The quality of life (QOL) of patients with celiac disease (CD) can be altered by both symptoms of the disease and by the restrictions of the gluten-free diet (GFD). The objective was to determine the factors associated with better QOL in a large cohort of CD patients. A link to an online survey was sent to the members of the French Association of Gluten Intolerant People (AFDIAG). The French-Celiac Disease Questionnaire (F-CDQ), scoring from 0 to 100, was used to measure the QOL. Other data collected were sociodemographic characteristics, information on CD, purchasing and consumption habits of gluten-free products, and a self-assessment scale (ranging from 0 to 10) to determine the compliance with the GFD. Among the 907 CD patients who returned the questionnaire, 787 were analyzed (638 women (81%); median age: 49 years; 71% with self-assessed GFD compliance > 8). Their median F-CDQ was 73 (range: 59–82). In multivariate analysis, the main factors associated with a better quality of life were the long duration of the GFD, good compliance with the GFD, and the number of follow-up visits. Compliance with and duration of the GFD are associated with a better quality of life in patients with CD. Taking this into consideration would offset its restrictive aspect and improve its adherence.

Advanced glycation end-products (AGE) are the product of non-enzymatic reactions between reduced carbohydrates, peptides, lipids, nucleic acids. AGE accumulate over time, they are considered as the metabolic memory. In certain pathologies such as diabetes mellitus, AGE accumulation is increased and correlated with vascular complications. Patients with chronic intestinal failure dependent on parenteral nutritional have long-term intravenous carbohydrate intakes. The assessment of AGE levels in this population has never been performed. We measured skin AGE levels by auto-fluorescence in 23 adults followed in a tertiary center for chronic intestinal insufficiency and treated with home parenteral nutrition that we compared to the values of the general population. We also analyzed factors associated with elevated AGE. More than half (n=13) had elevated AGE. The presence of elevated AGE was significantly associated with higher parenteral carbohydrate intakes. Patients with elevated AGE had higher intravenous carbohydrate intakes (median 3.3g/kg/day [1.84;3.62]), compared to patients with normal AGE (1.79g/kg/d [1.45;2.26], p=0.03). The presence of chronic renal failure was also associated with elevated AGE. This preliminary study suggests that AGE accumulation is increased in subjects on prolonged parenteral nutrition. Studies with larger numbers will be necessary to confirm this hypothesis and to evaluate the association with cardiovascular events.