Gorka Orive

Dr. Gorka Orive

University of the Basque Country, Vitoria-Gasteiz, Spain
orcid

Research Focus & Metrics

Academic Career Length

26Years (2001-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2019 in Acta Biomaterialia
Verified
Journal Article
Closed access
AWAngela M. Wagner
Angela M. Wagner
JKJennifer M. Knipe
Jennifer M. Knipe
GOGorka Orive
Gorka Orive
NPNicholas A. Peppas
Nicholas A. Peppas

1 January 2003 in Nature Medicine
Verified
Journal Article
Closed access
GOGorka Orive
Gorka Orive
Rosa Maria HernandezRosa Maria Hernandez
Rosa Maria Hernandez
Alicia Rodríguez-GascónAlicia Rodríguez-Gascón
Alicia Rodríguez-Gascón
RCRiccardo Calafiore
Riccardo Calafiore
TCThomas M.S. Chang
Thomas M.S. Chang
José Luis PedrazJosé Luis Pedraz
José Luis Pedraz

14 June 2019 in Advanced Science
Verified
Journal Article
Open access
PDF file
STSepehr Talebian
Sepehr Talebian
Mehdi MehraliMehdi Mehrali
Mehdi Mehrali
Nayere TaebniaNayere Taebnia
Nayere Taebnia
Cristian Pablo PennisiCristian Pablo Pennisi
Cristian Pablo Pennisi
FKFiroz Babu Kadumudi
Firoz Babu Kadumudi
Alireza Dolatshahi-PirouzAlireza Dolatshahi-Pirouz
Alireza Dolatshahi-Pirouz
Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self‐healing remains unaddressed, and therefore most of the self‐healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self‐healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double‐network hydrogels is showing great promise as a feasible way to generate self‐healable hydrogels with the above‐mentioned attributes. Here, the recent progress in the development of multifunctional and self‐healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.

1 November 2007 in Biomaterials
Verified
Journal Article
Closed access
EAEduardo Anitua
Eduardo Anitua
MSMikel Sánchez
Mikel Sánchez
GOGorka Orive
Gorka Orive
IAIsabel Andia
Isabel Andia

1 May 2006 in Trends in Biotechnology
Verified
Journal Article
Closed access
EAEduardo Anitua
Eduardo Anitua
MSMikel Sánchez
Mikel Sánchez
ANAlan T. Nurden
Alan T. Nurden
PNPaquita Nurden
Paquita Nurden
GOGorka Orive
Gorka Orive
IAIsabel Andia
Isabel Andia

23 March 2020 in Pharmaceutics
Verified
Journal Article
Open access
PDF file
Mohamed HaiderMohamed Haider
Mohamed Haider
SAShifaa Abdin
Shifaa Abdin
LKLeena Kamal
Leena Kamal
GOGorka Orive
Gorka Orive
The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotechnology has revolutionized the pharmaceutical industry and attracted increasing attention as a significant means for optimizing the delivery of chemotherapeutic agents and enhancing their efficiency and safety profiles. Nanostructured lipid carriers (NLCs) are lipid-based formulations that have been broadly studied as drug delivery systems. They have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs) due to their enhanced physical stability, improved drug loading capacity, and biocompatibility. This review focuses on the latest advances in the use of NLCs as drug delivery systems and their preparation and characterization techniques with special emphasis on their applications as delivery systems for chemotherapeutic agents and different strategies for their use in tumor targeting.