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Eight extraction technologies were used to extract sweet tea (Lithocarpus litseifolius (Hance) Chun) crude polysaccharides (STPs), and their chemical, structural, and biological properties were studied and compared. Results revealed that the compositions, structures, and biological properties of STPs varied dependent on different extraction technologies. Protein-bound polysaccharides and some hemicellulose could be extracted from sweet tea with diluted alkali solution. STPs extracted by deep-eutectic solvents and diluted alkali solution exhibited the most favorable biological properties. Moreover, according to the heat map, total phenolic content was most strongly correlated with biological properties, indicating that the presence of phenolic compounds in STPs might be the main contributor to their biological properties. To the best of our knowledge, this study reports the chemical, structural, and biological properties of STPs, and the results contribute to understanding the relationship between the chemical composition and biological properties of STPs.
Huan Guo; Meng-Xi Fu; Yun-Xuan Zhao; Hang Li; Hua-Bin Li; Ding-Tao Wu; Ren-You Gan. The Chemical, Structural, and Biological Properties of Crude Polysaccharides from Sweet Tea (Lithocarpus litseifolius (Hance) Chun) Based on Different Extraction Technologies. Foods 2021, 10, 1779 .
AMA StyleHuan Guo, Meng-Xi Fu, Yun-Xuan Zhao, Hang Li, Hua-Bin Li, Ding-Tao Wu, Ren-You Gan. The Chemical, Structural, and Biological Properties of Crude Polysaccharides from Sweet Tea (Lithocarpus litseifolius (Hance) Chun) Based on Different Extraction Technologies. Foods. 2021; 10 (8):1779.
Chicago/Turabian StyleHuan Guo; Meng-Xi Fu; Yun-Xuan Zhao; Hang Li; Hua-Bin Li; Ding-Tao Wu; Ren-You Gan. 2021. "The Chemical, Structural, and Biological Properties of Crude Polysaccharides from Sweet Tea (Lithocarpus litseifolius (Hance) Chun) Based on Different Extraction Technologies." Foods 10, no. 8: 1779.
The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.
Dan-Dan Zhou; Min Luo; Si-Yu Huang; Adila Saimaiti; Ao Shang; Ren-You Gan; Hua-Bin Li. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -15.
AMA StyleDan-Dan Zhou, Min Luo, Si-Yu Huang, Adila Saimaiti, Ao Shang, Ren-You Gan, Hua-Bin Li. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-15.
Chicago/Turabian StyleDan-Dan Zhou; Min Luo; Si-Yu Huang; Adila Saimaiti; Ao Shang; Ren-You Gan; Hua-Bin Li. 2021. "Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases." Oxidative Medicine and Cellular Longevity 2021, no. : 1-15.
Nonalcoholic fatty liver diseases (NAFLD) represent a set of liver disorders progressing from steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, which induce huge burden to human health. Many pathophysiological factors are considered to influence NAFLD in a parallel pattern, involving insulin resistance, oxidative stress, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammatory cascades, fibrogenic reaction, etc. However, the underlying mechanisms, including those that induce NAFLD development, have not been fully understood. Specifically, oxidative stress, mainly mediated by excessive accumulation of reactive oxygen species, has participated in the multiple NAFLD-related signaling by serving as an accelerator. Ameliorating oxidative stress and maintaining redox homeostasis may be a promising approach for the management of NAFLD. Green tea is one of the most important dietary resources of natural antioxidants, above which epigallocatechin gallate (EGCG) notably contributes to its antioxidative action. Accumulative evidence from randomized clinical trials, systematic reviews, and meta-analysis has revealed the beneficial functions of green tea and EGCG in preventing and managing NAFLD, with acceptable safety in the patients. Abundant animal and cellular studies have demonstrated that green tea and EGCG may protect against NAFLD initiation and development by alleviating oxidative stress and the related metabolism dysfunction, inflammation, fibrosis, and tumorigenesis. The targeted signaling pathways may include, but are not limited to, NRF2, AMPK, SIRT1, NF-κB, TLR4/MYD88, TGF-β/SMAD, and PI3K/Akt/FoxO1, etc. In this review, we thoroughly discuss the oxidative stress-related mechanisms involved in NAFLD development, as well as summarize the protective effects and underlying mechanisms of green tea and EGCG against NAFLD.
GuoYi Tang; Yu Xu; Cheng Zhang; Ning Wang; Huabin Li; Yibin Feng. Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism. Antioxidants 2021, 10, 1076 .
AMA StyleGuoYi Tang, Yu Xu, Cheng Zhang, Ning Wang, Huabin Li, Yibin Feng. Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism. Antioxidants. 2021; 10 (7):1076.
Chicago/Turabian StyleGuoYi Tang; Yu Xu; Cheng Zhang; Ning Wang; Huabin Li; Yibin Feng. 2021. "Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism." Antioxidants 10, no. 7: 1076.
Akebia trifoliata is a fruit with rich nutritional properties, and its peel is produced as a by-product. In this research, we investigated the influences of microwave-assisted extraction parameters on antioxidant activity of the extract from Akebia trifoliata peels, and the ferric-reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) as well as total phenolic contents (TPC) were used to optimize extraction parameters. The influences of ethanol concentration, microwave power and solvent-to-material ratio, as well as extraction temperature and time on TPC, FRAP and TEAC values, were assessed using single-factor tests. Three parameters with obvious effects on antioxidant capacity were selected to further investigate their interactions by response surface methodology. The optimal extraction parameters of natural antioxidants from Akebia trifoliata peels were ethanol concentration, 49.61% (v/v); solvent-to-material ratio, 32.59:1 mL/g; extraction time, 39.31 min; microwave power, 500 W; and extraction temperature, 50 °C. Under optimal conditions, the FRAP, TEAC and TPC values of Akebia trifoliata peel extracts were 351.86 ± 9.47 µM Fe(II)/g dry weight (DW), 191.12 ± 3.53 µM Trolox/g DW and 32.67 ± 0.90 mg gallic acid equivalent (GAE)/g DW, respectively. Furthermore, the main bioactive compounds (chlorogenic acid, rutin and ellagic acid) in the extract were determined by high-performance liquid chromatography. The results are useful for the full utilization of the by-product from Akebia trifoliate fruit.
Min Luo; Dan-Dan Zhou; Ao Shang; Ren-You Gan; Hua-Bin Li. Influences of Microwave-Assisted Extraction Parameters on Antioxidant Activity of the Extract from Akebia trifoliata Peels. Foods 2021, 10, 1432 .
AMA StyleMin Luo, Dan-Dan Zhou, Ao Shang, Ren-You Gan, Hua-Bin Li. Influences of Microwave-Assisted Extraction Parameters on Antioxidant Activity of the Extract from Akebia trifoliata Peels. Foods. 2021; 10 (6):1432.
Chicago/Turabian StyleMin Luo; Dan-Dan Zhou; Ao Shang; Ren-You Gan; Hua-Bin Li. 2021. "Influences of Microwave-Assisted Extraction Parameters on Antioxidant Activity of the Extract from Akebia trifoliata Peels." Foods 10, no. 6: 1432.
Tea is one of the three most widely consumed beverages in the world, not only because of its unique flavor but also due to its various health benefits. The bioactive components in tea, such as polyphenols, polysaccharides, polypeptides, pigments, and alkaloids, are the main contributors to its health functions. Based on epidemiological surveys, the consumption of tea and its compounds in daily life has positive effects on cardiovascular diseases, cancers, hepatopathy, obesity, and diabetes mellitus. In experimental studies, the antioxidant, anti-inflammatory, anti-cancer, anti-obesity, cardiovascular protective, liver protective, and hypoglycemic activities of tea and the related mechanisms of action have been widely investigated. The regulation of several classical signaling pathways, such as nuclear factor-κB (NF-κB), AMP activated protein kinase (AMPK), and wingless/integrated (Wnt) signaling, is involved. Clinical trials have also demonstrated the potential of tea products to be applied as dietary supplements and natural medicines. In this paper, we reviewed and discussed the recent literature on the health benefits of tea and its compounds, and specifically explored the molecular mechanisms involved.
Ao Shang; Jia-Hui Li; Dan-Dan Zhou; Ren-You Gan; Hua-Bin Li. Molecular mechanisms underlying health benefits of tea compounds. Free Radical Biology and Medicine 2021, 172, 181 -200.
AMA StyleAo Shang, Jia-Hui Li, Dan-Dan Zhou, Ren-You Gan, Hua-Bin Li. Molecular mechanisms underlying health benefits of tea compounds. Free Radical Biology and Medicine. 2021; 172 ():181-200.
Chicago/Turabian StyleAo Shang; Jia-Hui Li; Dan-Dan Zhou; Ren-You Gan; Hua-Bin Li. 2021. "Molecular mechanisms underlying health benefits of tea compounds." Free Radical Biology and Medicine 172, no. : 181-200.
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several advantageous features have facilitated zebrafish to be extensively utilized as a valuable vertebrate model in the lab. It has been well-recognized that natural products possess multiple health benefits for humans. With the increasing demand for natural products in the development of functional foods, nutraceuticals, and natural cosmetics, the zebrafish has emerged as an unprecedented tool for rapidly and economically screening and identifying safe and effective substances from natural products. This review first summarized the key factors for the management of zebrafish in the laboratory, followed by highlighting the current progress on the establishment and applications of zebrafish models in the bioactivity evaluation of natural products. In addition, the zebrafish models used for assessing the potential toxicity or health risks of natural products were involved as well. Overall, this review indicates that zebrafish are promising animal models for the bioactivity and safety evaluation of natural products, and zebrafish models can accelerate the discovery of novel natural products with potential health functions.
Fang-Jun Lin; Hang Li; Ding-Tao Wu; Qi-Guo Zhuang; Hua-Bin Li; Fang Geng; Ren-You Gan. Recent development in zebrafish model for bioactivity and safety evaluation of natural products. Critical Reviews in Food Science and Nutrition 2021, 1 -29.
AMA StyleFang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng, Ren-You Gan. Recent development in zebrafish model for bioactivity and safety evaluation of natural products. Critical Reviews in Food Science and Nutrition. 2021; ():1-29.
Chicago/Turabian StyleFang-Jun Lin; Hang Li; Ding-Tao Wu; Qi-Guo Zhuang; Hua-Bin Li; Fang Geng; Ren-You Gan. 2021. "Recent development in zebrafish model for bioactivity and safety evaluation of natural products." Critical Reviews in Food Science and Nutrition , no. : 1-29.
Gut microbiota dysbiosis has been a crucial contributor to the pathogenesis of alcoholic fatty liver disease (AFLD). Tea is a popular beverage worldwide and exerts antioxidant and anti-inflammatory activities, as well as hepatoprotective effects. However, the potential role of gut microbiota regulated by tea in the prevention and management of AFLD remains unclear. Here, the protective effects of oolong tea, black tea, and dark tea on AFLD and its regulation of gut microbiota in chronic alcohol-exposed mice were explored and investigated. The results revealed that tea supplementation significantly prevented liver steatosis, decreased oxidative stress and inflammation, and modulated gut microbiota in chronic alcohol-exposed mice, especially oolong tea and dark tea. However, black tea showed less effectiveness against liver injury caused by alcohol. Moreover, the diversity, structure and composition of chronic alcohol-disrupted gut microbiota were restored by the supplementation of oolong tea and dark tea based on the analysis of gut microbiota. Furthermore, the relationship between liver injury biochemical indicators and gut microbiota indicated that some specific bacteria, such as Bacteroides, Alloprevotella, and Parabacteroides were closely associated with AFLD. In addition, the phytochemical components in tea extracts were measured by high-performance liquid chromatography, which could contribute to preventive effects on AFLD. In summary, oolong tea and dark tea could prevent chronic alcohol exposure-induced AFLD by modulating gut microbiota.
Bangyan Li; Qianqian Mao; Dandan Zhou; Min Luo; Renyou Gan; Hangyu Li; Siyu Huang; Adila Saimaiti; Ao Shang; Huabin Li. Effects of Tea against Alcoholic Fatty Liver Disease by Modulating Gut Microbiota in Chronic Alcohol-Exposed Mice. Foods 2021, 10, 1232 .
AMA StyleBangyan Li, Qianqian Mao, Dandan Zhou, Min Luo, Renyou Gan, Hangyu Li, Siyu Huang, Adila Saimaiti, Ao Shang, Huabin Li. Effects of Tea against Alcoholic Fatty Liver Disease by Modulating Gut Microbiota in Chronic Alcohol-Exposed Mice. Foods. 2021; 10 (6):1232.
Chicago/Turabian StyleBangyan Li; Qianqian Mao; Dandan Zhou; Min Luo; Renyou Gan; Hangyu Li; Siyu Huang; Adila Saimaiti; Ao Shang; Huabin Li. 2021. "Effects of Tea against Alcoholic Fatty Liver Disease by Modulating Gut Microbiota in Chronic Alcohol-Exposed Mice." Foods 10, no. 6: 1232.
Many harmful substances have been found in foods, such as heavy metals, organic pollutants, pesticides and antibiotics, and food additives are widely used in the industry. Recent studies showed that these substances could affect the composition and diversity of gut microbiota, which plays important roles in health and diseases of host. Thus, these substances could show toxicities through disrupting the homeostasis of gut microbiota. On the other hand, some dietary bioactive compounds were found to restore the dysbiosis of gut microbiota. Therefore, certain dietary natural products could relieve the toxicities of harmful substances on human beings via regulating gut microbiota. In this review, the influences of several harmful substances and additives on gut microbiota are summarized, and protective effects of dietary bioactive compounds are also discussed. It is hoped to provide a better understanding of dietary natural products to reduce toxicities of harmful substances on human beings by targeting gut microbiota. Considering wide existence of harmful substances and additives in foods, this topic would attract more attention in the future to protect human health. Gut microbiota plays a vital role in diseases and health based on human and most animal studies. Some gut microbes, such as Bifidobacterium and Lactobacillus, could synthesize various essential nutrients for human growth. In addition, some Bifidobacterium strains, Clostridium tyrobutyricum, and Lactobacillus paracasei, were associated with anti-inflammatory property. Moreover, Anaerostipes, Corynebacterium, Dorea, Roseburia, Ruminococcus, and Turicibacter, were also related to inflammation. Harmful substances, such as atrazine, polychlorinated biphenyl, and heavy metals, were mainly ingested through the contaminated water and foods, could disturb gut microbiota and be detrimental to health. Besides, gut microbiota dysbiosis was potentially caused by some food additives, which altered gut barrier and activated the immune response. On the other hand, some dietary natural products, such as melatonin, wheat bran, pectin, chlorogenic acid, and isoorientin, showed beneficial efficacy through restoring dysbiosis of gut microbiota caused by harmful substances. In the future, more attention should be paid to the exploration of more dietary plants and their components with gut microbiota regulatory effects in order to reduce the toxicities of harmful substances and protect human health.
Min Luo; Dan-Dan Zhou; Ao Shang; Ren-You Gan; Hua-Bin Li. Influences of food contaminants and additives on gut microbiota as well as protective effects of dietary bioactive compounds. Trends in Food Science & Technology 2021, 1 .
AMA StyleMin Luo, Dan-Dan Zhou, Ao Shang, Ren-You Gan, Hua-Bin Li. Influences of food contaminants and additives on gut microbiota as well as protective effects of dietary bioactive compounds. Trends in Food Science & Technology. 2021; ():1.
Chicago/Turabian StyleMin Luo; Dan-Dan Zhou; Ao Shang; Ren-You Gan; Hua-Bin Li. 2021. "Influences of food contaminants and additives on gut microbiota as well as protective effects of dietary bioactive compounds." Trends in Food Science & Technology , no. : 1.
Nonalcoholic fatty liver disease (NAFLD) is considered as a severe threat to human health. It has been reported that tea has abundant bioactive compounds and beneficial effects. In our study, the effects of 12 tea extracts on NAFLD were assessed and compared at the dose of 200 mg/kg body weight in mice fed with a high‐fat diet (HFD) for 15 weeks. Enshi Yulu Tea, Fenghuang Narcissus Tea, and Yihong Tea showed strong effects in suppressing the accumulation of epididymal and perirenal adipose tissue as well as the increases of body weight and liver weight. The histopathological analysis revealed that hepatic steatosis and adipocyte hypertrophy induced by a HFD could be ameliorated by tea supplementation. In addition, Enshi Yulu Tea and Qing Brick Tea exerted more remarkable functions on decreasing the level of serum triglyceride and preventing hepatic fat accumulation, respectively. Furthermore, Fenghuang Narcissus Tea, Enshi Yulu Tea, and Qing Brick Tea could reverse the abnormal change in the levels of glutathione and superoxide dismutase. Moreover, 13 phytoconstituents were detected and quantified in these teas with high‐performance liquid chromatography (HPLC) method. The correlation analysis demonstrated that gallic acid might decrease MDA level, and the reduction of liver weight might be attributed to ellagic acid. However, it should be paid attention to some teas that showed hepatotoxicity with elevated levels of aspartate transaminase and alanine aminotransferase. Several teas showed strong effects in the prevention of NAFLD, which could be developed into functional foods against NAFLD.
Qian‐Qian Mao; Bang‐Yan Li; Jin‐Ming Meng; Ren‐You Gan; Xiao‐Yu Xu; Ying‐Ying Gu; Xiao‐Hui Wang; Hua‐Bin Li. Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet. Food Science & Nutrition 2021, 9, 2954 -2967.
AMA StyleQian‐Qian Mao, Bang‐Yan Li, Jin‐Ming Meng, Ren‐You Gan, Xiao‐Yu Xu, Ying‐Ying Gu, Xiao‐Hui Wang, Hua‐Bin Li. Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet. Food Science & Nutrition. 2021; 9 (6):2954-2967.
Chicago/Turabian StyleQian‐Qian Mao; Bang‐Yan Li; Jin‐Ming Meng; Ren‐You Gan; Xiao‐Yu Xu; Ying‐Ying Gu; Xiao‐Hui Wang; Hua‐Bin Li. 2021. "Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high‐fat diet." Food Science & Nutrition 9, no. 6: 2954-2967.
Neurodegenerative and neuropsychiatric diseases have attracted global attention with an overwhelming burden on families and society. Tea contains many bioactive compounds, such as polyphenols and theanine, which could contribute to the neuroprotective effects of tea. The possible mechanisms of action include regulating signaling pathways and gut microbiota; inhibiting abnormal protein aggregation; normalizing the hyperactivity of the hypothalamic-pituitary-adrenal axis; as well as antioxidant and anti-inflammatory properties of tea for Parkinson’s disease, Alzheimer’s disease, and depression. In this narrative revie w, the effects of tea on these diseases were summarized, and special attention was paid to the mechanisms of action. Abbreviations: AChE, acetylcholinesterase; ACTH, adrenocorticotropin; AKT, serine-threonine protein kinase; BChE, butyrylcholinesterase; BDNF, brain-derived neurotrophic factor; CI, confidence interval; COX-2, cyclooxygenase-2; CRH, corticotrophin-releasing hormone; CREB, cyclic adenosine monophosphate response element-binding protein; EC, epicatechin; ECG, epicatechin-3-gallate; EGC, epigallocatechin; EGCG, epigallocatechin gallate; ERK, extracellular signal-regulated kinase; GABA, gamma-aminobutyric acid; GSK-3β, glycogen synthase kinase-3β; HPA, hypothalamic-pituitary-adrenal; HR, hazard ratio; IL, interleukin; MAOB, monoamine oxidase B; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NFκB, nuclear factor kappa-light-chain-enhancer of activated B cells; Nrf2, nuclear factor erythroid 2-related factor 2; NOS, nitric oxide species; OR, odds ratio; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; PI3K, phosphoinositide 3-kinase; PKC, protein kinase C; ROS, reactive oxygen species; RR, risk ratio; TLR4, Toll-like receptor 4; TNF-α; umor necrosis factor alpha; 6-OHDA, 6-hydroxydopamine.
Min Luo; Ren-You Gan; Bang-Yan Li; Qian-Qian Mao; Ao Shang; Xiao-Yu Xu; Hang-Yu Li; Hua-Bin Li. Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression. Food Reviews International 2021, 1 -29.
AMA StyleMin Luo, Ren-You Gan, Bang-Yan Li, Qian-Qian Mao, Ao Shang, Xiao-Yu Xu, Hang-Yu Li, Hua-Bin Li. Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression. Food Reviews International. 2021; ():1-29.
Chicago/Turabian StyleMin Luo; Ren-You Gan; Bang-Yan Li; Qian-Qian Mao; Ao Shang; Xiao-Yu Xu; Hang-Yu Li; Hua-Bin Li. 2021. "Effects and Mechanisms of Tea on Parkinson’s Disease, Alzheimer’s Disease and Depression." Food Reviews International , no. : 1-29.
Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.
Hang-Yu Li; Ren-You Gan; Ao Shang; Qian-Qian Mao; Quan-Cai Sun; Ding-Tao Wu; Fang Geng; Xiao-Qin He; Hua-Bin Li. Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -23.
AMA StyleHang-Yu Li, Ren-You Gan, Ao Shang, Qian-Qian Mao, Quan-Cai Sun, Ding-Tao Wu, Fang Geng, Xiao-Qin He, Hua-Bin Li. Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-23.
Chicago/Turabian StyleHang-Yu Li; Ren-You Gan; Ao Shang; Qian-Qian Mao; Quan-Cai Sun; Ding-Tao Wu; Fang Geng; Xiao-Qin He; Hua-Bin Li. 2021. "Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application." Oxidative Medicine and Cellular Longevity 2021, no. : 1-23.
Antioxidants could scavenge free radicals in the human body, and prevent and treat diseases induced by oxidative stress. In addition, antioxidants could delay the food spoilage, discoloration, and rancidity caused by oxidation in the food industry. Considering that the synthetic antioxidants may have some toxicities and side effects, natural antioxidants from food and medicinal plants could be a better candidate. In addition to the conventional extraction methods, several green and efficient extraction technologies have been developed, such as ultrasonic-assisted extraction, microwave-assisted extraction, enzymatic extraction, and supercritical fluid extraction. In order to comprehensively assess the antioxidant activity of extracts, in vitro and in vivo evaluation methods have been developed. As a result, antioxidant capacities of many foods and medicinal plants have been evaluated, such as vegetables, fruits, cereals, edible macro-fungi, medicinal herbs, flowers, and spices. In this chapter, we summarized the extraction, assessment, and resources of natural antioxidants in foods and medicinal plants, which are very helpful for full utilization of natural antioxidants.
Ao Shang; Min Luo; Ren-You Gan; Bang-Yan Li; Hang-Yu Li; Hua-Bin Li. Extraction and Assessment Methods as Well as Resources of Natural Antioxidants in Foods and Herbs. Reference Series in Phytochemistry 2021, 1 -30.
AMA StyleAo Shang, Min Luo, Ren-You Gan, Bang-Yan Li, Hang-Yu Li, Hua-Bin Li. Extraction and Assessment Methods as Well as Resources of Natural Antioxidants in Foods and Herbs. Reference Series in Phytochemistry. 2021; ():1-30.
Chicago/Turabian StyleAo Shang; Min Luo; Ren-You Gan; Bang-Yan Li; Hang-Yu Li; Hua-Bin Li. 2021. "Extraction and Assessment Methods as Well as Resources of Natural Antioxidants in Foods and Herbs." Reference Series in Phytochemistry , no. : 1-30.
Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.
Dan-Dan Zhou; Min Luo; Ao Shang; Qian-Qian Mao; Bang-Yan Li; Ren-You Gan; Hua-Bin Li. Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -17.
AMA StyleDan-Dan Zhou, Min Luo, Ao Shang, Qian-Qian Mao, Bang-Yan Li, Ren-You Gan, Hua-Bin Li. Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-17.
Chicago/Turabian StyleDan-Dan Zhou; Min Luo; Ao Shang; Qian-Qian Mao; Bang-Yan Li; Ren-You Gan; Hua-Bin Li. 2021. "Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies." Oxidative Medicine and Cellular Longevity 2021, no. : 1-17.
Hydrogels, polymeric network materials, are capable of swelling and holding the bulk of water in their three-dimensional structures upon swelling. In recent years, hydrogels have witnessed increased attention in food and biomedical applications. In this paper, the available literature related to the design concepts, types, functionalities, and applications of hydrogels with special emphasis on food applications was reviewed. Hydrogels from natural polymers are preferred over synthetic hydrogels. They are predominantly used in diverse food applications for example in encapsulation, drug delivery, packaging, and more recently for the fabrication of structured foods. Natural polymeric hydrogels offer immense benefits due to their extraordinary biocompatible nature. Hydrogels based on natural/edible polymers, for example, those from polysaccharides and proteins, can serve as prospective alternatives to synthetic polymer-based hydrogels. The utilization of hydrogels has so far been limited, despite their prospects to address various issues in the food industries. More research is needed to develop biomimetic hydrogels, which can imitate the biological characteristics in addition to the physicochemical properties of natural materials for different food applications.
Khalid Gul; Ren-You Gan; Cui-Xia Sun; Ge Jiao; Ding-Tao Wu; Hua-Bin Li; Ahmad Kenaan; Harold Corke; Ya-Peng Fang. Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels. Critical Reviews in Food Science and Nutrition 2021, 1 -16.
AMA StyleKhalid Gul, Ren-You Gan, Cui-Xia Sun, Ge Jiao, Ding-Tao Wu, Hua-Bin Li, Ahmad Kenaan, Harold Corke, Ya-Peng Fang. Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels. Critical Reviews in Food Science and Nutrition. 2021; ():1-16.
Chicago/Turabian StyleKhalid Gul; Ren-You Gan; Cui-Xia Sun; Ge Jiao; Ding-Tao Wu; Hua-Bin Li; Ahmad Kenaan; Harold Corke; Ya-Peng Fang. 2021. "Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels." Critical Reviews in Food Science and Nutrition , no. : 1-16.
Sweet tea (Lithocarpus polystachyus Rehd.) has been consumed as herbal tea to prevent and manage diabetes for a long time. Recent studies indicate that sweet tea is rich in a variety of bioactive compounds, especially a class of nonclassical flavonoids, dihydrochalcones. In order to provide a better understanding of sweet tea and its main dihydrochalcones on human health, this review mainly summarizes related literature in the recent ten years, with the potential molecular mechanisms emphatically discussed. Phlorizin, phloretin, and trilobatin, three natural sweeteners, are the main dihydrochalcones in sweet tea. In addition, sweet tea and its dihydrochalcones exhibit plenty of health benefits, such as antioxidant, anti-inflammatory, antimicrobial, cardioprotective, hepatoprotective, antidiabetic, and anticancer effects, which are associated with the regulation of different molecular targets and signaling pathways. Therefore, sweet tea, as a rare natural source of dihydrochalcones, can be processed and developed into nutraceuticals or functional foods, with the potential application in the prevention and management of certain chronic diseases.
Ao Shang; Hong-Yan Liu; Min Luo; Yu Xia; Xiao Yang; Hang-Yu Li; Ding-Tao Wu; Quancai Sun; Fang Geng; Hua-Bin Li; Ren-You Gan. Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits. Critical Reviews in Food Science and Nutrition 2020, 1 -18.
AMA StyleAo Shang, Hong-Yan Liu, Min Luo, Yu Xia, Xiao Yang, Hang-Yu Li, Ding-Tao Wu, Quancai Sun, Fang Geng, Hua-Bin Li, Ren-You Gan. Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits. Critical Reviews in Food Science and Nutrition. 2020; ():1-18.
Chicago/Turabian StyleAo Shang; Hong-Yan Liu; Min Luo; Yu Xia; Xiao Yang; Hang-Yu Li; Ding-Tao Wu; Quancai Sun; Fang Geng; Hua-Bin Li; Ren-You Gan. 2020. "Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits." Critical Reviews in Food Science and Nutrition , no. : 1-18.
The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
Gopalsamy Gandhi; Alan Vasconcelos; Ding-Tao Wu; Hua-Bin Li; Poovathumkal Antony; Hang Li; Fang Geng; Ricardo Gurgel; Narendra Narain; Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients 2020, 12, 2907 .
AMA StyleGopalsamy Gandhi, Alan Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal Antony, Hang Li, Fang Geng, Ricardo Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020; 12 (10):2907.
Chicago/Turabian StyleGopalsamy Gandhi; Alan Vasconcelos; Ding-Tao Wu; Hua-Bin Li; Poovathumkal Antony; Hang Li; Fang Geng; Ricardo Gurgel; Narendra Narain; Ren-You Gan. 2020. "Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies." Nutrients 12, no. 10: 2907.
In this study, the feasibility of improving the extraction yield of green tea antioxidant polyphenols by the combination of ultrasound-assisted extraction (UAE) and deep eutectic solvents (DESs) was investigated. Choline chloride (ChCl)-glycerol was selected as the best DES among 12 ChCl-based DESs to extract tea antioxidant polyphenols. Subsequently, the influences of extraction parameters on total phenolic content (TPC) values were investigated, and liquid/solid ratio, ultrasonic power, and ultrasonic time were optimized based on the response surface methodology. The optimal extraction conditions were a liquid to solid ratio of 36:1 (mL/g), ultrasonic power of 461.5 W, and ultrasonic time of 21 min, with the highest TPC value of 243 ± 7 mg gallic acid equivalent (mg GAE)/g dry weight (DW), which was 13% higher than that before optimization. In addition, under the optimal extraction conditions, tea polyphenolic extract exhibited higher antioxidant activity compared with conventional extraction methods. Four major catechins in the green tea extracts, including (−)-epicatechin (EC), (−)-epigallocatechin (EGC), (−)-epicatechin gallate (ECG) and (−)-epigallocatechin gallate (EGCG) were identified and quantified by high-performance liquid chromatography. In addition, scanning electron microscopy (SEM) analysis revealed that UAE-DES effectively disrupted the green tea leaf cells, thereby improving tea polyphenol yield. In summary, UAE-DES is an ideal green extraction method for the extraction of tea antioxidant polyphenols.
Qiong Luo; Jia-Rong Zhang; Hua-Bin Li; Ding-Tao Wu; Fang Geng; Harold Corke; Xin-Lin Wei; Ren-You Gan. Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis). Antioxidants 2020, 9, 785 .
AMA StyleQiong Luo, Jia-Rong Zhang, Hua-Bin Li, Ding-Tao Wu, Fang Geng, Harold Corke, Xin-Lin Wei, Ren-You Gan. Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis). Antioxidants. 2020; 9 (9):785.
Chicago/Turabian StyleQiong Luo; Jia-Rong Zhang; Hua-Bin Li; Ding-Tao Wu; Fang Geng; Harold Corke; Xin-Lin Wei; Ren-You Gan. 2020. "Green Extraction of Antioxidant Polyphenols from Green Tea (Camellia sinensis)." Antioxidants 9, no. 9: 785.
In this study, the effects of microwave-assisted extraction conditions on antioxidant capacity of sweet tea (Lithocarpus polystachyus Rehd.) were studied and the antioxidants in the extract were identified. The influences of ethanol concentration, solvent-to-sample ratio, microwave power, extraction temperature and extraction time on Trolox equivalent antioxidant capacity (TEAC) value, ferric reducing antioxidant power (FRAP) value and total phenolic content (TPC) were investigated by single-factor experiments. The response surface methodology (RSM) was used to study the interaction of three parameters which had significant influences on antioxidant capacity including ethanol concentration, solvent-to-sample ratio and extraction time. The optimal conditions for the extraction of antioxidants from sweet tea were found as follows—ethanol concentration of 58.43% (v/v), solvent-to-sample ratio of 35.39:1 mL/g, extraction time of 25.26 min, extraction temperature of 50 ℃ and microwave power of 600 W. The FRAP, TEAC and TPC values of the extract under the optimal conditions were 381.29 ± 4.42 μM Fe(II)/g dry weight (DW), 613.11 ± 9.32 μM Trolox/g DW and 135.94 ± 0.52 mg gallic acid equivalent (GAE)/g DW, respectively. In addition, the major antioxidant components in the extract were detected by high-performance liquid chromatography with diode array detection (HPLC-DAD), including phlorizin, phloretin and trilobatin. The crude extract could be used as food additives or developed into functional food for the prevention and management of oxidative stress-related diseases.
Ao Shang; Min Luo; Ren-You Gan; Xiao-Yu Xu; Yu Xia; Huan Guo; Yi Liu; Hua-Bin Li. Effects of Microwave-Assisted Extraction Conditions on Antioxidant Capacity of Sweet Tea (Lithocarpus polystachyus Rehd.). Antioxidants 2020, 9, 678 .
AMA StyleAo Shang, Min Luo, Ren-You Gan, Xiao-Yu Xu, Yu Xia, Huan Guo, Yi Liu, Hua-Bin Li. Effects of Microwave-Assisted Extraction Conditions on Antioxidant Capacity of Sweet Tea (Lithocarpus polystachyus Rehd.). Antioxidants. 2020; 9 (8):678.
Chicago/Turabian StyleAo Shang; Min Luo; Ren-You Gan; Xiao-Yu Xu; Yu Xia; Huan Guo; Yi Liu; Hua-Bin Li. 2020. "Effects of Microwave-Assisted Extraction Conditions on Antioxidant Capacity of Sweet Tea (Lithocarpus polystachyus Rehd.)." Antioxidants 9, no. 8: 678.
In this study, the efficiency of microwave-assisted hydro-distillation (MAHD) to extract essential oil from Cinnamomum camphora leaf, and the recovery of polyphenols from extract fluid were investigated. The effects of microwave power, liquid-to-material ratio, and extraction time on the extraction efficiency were studied by a single factor test as well as the response surface methodology (RSM) based on the central composite design method. The optimal extraction conditions were a microwave power of 786.27 W, liquid-to-material ratio of 7.47:1 mL/g, and extraction time of 35.57 min. The yield of essential oil was 3.26 ± 0.05% (w/w), and the recovery of polyphenols was 4.97 ± 0.02 mg gallic acid equivalent/g dry weight under the optimal conditions. Furthermore, the comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS) was used to characterize the essential oils of fresh and fallen leaves, and 159 individual compounds were tentatively identified, accounting for more than 89.68 and 87.88% of the total contents, respectively. The main ingredients include sabinene, l-β-pinene, β-myrcene, α-terpineol, 3-heptanone, and β-thujene, as well as -terpineol and 3-heptanone, which were first identified in C. camphora essential oil. In conclusion, the MAHD method could extract essential oil from C. camphora with high efficiency, and the polyphenols could be obtained from the extract fluid at the same time, improving the utilization of C. camphora leaf.
Ao Shang; Ren-You Gan; Jia-Rong Zhang; Xiao-Yu Xu; Min Luo; Hong-Yan Liu; Hua-Bin Li. Optimization and Characterization of Microwave-Assisted Hydro-Distillation Extraction of Essential Oils from Cinnamomum camphora Leaf and Recovery of Polyphenols from Extract Fluid. Molecules 2020, 25, 3213 .
AMA StyleAo Shang, Ren-You Gan, Jia-Rong Zhang, Xiao-Yu Xu, Min Luo, Hong-Yan Liu, Hua-Bin Li. Optimization and Characterization of Microwave-Assisted Hydro-Distillation Extraction of Essential Oils from Cinnamomum camphora Leaf and Recovery of Polyphenols from Extract Fluid. Molecules. 2020; 25 (14):3213.
Chicago/Turabian StyleAo Shang; Ren-You Gan; Jia-Rong Zhang; Xiao-Yu Xu; Min Luo; Hong-Yan Liu; Hua-Bin Li. 2020. "Optimization and Characterization of Microwave-Assisted Hydro-Distillation Extraction of Essential Oils from Cinnamomum camphora Leaf and Recovery of Polyphenols from Extract Fluid." Molecules 25, no. 14: 3213.
In recent years, obesity has become a global public health issue. It is closely associated with the occurrence of several chronic diseases, such as diabetes and cardiovascular diseases. Some edible and medicinal plants show anti-obesity activity, such as fruits, vegetables, spices, legumes, edible flowers, mushrooms, and medicinal plants. Numerous studies have indicated that these plants are potential candidates for the prevention and management of obesity. The major anti-obesity mechanisms of plants include suppressing appetite, reducing the absorption of lipids and carbohydrates, inhibiting adipogenesis and lipogenesis, regulating lipid metabolism, increasing energy expenditure, regulating gut microbiota, and improving obesity-related inflammation. In this review, the anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products. Further studies should focus on the exploration of safer plants with anti-obesity activity and the identification of specific anti-obesity mechanisms.
Ao Shang; Ren-You Gan; Xiao-Yu Xu; Qian-Qian Mao; Pang-Zhen Zhang; Hua-Bin Li. Effects and mechanisms of edible and medicinal plants on obesity: an updated review. Critical Reviews in Food Science and Nutrition 2020, 61, 2061 -2077.
AMA StyleAo Shang, Ren-You Gan, Xiao-Yu Xu, Qian-Qian Mao, Pang-Zhen Zhang, Hua-Bin Li. Effects and mechanisms of edible and medicinal plants on obesity: an updated review. Critical Reviews in Food Science and Nutrition. 2020; 61 (12):2061-2077.
Chicago/Turabian StyleAo Shang; Ren-You Gan; Xiao-Yu Xu; Qian-Qian Mao; Pang-Zhen Zhang; Hua-Bin Li. 2020. "Effects and mechanisms of edible and medicinal plants on obesity: an updated review." Critical Reviews in Food Science and Nutrition 61, no. 12: 2061-2077.