Dissipative self-assembly is a challenging but attractive field of supramolecular science, because it generally concerns complex systems but is more close to the self-assembly of living bodies. In this article, we realized dissipative self-assembly by coupling a supra-amphiphile with a chemical oscillator. The supra-amphiphile was fabricated with iodine and a double hydrophilic block copolymer containing PEG segments, as the non-covalent interaction between PEG and iodine could turn PEG hydrophobic, leading to the formation of the supra-amphiphile. The self-assembly and disassembly of the supra-amphiphile could be controlled by varying the concentration of iodine. Therefore, the dissipative self-assembly of the supra-amphiphile was realized when it was coupled with the IO₃ ⁻–NH₃OH⁺–OH⁻ chemical oscillator, which was able to produce iodine periodically. Meanwhile, the kinetic data of the self-assembly and disassembly of the supra-amphiphile could be estimated by the theoretical simulation of the chemical oscillations. This line of research promotes the self-assembly of supra-amphiphiles one step forward from thermodynamic statics to a dissipative system, and also suggests a new strategy to investigate the kinetics of stimuli-responsive molecular self-assembly.

Covalent organic frameworks (COFs) are a class of crystalline porous organic polymers with polygonal porosity and highly ordered structures. The most prominent feature of the COFs is their excellent crystallinity and highly ordered modifiable one-dimensional pores. Since the first report of them in 2005, COFs with various structures were successfully synthesized and their applications in a wide range of fields including gas storage, pollution removal, catalysis, and optoelectronics explored. In the meantime, COFs also exhibited good performance in chemical and biological sensing, because their highly ordered modifiable pores allowed the selective adsorption of the analytes, and the interaction between the analytes and the COFs’ skeletons may lead to a detectable change in the optical or electrical properties of the COFs. In this review, we firstly demonstrate the basic principles of COFs-based chemical and biological sensing, then briefly summarize the applications of COFs in sensing some substances of practical value, including some gases, ions, organic compounds, and biomolecules. Finally, we discuss the trends and the challenges of COFs-based chemical and biological sensing.

The detection of rare circulating tumour cells (CTCs) in patients' blood is crucial for the early diagnosis of cancer, highly precise cancer therapy and monitoring therapeutic outcomes in real time. In this study we have developed an efficient strategy to capture and detect CTCs from the blood of cancer patients using a benzoboric acid modified gold-plated polymeric substrate with a regular 3D surface array. Compared with the smooth substrate, the substrate with the surface 3D microarrays exhibited a higher capture efficiency, i.e. 3.8 times that afforded by the smooth substrate. Additionally, due to the reversible reaction between the benzoboric acid on the 3D microarray and the sialic acid on CTCs, our strategy allowed for easy detachment of the captured CTCs from the substrate without causing critical damage to the cells. This will be of benefit for gaining further access to these rare cells for downstream characterization. The proposed strategy provides several advantages, including enhanced capture efficiency, high sensitivity, low cost and recovery of isolated CTCs, and could become a promising platform for early stage diagnosis of cancer.