Panic disorder is one of the most common anxiety disorders and has a lifetime prevalence of 3-5%. Panic attacks can begin at any age, but commonly have their onset in early adulthood between the ages of 20 and 40 years. Naturalistic data has shown that panic disorder has a chronic and relapsing course. Panic disorder is reported to be associated with an increased risk of suicidal behavior and comorbid psychiatric diagnoses such as depression and substance abuse. Currently, recommended treatment modalities for panic disorder include the use of antidepressant pharmacotherapy and/or cognitive behavioral therapy. Paroxetine is unique among the selective serotonin reuptake inhibitors since, in addition to its effect on the CNS serotonergic neurotransmission, it also has mild noradrenergic properties demonstrated to be effective in the treatment of anxiety disorders and depression. Paroxetine treatment has the potential to cause weight gain and sexual dysfunction, primarily anorgasmia and ejaculatory dysfunction for the long term. In the short-term, treatment causes nausea, gastrointestinal disturbances, irritability, headaches and eating and sleeping difficulties. Paroxetine is an example of an selective serotonin reuptake inhibitor agent, which has been well studied in the treatment of panic disorder and is efficacious and well-tolerated. Paroxetine pharmacotherapy has been recommended to be continued for 1 year as specified in the treatment guidelines set by the American Psychiatric Association in the treatment of panic disorder.

The fractional advection–dispersion equation is used in groundwater hydrology for modeling the movements of contaminants/solute particles along with flowing groundwater at the seepage velocity in porous media. This model is used for the prediction of the transport of nonreactive dissolved contaminants in groundwater. This paper establishes the existence and the uniqueness of solutions represented as fractional bi-variate power series of some initial-value problems and boundary-value problems for the fractional advection–dispersion equation. Moreover, a method to approximate the solutions using fractional polynomials in two variables and to evaluate the errors in a suitable rectangle is designed. Illustrative examples showing the applicability of the theoretical results are presented.

Due to the increased development of urban areas and climate change, water resource management is gaining more attention. Among the most important aspects under scrutiny is improving the reliability of water resources. In this paper, the focus is on the dynamic modelling of a well field in EPANET. By dynamic modelling, we mean that the numerical model can adjust the water levels in the wells with respect to the extracted flow rate, according to the results of the hydrogeological study of the area. The operation of a well field must sometimes be realized at partial loads. In this latter case, all the duty points of the pumps in operation change and the flow rates may exceed the maximum allowed values, leading to the rapid clogging of the wells. The model and results obtained for different operating scenarios will be presented in the paper.