In this paper, the importance of isospin symmetry and its breaking in elucidating the properties of atomic nuclei is reviewed. The quark mass splitting and the electromagnetic origin of the isospin symmetry breaking (ISB) for the nuclear many-body problem is discussed. The experimental data on isobaric analogue states cannot be described only with the Coulomb interaction, and ISB terms in the nucleon–nucleon interaction are needed to discern the observed properties. In the present work, the ISB terms are explicitly considered in nuclear energy density functional and spherical shell model approaches, and a detailed investigation of the analogue states and other properties of nuclei is performed. It is observed that isospin mixing is largest for the N = Z system in the density functional approach