Improvements in physical and adaptive psychosocial challenges after Coronary artery bypass grafting (CABG) is unclear to what extent these outcomes impact patients' health-related quality of life. This study was to determine the quality of life among patients 3 months after CABG surgery. More specifically, the study examines the contribution of a set of variables on the quality of life. A prospective cohort study was performed over 3 months among 219 adult patients prepared for elective Coronary Artery Bypass Grafting. The data on the baseline measurements Short Form-36 to measure self-reported health-related quality of life and the state-trait anxiety inventory scale to assess anxiety were collected two days before and three months after CABG surgery. The Pearson correlation coefficient was adopted to examine the relationship between confounding, predictor, and dependent variables. Shapiro-Wilk test tested the normality of the distribution of numerical variables. A 2-tailed level of P-value < 0.05 was set to be statistically significant for all analyses. Mean preoperative postoperative physical and mental component score was 34.57 ± 9.6, 43.53 ± 7 and 54.87 ± 1.19, 51.65 ± 9.67, respectively, indicating poor quality of life. Preoperative anxiety uniquely explained with the variation 32.1% and 29.9% and it significantly predicts postoperative physical health quality of life as (β = .535, t = 8.433, P < 0.001) and postoperative mental health quality of life as (β = .475, t = 7.147, P < 0.001) respectively. Significant improvement in physical health over the 3 months was confirmed, but mental health-related quality of life is unconvincing with the substantial contribution of anxiety.

Background: Although radiotherapy is one of the main cancer treatment modalities, exposing healthy organs/tissues to ionizing radiation during treatment can lead to different adverse effects. In this regard, it has been shown that the use of radioprotective agents may alleviate the ionizing radiation-induced toxicities. Objective: The present study aims to review the radioprotective potentials of silymarin/silibinin in the prevention/reduction of ionizing radiation-induced adverse effects on healthy cells/tissues. Methods: Based on PRISMA guidelines, a comprehensive and systematic search was performed for identifying relevant literature on the “potential protective role of silymarin/silibinin in the treatment of radiotherapy-induced toxicities” in the different electronic databases of Web of Science, PubMed, and Scopus up to April 2022. Four hundred and fifty-five articles were obtained and screened in accordance with the inclusion and exclusion criteria of the current study. Finally, 19 papers were included in this systematic review. Results: The findings revealed that the ionizing radiation-treated groups had reduced survival rates and body weight in comparison with the control groups. It was also found that radiation can induce mild to severe adverse effects on the skin, digestive, hematologic, lymphatic, respiratory, reproductive, and urinary systems. Nevertheless, the administration of silymarin/silibinin could mitigate the ionizing radiation-induced adverse effects in most cases. This herbal agent exerts its radioprotective effects through anti-oxidant, anti-apoptosis, anti-inflammatory activities, and other mechanisms. Conclusion: The results of the current systematic review showed that co-treatment of silymarin/silibinin with radiotherapy alleviates the radiotherapy-induced adverse effects in healthy cells/tissues.

Background: World health organization announced COVID-19 as a pandemic crisis in march 2020. As of WHO statistics 2020 September, the incidence appears to be accelerating globally, with the soaring of new cases since the last one week. Even though worldwide incidence and further deaths have decreased in recent weeks across a few nations, the panic situation has caused unprecedented stress among frontline healthcare workers. Nurses fall into the category of full-blown anxiety responses syndrome to undergo burnout post-traumatic stress disorder. Purpose: This research aimed to explore the perceptions of frontline healthcare workers (Nurses)’ and their opinion about healthcare resources while caring for COVID-19 patients. Methodology: The study adopted a mixed-method where the quantitative data collected using a google document questionnaire related to healthcare resources followed by a qualitative method of online individual interview method to explore the in-depth analysis of nurses’ perceptions of caring for coronaviruses infected patients. Results: The results revealed the nurses’ concerns about the everyday routine of delivering care to COVID-19 patients, including a moderate level of resilience in healthcare resources authorities. The barriers faced by nurses in the journey of a pandemic crisis were also discussed in this study that could also render substantial support in establishing policies and guidelines to meet the needed population’s healthcare needs. Conclusions: Health care workers, including nurses, tend to experience work-related stress that could be alleviated by the appropriate staffing, equipment and supplies, training programs, and staff welfare programs.