Objectives:To investigate the correlation between iodine attenuation of dual-energy CT (DECT) and histopathology of surgically resected primary lung cancers.Methods:We reviewed the medical records, post-operative pathological records, and preoperative DECT images of patients who underwent surgical lung resection for primary lung cancer. After injection of iodinated contrast media, arterial and delayed phases were scanned using 140-kV and 80-kV tube voltages. Three-dimensional iodine attenuation (iodine volume) of primary tumors was calculated using lung nodule application software.Results:A total of 60 patients (37 males, 23 females; age range, 39-84 years; mean age, 69 years) with 62 lung cancers were analyzed. The resected tumors were histopathologically classified into well-differentiated (G1; n=20), moderately-differentiated (G2; n=29), poorly-differentiated (G3; n=9), and undifferentiated (G4; n=4) groups by degree of tumor differentiation (DTD). The mean±standard deviation of iodine volume at the de...

Three-dimensional volume assessment of the solid component of part-solid nodules using computer-aided diagnosis may improve prediction of postoperative recurrence and prognosis compared with the conventional measurement of tumor diameter. PurposeTo investigate the relationship between the postoperative prognosis of patients with part-solid non–small cell lung cancer and the solid component size acquired by using three-dimensional (3D) volumetry software on multidetector computed tomographic (CT) images.Materials and MethodsA retrospective study by using preoperative multidetector CT data with 0.5-mm section thickness, clinical records, and pathologic reports of 96 patients with primary subsolid non–small cell lung cancer (47 men and 49 women; mean age ± standard deviation, 66 years ± 8) were reviewed. Two radiologists measured the two-dimensional (2D) maximal solid size of each nodule on an axial image (hereafter, 2D MSSA), the 3D maximal solid size on multiplanar reconstructed images (hereafter, 3D MSSMPR), and the 3D solid volume of greater than 0 HU (hereafter, 3D SV0HU) within each nodule. The correlations between the postoperative recurrence and the effects of clinical and pathologic characteristics, 2D MSSA, 3D MSSMPR, and 3D SV0HU a...