasets of classification, including CIFAR10, CIFAR100 and Tiny ImageNet, and has a good versatility for different CNN models.

Alzheimer’s disease, a prevalent form of dementia, is a progressive, long-term and irreversible neurological disorder. With the growing elderly population, there has been a significant rise in the number of individuals affected by Alzheimer’s disease, which will bring serious social and economic burdens to countries all over the world. Therefore, it is crucial to identify and diagnose Alzheimer’s disease and its current disease stage promptly and accurately to facilitate prompt intervention and treatment. This paper proposes an ensemble model that combines the convolutional neural network (ResNet50, DenseNet121, EfficientNet_B0) and Transformer architectures (Vision Transformer, TransFG) to predict Alzheimer’s disease patients and their current disease stage. The ensemble model exhibits impressive classification accuracy, with 98.91% accuracy, a Micro Area Under the Curve (micro-AUC) of 0.9996, and a macro-AUC of 0.9995. And the ensemble model accurately differentiates Alzheimer’s disease cases and their current disease stages. The proposed ensemble model exhibits classification accuracies of 99.06%, 99.11%, 97.78%, and 100% for healthy control, very mild, mild, and moderate cases respectively. By utilizing this ensemble model, healthcare professionals can rely on a more accurate prediction tool for Alzheimer’s disease and its current disease stage, which enables them to devise personalized treatment plans and nursing measures for affected patients.