HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a new sensitive mitochondrial-targeting fluorescent probe.

A red fluorescent probe (Mito-V) with a long lifetime was designed to monitor viscosity changes with high selectivity and sensitivity. The fluorescence intensity and lifetime of Mito-V displayed a good relationship with the viscosity value, and Mito-V was successfully applied to sensing mitochondrial viscosity changes in living cells under different biological processes.

A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect the intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.

A red molecular probe for carbon monoxide (CO)-specific detection based on palladium-free mediated opening of spirolactam has been applied to establish a safe and powerful method to detect and image CO changes in biological systems.