In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the active pharmaceutical ingredient to accomplish a desired therapeutic response. Over the past few decades, there has been exponential growth of many new classes of coordination polymers, and MOFs have gained popularity over other identified systems due to their higher biocompatibility and versatile loading capabilities. This review presents and assesses the most recent research, findings, and challenges associated with the use of MOFs as DDSs. Among the most commonly used MOFs for investigated-purpose MOFs, coordination polymers and metal complexes based on synthetic and natural polymers, are well known. Specific attention is given to the stimuli- and multistimuli-responsive MOFs-based DDSs. Of great interest in the COVID-19 pandemic is the use of MOFs for combination therapy and multimodal systems.

Background: Research interest in phosphonates metal organic frameworks (MOF) has increased extremely in the last two decades, because of theirs fascinating and complex topology and structural flexibility. In this paper we present a mathematical model for ligand/metal ion ratio of an octahedral (O_h) network of cobalt vinylphosphonate (Co(vP)·H₂O). Results: A recurrent relationship of the ratio between the number of ligands and the number of metal ions in a lamellar octahedral (O_h) network Co(vP)·H₂O, has been deducted by building the 3D network step by step using HyperChem 7.52 package. The mathematical relationship has been validated using X ray analysis, experimental thermogravimetric and elemental analysis data. Conclusions: Based on deducted recurrence relationship, we can conclude prior to perform X ray analysis, that in the case of a thermogravimetric analysis pointing a ratio between the number of metal ions and ligands number around 1, the 3D network will have a central metal ion that corresponds to a single ligand. This relation is valid for every type of supramolecular network with divalent metal central ion O_h coordinated and bring valuable information with low effort and cost.

Reducing the ecological impact of dyes through wastewater discharge into the environment is a challenge that must be addressed in textile wastewater pollution prevention. Congo red (CR) dye is widely used in experimental studies for textile wastewater treatment due to its high organic loads used in its preparation. The degradation of organic dyes of the CR type was investigated using the photocatalytic activity of functionalized polymers. We have employed photodegradation procedures for both polymer-supported glycine groups (Code: AP2) and polymer-supported glycine-Zn(II) (Code: AP2-Zn(II)). A photocatalysis efficiency of 89.2% was achieved for glycine pendant groups grafted on styrene-6.7% divinylbenzene copolymer (AP2) and 95.4% for the AP2-Zn(II) sample by using an initial concentration of CR of 15 mg/L, a catalyst concentration of 1 g/L, and 240 min of photocatalysis. The findings provided here have shown that the two materials (AP2 and AP2-Zn(II)) may be effectively employed in the heterogeneous photocatalysis method to remove CR from water. From the perspective of the degradation mechanism of CR, the two photocatalysts act similarly.