The accuracy of saccadic eye movements is maintained over the long term by adaptation mechanisms that decrease or increase saccade amplitude. It is still unknown whether these opposite adaptive changes rely on common mechanisms. Here, a double-step target paradigm was used to adaptively decrease (backward second target step) or increase (forward step) the amplitude of reactive saccades in one direction only. To test which sensorimotor transformation stages are subjected to these adaptive changes, we measured their transfer to antisaccades in which sensory and motor vectors are spatially dissociated. In the backward adaptation condition, all subjects showed a significant amplitude decrease for adapted prosaccades and a significant transfer of adaptation to antisaccades performed in the adapted direction, but not to oppositely directed antisaccades elicited by a target jump in the adapted direction. In the forward adaptation condition, only 14 of 19 subjects showed a significant amplitude increase for prosaccades and no significant adaptation transfer to antisaccades was detected in either the adapted or nonadapted direction. These findings suggest that, whereas the level(s) of forward adaptation cannot be resolved, the mechanisms involved in backward adaptation of reactive saccades take place at a sensorimotor level downstream from the vector inversion process of antisaccades and differ markedly from those involved in forward adaptation.

Sensorimotor adaptation ensures movement accuracy despite continuously changing environment and body. Adaptation of saccadic eye movements is a classical model of sensorimotor adaptation. Beside the well-established role of the brainstem–cerebellum in the adaptation of reactive saccades (RSs), the cerebral cortex has been suggested to be involved in the adaptation of voluntary saccades (VSs). Here, we provide direct evidence for a causal involvement of the parietal cortex in saccadic adaptation. First, the posterior intraparietal sulcus (pIPS) was identified in each subject using functional magnetic resonance imaging (fMRI). Then, a saccadic adaptation paradigm was used to progressively reduce the amplitude of RSs and VSs, while single-pulse transcranial magnetic stimulation (spTMS) was applied over the right pIPS. The perturbations of pIPS resulted in impairment for the adaptation of VSs, selectively when spTMS was applied 60 ms after saccade onset. In contrast, the adaptation of RSs was facilitated by spTMS applied 90 ms after saccade initiation. The differential effect of spTMS relative to saccade types suggests a direct interference with pIPS activity for the VS adaptation and a remote interference with brainstem–cerebellum activity for the RS adaptation. These results support the hypothesis that the adaptation of VSs and RSs involves different neuronal substrates.

"Social facilitation" refers to the enhancement or impairment of performance engendered by the mere presence of others. It has been demonstrated for a diversity of behaviors. This study assessed whether it also concerns attention and eye movements, and if yes, which decision making mechanisms it affects. Human volunteers were tested in three different tasks (saccades, visual search and continuous performance) either alone or in the presence of a familiar peer. The results failed to reveal any significant peer influence on the visual search and continuous performance tasks. For saccades, by contrast, they showed a negative or positive peer influence depending on the complexity of the testing protocol. Pro-and anti-saccades were both inhibited when pseudorandomly mixed, and both facilitated when performed separately. Peer presence impaired or improved reaction times, i.e the speed to initiate the saccade, as well as peak velocity, i.e. the driving force moving the eye toward the target. Effect sizes were large, with Cohen's d values ranging for RTs from 0.50 to 0.95. Analyzing RT distributions using the LATER model revealed that social inhibition of pro- and anti-saccades in the complex protocol was associated with a significant increase of the rate of rise. The present demonstration that the simple presence of a familiar peer can inhibit or facilitate saccades depending on task difficulty strengthens a growing body of evidence showing social modulations of eye movements and attention processes. The present lack of effect on visual search and continuous performance tasks contrasts with peer presence effects reported earlier using similar tasks, and future studies are needed to determine whether it is due to an intermediate level of difficulty maximizing individual variability. Together with an earlier study of the social inhibition of anti-saccades also using the LATER model, which showed an increase of the threshold, the present increase of the rate of rise suggests that peer presence can influence both the top-down and bottom-up attention-related processes guiding the decision to move the eyes.

The brainstem and cerebellum contain many neuronal types that play a critical role in eye movement control. In a physiological approach, understanding how these neuronal assemblies cooperate provides strong insight into general brain functions. Furthermore, eye movements provide an interesting model for understanding neural mechanisms of sensorimotor learning, and a knowledge of the mechanisms underlying oculomotor plasticity is essential for correctly diagnosing and effectively managing patients. Finally, knowledge of the ocular motor syndromes frequently helps localize the pathological abnormality. We review the recently published works dealing with the physiological organization and pathology of slow and rapid eye movements at a brainstem and cerebellar level. The main recent findings of great interest for clinical practice or research concern the physiopathology of head shaking nystagmus, downbeat nystagmus and oculopalatal tremor; the neural substrates of three-dimensional control of eye movements and of optokinetic nystagmus; the understanding of saccade generation and of its consequences on physiological and pathological eye oscillations; and, finally, the physiological basis of saccadic adaptation.

Vertebrates developed sophisticated solutions to select environmental visual information, being capable of moving attention without moving the eyes. A large body of behavioural and neuroimaging studies indicate a tight coupling between eye movements and spatial attention. The nature of this link, however, remains highly debated. Here we demonstrate that deployment of human covert attention, measured in stationary eye conditions, can be boosted across space by changing the size of ocular saccades to a single position via a specific adaptation paradigm. These findings indicate that spatial attention is more widely affected by oculomotor plasticity than previously thought.