Groundwater is critical to the socioeconomic development of any region. Infiltration of surface water into the ground is influenced by a variety of factors such as soil pores, folds, fractures, faults, and joints, all of which contribute to groundwater recharge. Groundwater is an important source of freshwater in the drought-prone Pudukkottai district of Tamil Nadu, India. Therefore, the search for groundwater potential zones (GWPZs) is critical. The present study focuses on the investigation of potential groundwater zones using geospatial techniques. Geology, land use and land cover, geomorphology, soil, drainage density, lineament, and groundwater levels were obtained from state and non-state associations. ArcGIS version 10.8 was used to create all thematic layers and classified grids. The intensive use of groundwater in arid and semiarid regions is becoming a problem for the public to meet their freshwater needs. The condition of arid and semi-arid regions due to intensive groundwater extraction has become one of the most important environmental problems for the public. In this study, a powerful groundwater potential mapping technique was developed using integrated remote sensing data from GIS-AHP. Using AHP techniques, thematic layers for geology, geomorphology, and soil followed by drainage, drainage density and lineament, lineament density, slope, water level, and lithological parameters were created, classified, weighted, and integrated into a GIS environment. According to the results of the study, it is estimated that 14% of the groundwater potential in the study area is good, 49% is moderate and 36% is poor. A groundwater level map was used to verify the groundwater potential. In addition, the model was validated with a single-layer sensitivity analysis, which showed that geology was the most influential layer and water level was the least influential thematic layer. The low-potential areas identified on the groundwater potential map can be used for further study to identify ideal locations for artificial recharge. In low potential areas, the groundwater potential map can be used to find ideal locations for artificial recharge. The water table in the area must be raised by artificial recharge structures such as infiltration basins, recharge pits, and agricultural ponds. Artificial recharge structures such as infiltration basins, recharge pits, and agricultural ponds can be used for groundwater development in the low potential zones. The GWPZ map was successfully validated with three proxy data, such as the number of wells, groundwater level, and well density, obtained from well inventory information. The results of this study will improve our understanding of the geographic analysis of groundwater potential and help policy makers in this drought-prone area to create more sustainable water supply systems.