Global greening and its eco-environmental outcomes are getting mounting international focus. The important contribution of China to the global greening is highly appreciated. However, the basic driving forces are still elusive. The Loess Plateau (LP) and Three-River Source Region (TRSR) were chased as study areas in Northern China. The prior one represents the region experiencing intensive human interventions from ecological engineering projects, while the latter is a typical region that is experiencing faster climate change. Hypothesized to be driven by a disproportionate rate of human activities and climates, also being regions of typical large-scale ecological engineering projects, the study goal is to identify the actual driving forces on vegetation dynamics in these two regions. Trend analysis, correlation analysis, and residual trend-based method (RESTREND) were utilized to understand the relationships between climate variability, human activities, and vegetation dynamics. The spatiotemporal variations of vegetation from 1982 to 2019 were evaluated and the respective impacts of climatic and anthropogenic factors on vegetation dynamics were disentangled. Indicating apparent vegetation restoration in LP and TRSR, the results depict that annual LAI has remarkably increased during the 38 years. Temperature and precipitation promoted vegetation growth, whereas the solar radiation and vapor pressure deficit hampered it. After implementing the ecological engineering projects, the primary climatic factor changed from temperature to precipitation. Meanwhile, human activities act as the major driving factor in vegetation greening in the entire study area, with a contribution rate exceeding 70%. This information highlights that ecological engineering can significantly reduce the risks of ecosystem degradation and effectively restore vegetation, especially in ecologically sensitive and vulnerable areas.