Dumping of solid waste in the non-engineered landfill is very common in the developing countries. Among the different disadvantages of this kind of landfilling, leachate is the major concern to public health, which is a toxic byproduct generated from the landfill; and can percolate to the ground water and consequently migrate in surface water. Using systematic review on published data, the present study endeavors to compare the leachate contamination potential of four major landfills of Bangladesh, named Amin Bazar, Matuail, Mogla Bazar and Rowfabad; which are situated in 3 of the 6 big mega cities of Bangladesh and assessed the effects of leachate leakage on surrounding water body as well as on human health. This study, for the first time calculated the leachate pollution index (LPI) for the landfill sites of Bangladesh and found that the LPI of Matuail landfill site (19.81) is much higher which is comparable to some polluted landfill sites of India and Malaysia. The concentrations of several potentially toxic metals found in the surface and ground water in the vicinity of the landfill sites were above the maximum permissible limit values of department of Environment, Bangladesh and World Health Organization (WHO). The human health risk index for toxic heavy metals in different vegetables and rice grain showed high health risk potential for Pb, Cd, Ni, and Mn. The total carcinogenic risk for Ni and Pb are found very high in the edible plants near those landfill sites, suggesting the risk of Ni and Pb induced carcinogenesis by the consumption of those plants. The present conditions of surface, ground water and agriculture products near the landfill sites of Bangladesh are much frightening to the biota and local inhabitants.