The outcomes of patient care are improved by adequate knowledge, practical skills, and positive attitude. Currently, there is a lack of data on medical research activities among resident doctors in Saudi Arabia. This study aimed to evaluate the perception, barriers, and research attitudes among various residency programs running in different cities of Saudi Arabia. A total of 434 surgical and medical residents participated in the current study. A cross-sectional study encompassing multiple training centers in the eastern province of Saudi. Convenient sampling technique was used to include all the working training residents. A self-administered questionnaire was formulated for data collection. Descriptive statistics were employed to analyze the data. The mean age of the residents with various specialties was 27.83 ± 2.41 years. Approximately 61.7% had participated in research, while 38.3% had never participated in any research. A total of 26% of junior and 44% of senior residents have one publication only. While 11% of junior and 9% of senior residents have three publications or more. Inadequate facilities for research, lack of baseline research skills, and personal commitments were the reasons which over 60% of respondents had agreed on. Institutional reasons: lack of professional supervisor support and lack of research curriculum in the training program was reported by 308 (71%) and 305(70.3%) residents, respectively. A lack of interest for research was prevailed more in males (19%) compared to females (14%) (OR 1.43, 95% CI: 0.86–2.38, p-value 0.17). A subset of residents had one or three publications, while some had none. A lack of baseline research skills and inadequate facilities for scientific explorations, time, and funds were the main constraints among training residents. However, several residents had a positive attitude toward research but fewer publications. Thus, training in medical research methodology should be obligatory in the residency curriculum in all specialties. Further research is needed.

Introduction: Lower back pain is common worldwide and affects over 600,000 people annually, including teachers. The study aimed to investigate the prevalence of low back pain and disability among secondary school teachers in the Eastern Province of the Kingdom of Saudi Arabia.Materials and methods: This cross-sectional study included secondary school teachers in the eastern province of Saudi Arabia. 34 schools were selected using a multistage stratified sampling approach. Teachers were allotted randomly and proportionally to each school. Data was collected by anonymous questionnaire having three elements: sociodemographic and health-related questions, the Standardized Nordic Questionnaire, and the Oswestry Low Back Pain Disability Questionnaire. The anthropometric data was also included. Both unadjusted and adjusted logistic regression analyses were performed.Results: A total of 601 teachers participated in the study with 62.56% reported low back pain. The overall mean age was 40.31 ± 8.13 years. The male-to-female ratio was similar. Back pain was significantly higher among females than males (73.36 and 51.52%, respectively). Additionally, back pain will significantly increase when stress levels and the number of classes increases. A positive correlation was found between age with low back pain (p = 0.001).There was minimal disability in 64.63% of the 376 teachers who reported low back pain, moderate disability in 29.79%, and severe disability in 4.79%, and only three (0.8%) were considered crippled. Females were more frequently seen in moderate and crippled categories, and perceived stress levels generally increased mean disability scores. Age and female gender were revealed to be significant predictors of low back pain by logistic regression (adjusted odds ratio [OR] = 1.04, 95% confidence interval [CI] = 1.02–1.07) and (adjusted OR = 2.11, 95% CI = 1.45–3.05), respectively. The number of classes per week was also a significant predictor.Conclusion: This study adds to the epidemiological evidence that reveals a high prevalence of low back pain and disability among teachers. Identified risk factors in this study may also reinforce the importance of setting different interventions and preventive measures to reduce lower back pain risk.

Introduction: Psychological distress is common among medical students worldwide. However, psychological stigma remains a significant barrier to seeking help. This study explores the association between psychological distress, stigma, and attitudes toward help-seeking among medical students in the unique cultural context of Saudi Arabia. Methods: A cross-sectional study was conducted using an online survey distributed to medical students across Saudi Arabia, yielding 1,077 completed responses. Sociodemographic data were collected, along with responses to the Kessler Psychological Distress Scale (K6), the Stigma Scale for Receiving Psychological Help (SSRPH-A), and the Attitudes Toward Seeking Professional Psychological Help Scale (ATSPPH-SF-A). Data were analyzed using descriptive statistics, Spearman’s correlation, and factor analysis. Results: Overall, 32.2% of students reported low distress, 34.5% moderate distress, and 33.4% high distress. Female students exhibited higher distress but greater openness to seeking help, while males reported higher stigma. Lower GPA and income were associated with increased distress and reduced help-seeking attitudes. Regional variations were observed, with Najran reporting the highest distress, and Madinah and Qassim showing higher openness to help-seeking. Discussion: Findings are consistent with the international studies, indicating that stigma significantly hinders service utilization despite need. Cultural norms, socioeconomic status, and educational systems further shape attitudes. Digital healthcare transformation in Saudi Arabia offers opportunities to reduce stigma and expand access. Conclusion: Psychological distress and stigma remain prevalent among Saudi medical students, influenced by gender, socioeconomic, and regional factors. Targeted, culturally informed interventions are essential to reduce psychological stigma, promote awareness, and encourage positive help-seeking behaviors within academic environments.

Background: Physical activity is a known preventive measure for many worldwide public health issues. The purpose of this study is to assess the association between physical activity and the susceptibility to COVID-19 infection. Patients and Methods: This was a retrospective matched case–control study involving adult participants quarantined with IAU, Dammam, Saudi Arabia. The total randomized sample of study participants were 142, in which 73 of them were tested positive for COVID-19 test and matched for both age and sex with their respective healthy controls who tested negative for COVID-19 test to determine the risk associated with that exposure. Results: Several variables are assessed regarding their influence on the susceptibility of COVID-19 infection. Exactly half indicated that they were physically active (n = 71). Physical activity did not show any significant association with COVID-19 contraction (x²= 0.254, P= 0.614) nor self-rated level of physical activity (x²= 0.122, P= 0.727). Less than half of the participants who had contact with a COVID-19 patient within 14 days of admission to quarantine appeared to have a significantly higher incidence of positive COVID-19 swab results compared to those who did not (x²= 27.121, P= < 0.001). While third of the participants who indicated that they have had a contact with someone who have Respiratory symptoms or fever within 14 days before admission were tested positive for COVID-19. Participants with lower educational degrees are more likely to be infected with COVID-19. While the rest of the demographic variables appear to be not significantly related to the likelihood of being COVID-19 infected, these include gender, marital status, employment status, age, and BMI. Conclusion: The present study showed no significant association between physical activity and susceptibility to COVID-19 infection. We recommend a larger sample size to further clarify the relationship between other variables and susceptibility of COVID-19.

BACKGROUND Tirzepatide is effective for glycemic control and weight management in type 2 diabetes and obesity. Clinical trials have demonstrated tirzepatide's lower risk of acute kidney injury (AKI) compared with existing glucagon-like peptide-1 receptor agonists, along with benefits including reduced albuminuria and stable estimated glomerular filtration rate. Rare cases of AKI have been reported, potentially associated with dehydration from gastrointestinal side effects, polypharmacy, or comorbidities. We describe AKI in a non-diabetic, multimorbid patient after rapid tirzepatide dose escalation, underscoring the importance of identifying susceptible patient phenotypes. CASE REPORT A 66-year-old man with morbid obesity (body mass index 61.4 kg/m²), hypertension, prediabetes, hypothyroidism, and polypharmacy presented for weight management before bariatric surgery. Tirzepatide was initiated at 2.5 mg weekly and escalated to 12.5 mg over 4 months, resulting in weight loss of 35 kg. Preoperative evaluation revealed AKI, with a serum creatinine level of 2.4 mg/dL, potassium of 6.8 mmol/L, and metabolic acidosis (pH 7.31). Potential contributors included pharmacodynamic interactions with antihypertensive agents or dehydration secondary to gastrointestinal side effects. Management involved intensive care unit admission, antihyperkalemic therapy, intravenous fluids, and tirzepatide discontinuation. Renal function improved (creatinine 1.18 mg/dL) by discharge. CONCLUSIONS The AKI in this case may have resulted from the combination of rapid tirzepatide dose escalation, polypharmacy, and multimorbidity, potentially compounded by subclinical volume depletion or hemodynamic alterations. Clinicians should utilize standard titration schedules, closely monitor blood pressure and renal function, and exercise caution in patients with complex medication regimens to maximize tirzepatide's therapeutic benefits while minimizing renal risk.

Introduction: Tobacco use has changed since the onset of the coronavirus disease (COVID-19) pandemic. The effect of smoking on COVID-19 susceptibility has not yet been determined. In this study, we aimed to assess the association between smoking and COVID-19 susceptibility. Methods: This...