Anthracyclines are chemotherapeutic agents frequently used in breast cancer (BC) treatment. Although it improves disease-free and overall survival, the use of anthracyclines is associated with a cumulative risk of cardiac toxicity. Preventive strategies to optimize cardiac health are needed and exercise is proposed as a potential non-pharmacological approach for counteracting anthracycline-related cardiotoxicity (ARC). Most of the data on the effects of exercise to reduce ACT are from animal studies, with only a few studies in a limited number of patients indicating beneficial effects. To better understand the effectiveness of exercise in the mitigation of ARC, clinical, real-world trials claim require a larger sample size and more accurate and valuable clinical biomarkers. In this study, we intend to include a large sample and investigate cardiac function through serial measures of biomarkers and imaging techniques. This protocol describes a two-arm, prospective, randomized controlled trial that will explore the cardioprotective effect of a structured exercise program in women with BC undergoing anthracycline-containing chemotherapy (ACT). Ninety adult women with early BC and recommended to receive ACT will be randomly assigned (1:1) to an intervention group or a control group. Patients allocated to the intervention group will perform a supervised exercise program three times per week, consisting of a combination of aerobic and resistance training with progressive intensity and volume, during the time period they receive ACT. The control group will receive standard BC care. Primary outcomes related to cardiac (dys)function will be circulating N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, resting left ventricular (LV) longitudinal strain, and resting LV ejection fraction. Secondary outcomes will include the assessment of resting blood pressure, resting heart rate (HR), resting HR variability (HRV), recovery HR, physical function outcomes, self-reported physical activity level, health-related quality of life, and fatigue. Data will be obtained at baseline (t0), after the end of anthracycline-treatment (t2), and 3 months after t2 (t3). Additionally, NT-proBNP will be measured 1–24 h prior to each anthracycline-treatment cycle (t1). The implementation of the present study design, using novel clinical biomarkers, will determine the effect of structured exercise interventions at mitigating ARC, with the overall aim of finding means to further improve BC care. ISRCTN, ISRCTN32617901 . Registered on 24 October 2018. Last updated on 11 January 2019.

Backpacks for transporting school loads are heavily utilized by children, and their mechanical advantages have been allowing children to transport heavy loads. These heavy loads may increase ground reaction forces (GRFs), which can have a negative effect on joints and bone health. The aim of this study was to investigate the effect of backpacks on the GRFs generated by children during walking, running, and jumping. Twenty-one children from the fifth (G-5, n = 9) and ninth (G-9, n = 12) grades walked, ran, and jumped over a force plate. When walking, the G-5 had GRF increments in the first (17.3%; p < 0.001) and second (15.4%; p < 0.001) peak magnitude, and in the total integral of the vertical force (20%; p < 0.001), compared to the control condition (i.e., no backpack), and the G-9 had increments of 10.4%, 9%, and 9% (p < 0.001), respectively. The G-9 did not prolong their total stance time (p > 0.05), unlike the G-5 (p = 0.001). When running, total stance time increased 15% (p < 0.001) and 8.5% (p < 0.001) proportionally to the relative load carried, in the G-5 and G-9, respectively. Peak GRF did not increase in any group when running or landing from a jump over an obstacle. It was found that GRF was affected by the backpack load when walking and running. However, when landing from a jump with the backpack, schoolchildren smoothed the landing by prolonging the reception time and thus avoiding GRF peak magnitudes.

After breast cancer diagnosis (BCD), localized breast cancer (BC) patients are treated with curative intent by several therapeutic modalities. Despite the benefit of those therapies, the induction of side effects is acommon consequence affecting psychosocial and physiological outcomes. This quasi-experimental study compared physical fitness in recent-term (14–30 months; n= 11) and later-term (74–92 months; n= 8) BCD patients. After inclusion, recent-term BCD patients were engaged in asupervised exercise program and was explored its impact on physical fitness, health-related quality of life (HR-QOL) and fatigue. At baseline (M1) and after 8 (M2) and 16 weeks (M3) of this period, HR-QOL and fatigue were evaluated by the EORTC QLQ-C30 questionnaire and physical fitness through the estimation of maximum oxygen consumption (VO2max,ml.kg.min–1), handgrip force (kg) and sit-stand test. At baseline, women with later-term BCD have revealed better VO2max (p < 0.05) than recent-term BCD patients. There was asignificant time*group interaction for physical fitness outcomes and only the patients who have participated in the exercise program reported significant changes between baseline and at 16 weeks. The observed results demonstrated that performing regular exercise is associated with effective psychosocial and physiological recovery after BCD.

A prática regular de atividade física influencia a saúde e o bem-estar, com papel importante na prevenção de várias doenças crônicas, como doenças cardiovasculares, acidente vascular cerebral, hipertensão, obesidade, diabetes, osteoporose, dentre outras. As vantagens da prática de exercício físico por pessoas com deficiências de desenvolvimento, especificamente de pessoas com transtorno do espetro do autismo (TEA), têm sido estudadas, mas dados as diferentes metodologias e abordagens presentes na literatura, há necessidade de fazer uma compilação das diferentes investigações existentes que permitam concluir quais os efeitos de diferentes tipos de exercício em pessoas com TEA. O objetivo deste artigo é reunir os principais estudos que foram realizados nos últimos anos no âmbito da atividade física em indivíduos com (TEA) e retirar as conclusões acerca dos mesmos. São apresentados 18 estudos, num total de 140 crianças e adultos com várias variantes desta síndrome e que participaram em atividades individualmente ou em grupo. Foram realizadas diversas atividades tais como jogos, natação, corrida, passeios terapêuticos, hidroginástica. As intervenções pretenderam estudar a influência das atividades propostas no comportamento agressivo e estereotipado, funcionamento social, resistência, qualidade de vida e stress, aptidão física e resistência. Os programas de intervenção revelaram melhorias significativas, mostrando as potencialidades do exercício em pessoas com TEA.

Military personnel need physical fitness to effectively carry out operational military activities within their specific field of operation. This research investigates the effects of a 34-week training program on Angolan cadets’ body composition, muscle strength, and cardiorespiratory fitness. Seventy-four volunteer recruits, aged 18 to 26 years, were monitored during their eight-month military service, following an exercise program protocol comprising 12 weeks of strength training followed by 24 weeks of endurance training. Anthropometric variables, including body mass, body mass index, and fat mass, were assessed, along with cardiorespiratory fitness (VO₂max), sprint performance, countermovement jump (CMJ), medicine ball throw, push-ups, and curl-ups. The physical training protocol encompassed running sessions, strength exercises, agility drills, and flexibility exercises. The initial assessment revealed gender differences in various parameters such as body mass, body fat percentage, VO₂max, sprinting, countermovement jump (CMJ), medicine ball throw, and push-ups. Following the training program, changes were observed in all variables (effect size between 0.48 and 2.33, p < 0.01) for the participants. Significant interactions (sex × time) were found in body mass (F = 5.18, p = 0.03, ηp² = 0.06), body fat percentage (F = 5.31, p < 0.01, ηp² = 0.14), and medicine ball throw (F = 10.84, p < 0.01, ηp² = 0.13). Specifically, males exhibited a greater reduction in body mass (females: 2.70%, males: 3.47%, p < 0.05) and a substantial improvement in ball throwing performance (females: 7.74%, males: 11.47%, p < 0.01), while females experienced a greater reduction in fat mass (females: 5.34%, males: 3.15%, p < 0.01). The physical training regimen effectively influenced body composition, particularly in enhancing strength performance among males. The integration of exercise programs with military service led to a notable reduction in fat tissue and an increase in lean tissue. Hence, the development of tailored training protocols is imperative to enhance the physical capacity and overall health of military recruits, considering sex-specific characteristics and physical attributes.

RESUMO: crianças com transtorno do espectro do autismo (TEA) apresentam um desempenho motor inferior às crianças em geral. Com este estudo pretende-se avaliar a eficácia de um programa de treino de trampolins, com a duração de 20 semanas, na proficiência motora e índice de massa corporal (IMC) de crianças com TEA. Participaram um total de 17 crianças (entre os 4 e os 10 anos de idade) com diagnóstico de TEA, que foram distribuídas por dois grupos: grupo experimental (n=6), e controlo (n=11). O grupo experimental foi submetido a uma sessão de treino de trampolins por semana com uma duração de 45 minutos. O grupo de controlo compreende crianças cuja atividade física foi limitada ao currículo obrigatório. A proficiência motora foi avaliada através da bateria de testes Bruininks - Oseretsky. O IMC foi calculado recorrendo à fórmula internacionalmente referenciada. Para análise de variância de medidas repetidas (ANOVA). Ambos os grupos apresentaram características idênticas na avaliação inicial. No que se refere à proficiência motora foram evidentes e significativas as melhorias no GE após o programa de trampolins de 20 semanas (p0.05). Relativamente ao IMC não se registraram alterações significativas em ambos os grupos com a realização do programa de trampolins (p>0.05). Em face deste quadro de resultados é possível concluir que a participação em um programa de trampolins com a duração de 20 semanas contribuiu para melhorar significativamente a proficiência motora de crianças com TEA