Zhipeng Cai

Dr. Zhipeng Cai

orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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20 June 2024 in IEEE Journal of Biomedical and Health Informatics
Verified
Journal Article
Closed access
HGHongxiang Gao
Hongxiang Gao
XWXingyao Wang
Xingyao Wang
Zhenghua ChenZhenghua Chen
Zhenghua Chen
MWMin Wu
Min Wu
ZCZhipeng Cai
Zhipeng Cai
CLChengyu Liu
Chengyu Liu
Automatic emotion recognition based on multichannel Electroencephalography (EEG) holds great potential in advancing human-computer interaction. However, several significant challenges persist in existing research on algorithmic emotion recognition. These challenges include the need for a robust model to effectively learn discriminative node attributes over long paths, the exploration of ambiguous topological information in EEG channels and effective frequency bands, and the mapping between intrinsic data qualities and provided labels. To address these challenges, this study introduces the distribution-based uncertainty method to represent spatial dependencies and temporal-spectral relativeness in EEG signals based on Graph Convolutional Network (GCN) architecture that adaptively assigns weights to functional aggregate node features, enabling effective long-path capturing while mitigating over-smoothing phenomena. Moreover, the graph mixup technique is employed to enhance latent connected edges and mitigate noisy label issues. Furthermore, we integrate the uncertainty learning method with deep GCN weights in a one-way learning fashion, termed Connectivity Uncertainty GCN (CU-GCN). We evaluate our approach on two widely used datasets, namely SEED and SEEDIV, for emotion recognition tasks. The experimental results demonstrate the superiority of our methodology over previous methods, yielding positive and significant improvements. Ablation studies confirm the substantial contributions of each component to the overall performance.

22 March 2022 in Biosensors
Verified
Journal Article
Open access
PDF file
ZCZhipeng Cai
Zhipeng Cai
TWTiantian Wang
Tiantian Wang
YSYumin Shen
Yumin Shen
YXYantao Xing
Yantao Xing
RYRuqiang Yan
Ruqiang Yan
CLChengyu Liu
Chengyu Liu
Premature ventricular contraction (PVC) is one of the common ventricular arrhythmias, which may cause stroke or sudden cardiac death. Automatic long-term electrocardiogram (ECG) analysis algorithms could provide diagnosis suggestion and even early warning for physicians. However, they are mutually exclusive in terms of robustness, generalization and low complexity. In this study, a novel PVC recognition algorithm that combines deep learning-based heartbeat template clusterer and expert system-based heartbeat classifier is proposed. A long short-term memory-based auto-encoder (LSTM-AE) network was used to extract features from ECG heartbeats for K-means clustering. Thus, the templates were constructed and determined based on clustering results. Finally, the PVC heartbeats were recognized based on a combination of multiple rules, including template matching and rhythm characteristics. Three quantitative parameters, sensitivity (Se), positive predictive value (P+) and accuracy (ACC), were used to evaluate the performances of the proposed method on the MIT-BIH Arrhythmia database and the St. Petersburg Institute of Cardiological Technics database. Se on the two test databases was 87.51% and 87.92%, respectively; P+ was 92.47% and 93.18%, respectively; and ACC was 98.63% and 97.89%, respectively. The PVC scores on the third China Physiological Signal Challenge 2020 training set and hidden test set were 36,256 and 46,706, respectively, which could rank first in the open-source codes. The results showed that the combination strategy of expert system and deep learning can provide new insights for robust and generalized PVC identification from long-term single-lead ECG recordings.

13 February 2024 in IEEE Transactions on Instrumentation and Measurement
Verified
Journal Article
Closed access
YSYumin Shen
Yumin Shen
ZCZhipeng Cai
Zhipeng Cai
Li ZhangLi Zhang
Li Zhang
Bor-Shing LinBor-Shing Lin
Bor-Shing Lin
JLJianqing Li
Jianqing Li
CLChengyu Liu
Chengyu Liu
Automatic detection of premature ventricular contractions (PVCs) is essential for early identification of cardiovascular abnormalities and reduction of clinical workload. As the most prevalent arrhythmia, PVCs can cause cardiac failure or sudden death. The difficulty resides in extracting features that effectively reflect the electrocardiogram (ECG) signals. Transition networks (TN), which represent the transition relationships between various phases of a time series, are advantageous for capturing temporal dynamics. Therefore, in order to recognize PVCs, each heartbeat was firstly split into serval segments; then their statistical properties were calculated for the sequence construction; finally, network topology related features were extracted from TN constructed by these sequences of statistical properties, and input into decision trees-based Gentleboost for PVC recognition. The algorithm was trained on MIT-BIH arrhythmia database (MIT-BIH-AR), and tested on St. Petersburg Institute of Cardiological Technics 12-lead arrhythmia database (INCART), wearable ECG database (WECG), and noise stress test database by four evaluation metrics: sensitivity, positive predictivity, F1-score (F1) and area under the curve (AUC). The proposed algorithm achieved an average F1 of 0.9784 and AUC of 0.9975 on MIT-BIH-AR, and proved good generalization ability on INCART and WECG with F1=0.9633 and 0.9467, AUC=0.9887 and 0.9755, respectively. The algorithm also exhibited robustness and noise immunity as evidenced by tests on sensitivity of R-wave peak offset and noise, and real-world daily life conditions. Overall, the proposed PVC detection algorithm based on TN theory offered high classification accuracy, strong robustness, and good generalization ability, with great potential for wearable mobile applications.

8 July 2024 in IEEE Transactions on Neural Systems and Rehabilitation Engineering
Verified
Journal Article
Open access
ZCZhipeng Cai
Zhipeng Cai
HGHongxiang Gao
Hongxiang Gao
MWMin Wu
Min Wu
JLJianqing Li
Jianqing Li
CLChengyu Liu
Chengyu Liu
In recent years, there has been a surge in interest regarding the intricate physiological interplay between the brain and the heart, particularly during emotional processing. This has led to the development of various signal processing techniques aimed at investigating Brain-Heart Interactions (BHI), reflecting a growing appreciation for their bidirectional communication and influence on each other. Our study contributes to this burgeoning field by adopting a network physiology approach, employing time-delay stability as a quantifiable metric to discern and measure the coupling strength between the brain and the heart, specifically during visual emotional elicitation. We extract and transform features from EEG and ECG signals into a 1 Hz format, facilitating the calculation of BHI coupling strength through stability analysis on their maximal cross-correlation. Notably, our investigation sheds light on the critical role played by low-frequency components in EEG, particularly in the $\delta $ , $\theta $ , and $\alpha $ bands, as essential mediators of information transmission during the complex processing of emotion-related stimuli by the brain. Furthermore, our analysis highlights the pivotal involvement of frontal pole regions, emphasizing the significance of $\delta $ - $\theta $ coupling in mediating emotional responses. Additionally, we observe significant arousal-dependent changes in the $\theta $ frequency band across different emotional states, particularly evident in the prefrontal cortex. By offering novel insights into the synchronized dynamics of cortical and heartbeat activities during emotional elicitation, our research enriches the expanding knowledge base in the field of neurophysiology and emotion research.

7 September 2022 in IEEE Transactions on Biomedical Engineering
Verified
Journal Article
Closed access
KDKejun Dong
Kejun Dong
Li ZhaoLi Zhao
Li Zhao
CZCairong Zou
Cairong Zou
ZCZhipeng Cai
Zhipeng Cai
CYChang Yan
Chang Yan
CLChengyu Liu
Chengyu Liu
Objective: ECG-derived respiration (EDR) is a low-cost and productive means for capturing respiratory activity. In particular, as the primary procedure in some cardiorespiratory-related studies, the quality of EDR is decisive for the performance of subsequent analyses. Approach: In this paper, we proposed a novel EDR method based on the feature derived from the first moment (mean frequency) of the power spectrum (FMS). After obtaining the EDR signal from the feature, we introduced the Interacting Multiple Model (IMM) smoother to enhance the similarity of the EDR signal to the reference respiration. The assessment of the approach consisted of two steps: 1) the performance of extracted feature was verified against R-peak misalignment and noise. 2) the enhancement of IMM smoother to EDR waveforms was evaluated based on waveform correlation and respiratory rate estimation. All the assessments were conducted under the Fantasia database and Drivers database. Results: The FMS improved robustness against R peak offsets compared to most established feature-based EDR algorithms, but a slight 5% improvement of waveform correlation against RR interval-based feature under accurate R peaks. The IMM smoother performed similarly with the Kalman filter in the static database but realized the enhancement of some extent of the EDR waveform in the ambulatory database. Significance: The proposed method investigated frequency domain mapping of ECG morphological changes caused by respiratory modulation and explained the EDR signal as a non-stationary time series, which provided a direction of better fitting the natural respiration process and enhancing the EDR waveform.

9 September 2022 in Frontiers in Physiology
Verified
Journal Article
Open access
ZCZhipeng Cai
Zhipeng Cai
HCHongyi Cheng
Hongyi Cheng
YXYantao Xing
Yantao Xing
FCFeifei Chen
Feifei Chen
YZYike Zhang
Yike Zhang
CCChang Cui
Chang Cui
Background: Autonomic nerve system (ANS) plays an important role in regulating cardiovascular function and cerebrovascular function. Traditional heart rate variation (HRV) and emerging skin sympathetic nerve activity (SKNA) analyses from ultra-short-time (UST) data cannot fully reveal neural activity, thereby quantitatively reflect ANS intensity.Methods: Electrocardiogram and SKNA from sixteen patients (seven cerebral hemorrhage (CH) patients and nine control group (CO) patients) were recorded using a portable device. Ten derived HRV (mean, standard deviation and root mean square difference of sinus RR intervals (NNmean, SDNN and RMSSD), ultra-low frequency (<0.003 Hz, uLF), very low frequency ([0.003 Hz, 0.04 Hz), vLF), low frequency ([0.04 Hz, 0.15 Hz), LF) and high frequency power ([0.15 Hz, 0.4 Hz), HF), ratio of LF to HF (LF/HF), the standard deviation of instantaneous beat-to-beat R-R interval variability (SD1), and approximate entropy (ApEn)) and ten visibility graph (VG) features (diameter (Dia), average node degree (aND), average shortest-path length (aSPL), clustering coefficient (CC), average closeness centrality (aCC), transitivity (Trans), average degree centrality (aDC), link density (LD), sMetric (sM) and graph energy (GE) of the constructed complex network) were compared on 5-min and UST segments to verify their validity and robustness in discriminating CH and CO under different data lengths. Besides, their potential for quantifying ANS-Load were also investigated.Results: The validation results of HRV and VG features in discriminating CH from CO showed that VG features were more clearly distinguishable between the two groups than HRV features. For effectiveness evaluation of analyzing ANS on UST segment, the NNmean, SDNN, RMSSD, LF, HF and LF/HF in HRV features and the CC, Trans, Dia and GE of VG features remained stable in both activated and inactivated segments across all data lengths. The capability of HRV and VG features in quantifying ANS-Load were evaluated and compared under different ANS-Load, the results showed that most HRV features (SDNN, LFHF, RMSSD, vLF, LF and HF) and almost all VG features were correlated to sympathetic nerve activity intensity.Conclusions: The proposed autonomic nervous activity analysis method based on VG and SKNA offers a new insight into ANS assessment in UST segments and ANS-Load quantification.