Background/Objectives: Psychological distress, including anxiety and depression, significantly impacts quality of life (QoL) in colorectal cancer patients. This study explores the relationship between psychological distress and QoL, identifies risk factors (e.g., advanced disease stage, socioeconomic status, and social support levels), and evaluates the influence of emotional and social functioning on patient well-being. Additionally, this study examines workplace reintegration challenges faced by cancer survivors. Methods: A longitudinal study was conducted with 50 patients diagnosed with colorectal cancer undergoing chemotherapy. QoL was assessed using the EORTC QLQ-C30 and EQ-5D scales, while anxiety and depression were measured using the Hospital Anxiety and De-pression Scale (HADS). Assessments were conducted at baseline and at the end of a six-month treatment period. Data were analyzed using correlation and multivariate regression analyses to explore associations between psychological distress and QoL, adjusting for disease stage, social support, and demographic factors. Results: Emotional functioning showed a statistically significant improvement by the sixth chemotherapy cycle (p < 0.05), while physical and role functions remained stable. However, psychological health, as assessed through HADS, showed no significant improvement, highlighting the need for targeted psychological support. Negative correlations were observed between QoL scores and anxiety and depression levels, with stronger associations detected in the later stages of treatment. Patients with advanced disease stages and poor social support were identified as high-risk groups for psychological distress. Effect sizes (Cohen’s d) and confidence intervals were calculated to assess the practical significance of findings. Conclusions: This study highlights the critical impact of psychological distress on the QoL of colorectal cancer patients, emphasizing the importance of integrating systematic psychological assessments and tailored interventions in oncology care. Future research should incorporate larger sample sizes, extended follow-up periods, and an exploration of mediating factors to enhance understanding and improve patient-centered interventions.

Gastrointestinal problems are among the most common health problems which can acutely affect the healthy population and chronically involve health risks, seriously affecting the quality of life. Identifying the risk of gastrointestinal diseases in the early phase by indirect methods can increase the healing rate and the quality of life.: The proposal of this study is to verify a correlation between gastrointestinal and periodontal problems and the risk of inflammatory gastrointestinal diseases (IBD). The study was conducted on 123 people who were observed to have gastrointestinal and psychological problems. The participants were divided into three groups, depending on each one’s diagnosis. The control group (CG) was composed of 37 people who did not fit either irritable bowel syndrome (IBS) according to the ROME IV criteria, nor were inflammatory markers positive for IBD. Group 2 (IBS) was composed of 44 participants diagnosed with IBS according to the ROME IV criteria. Group 3 was composed of 42 participants who were diagnosed with IBD. All study participants underwent anthropometric, micro-Ident, and quality of life tests. A directly proportional relationship of the presence of bacteria with IBD patients with the exception of Capnocytophaga spp. and Actinobacillus actinomycetemcomitans was observed. These two bacteria correlated significantly with IBS. Follow-up of the study participants will help determine whether periodontal disease can be used as an indicator of severe colorectal disease. In addition, this study should be continued especially in the case of IBD more thoroughly to follow and reduce the risk of malignancy.

Cognitive behavioral therapy (CBT) has proven effective in addressing the psychological and emotional challenges of cancer. This study evaluated the impact of a self-esteem enhancement intervention integrated into a standard CBT protocol on the quality of life and self-esteem of women with colorectal cancer. Conducted at Spitalul Județean Clinic Bihor (Romania) between August 2020 and March 2024, the study included 67 women aged 32 to 66 years undergoing chemotherapy or combined chemotherapy and radiotherapy. This study aimed to evaluate the impact of a self-esteem enhancement intervention integrated into a standard CBT protocol on the quality of life and self-esteem of women with colorectal cancer. Participants were assigned to a CBT group, receiving eight weekly sessions based on the Simonton Program, or a control group on a psychotherapy waiting list. Quality of life was assessed using the EORTC QLQ-C30 questionnaire, and self-esteem was measured through actual and ideal self-perceptions. A repeated measures ANOVA analyzed changes in both outcomes. Results showed a significant improvement in quality of life (F = 6.33, df = 1, 65, p < 0.05) and self-esteem (F = 4.46, df = 1, 65, p < 0.05) in the CBT group, whereas no improvements were observed in the control group. Self-esteem was enhanced through reduced discrepancies between actual and ideal self-perceptions, especially in cognitive and emotional dimensions. Physical functioning improved but was less pronounced, influenced by disease progression and treatment stage. No significant changes were observed in social functioning, suggesting that longer-term interventions may be needed. These findings highlight CBT as a valuable complementary intervention in oncology care, supporting its integration into standard treatment to enhance patients’ psychological well-being and quality of life.

Background and objectives: Irritable bowel syndrome (IBS) does not only have a complex pathophysiological evolution with central and peripheral mechanisms. This study aimed to monitor the neuropsychiatric part of IBS and its management, following the quality of life of patients with IBS. Materials and Methods: Participants numbering 145 were investigated in this study for 6 months and were divided into four groups, namely the control group with a symptomatic period of less than 6 months (n = 34), the group with irritable bowel syndrome (IBS; n = 58), IBS and neuropsychiatric treatment (n = 32), and IBS with probiotic treatment (n = 22). Clinical and paraclinical analyses as well as quality of life were monitored by domestic and international psychological questionnaires. Results: It was observed that, in patients with pro-longed symptoms, neuropsychiatric impairment occurred more frequently, and both clinical and paraclinical analyses improved significantly (p < 0.05) more so in those with complex allopathic treatment and in those with probiotic treatment. There were no significant differences between the two research groups. Conclusions: It has been shown that the neuropsychological component of IBS plays an important role in its treatment, and modern probation therapy can achieve similar results to those of neuropsychiatry. This also requires further studies to ensure the best combination in the approach to IBS.