Cloud computing is considered suitable for organizations thanks to its flexibility and the provision of digital services via the Internet. The cloud provides nearly limitless computing resources on demand without any upfront costs or long-term contracts, enabling organizations to meet their computing needs more economically. Furthermore, cloud computing provides higher security, scalability, and reliability levels than traditional computing solutions. The efficiency of the platform affects factors such as Quality of Service (QoS), congestion, lifetime, energy consumption, dependability, and scalability. Load balancing refers to managing traffic flow to spread it across several channels. Asymmetric network traffic results in increased traffic processing, more congestion on specific routes, and fewer packets delivered. The paper focuses on analyzing the use of the meta-optimization algorithm based on the principles of natural selection to solve the imbalance of loads in cloud systems. To sum up, it offers a detailed literature review on the essential meta-heuristic algorithms for load balancing in cloud computing. The study also assesses and analyses meta-heuristic algorithm performance in load balancing, as revealed by past studies, experiments, and case studies. Key performance indicators encompass response time, throughput, resource utilization, and scalability, and they are used to assess how these algorithms impact load balance efficiency.

Maintaining security in communication networks has long been a major concern. This issue has become increasingly crucial due to the emergence of new communication architectures like the Internet of Things (IoT) and the advancement and complexity of infiltration techniques. For usage in networks based on the Internet of Things, previous intrusion detection systems (IDSs), which often use a centralized design to identify threats, are now ineffective. For the resolution of these issues, this study presents a novel and cooperative approach to IoT intrusion detection that may be useful in resolving certain current security issues. The suggested approach chooses the most important attributes that best describe the communication between objects by using Black Hole Optimization (BHO). Additionally, a novel method for describing the network’s matrix-based communication properties is put forward. The inputs of the suggested intrusion detection model consist of these two feature sets. The suggested technique splits the network into a number of subnets using the software-defined network (SDN). Monitoring of each subnet is done by a controller node, which uses a parallel combination of convolutional neural networks (PCNN) to determine the presence of security threats in the traffic passing through its subnet. The proposed method also uses the majority voting approach for the cooperation of controller nodes in order to more accurately detect attacks. The findings demonstrate that, in comparison to the prior approaches, the suggested cooperative strategy can detect assaults in the NSLKDD and NSW-NB15 datasets with an accuracy of 99.89 and 97.72 percent, respectively. This is a minimum 0.6 percent improvement.

Diabetic retinopathy is one of the most common microangiopathy in diabetes, essentially caused by abnormal blood glucose metabolism resulting from insufficient insulin secretion or reduced insulin activity. Epidemiological survey results show that about one third of diabetes patients have signs of diabetic retinopathy, and another third may suffer from serious retinopathy that threatens vision. However, the pathogenesis of diabetic retinopathy is still unclear, and there is no systematic method to detect the onset of the disease and effectively predict its occurrence. In this study, we used medical detection data from diabetic retinopathy patients to determine key biomarkers that induce disease onset through back propagation neural network algorithm and hierarchical clustering analysis, ultimately obtaining early warning signals of the disease. The key markers that induce diabetic retinopathy have been detected, which can also be used to explore the induction mechanism of disease occurrence and deliver strong warning signal before disease occurrence. We found that multiple clinical indicators that form key markers, such as glycated hemoglobin, serum uric acid, alanine aminotransferase are closely related to the occurrence of the disease. They respectively induced disease from the aspects of the individual lipid metabolism, cell oxidation reduction, bone metabolism and bone resorption and cell function of blood coagulation. The key markers that induce diabetic retinopathy complications do not act independently, but form a complete module to coordinate and work together before the onset of the disease, and transmit a strong warning signal. The key markers detected by this algorithm are more sensitive and effective in the early warning of disease. Hence, a new method related to key markers is proposed for the study of diabetic microvascular lesions. In clinical prediction and diagnosis, doctors can use key markers to give early warning of individual diseases and make early intervention.

Traffic congestion is a major challenge in urban life, and traffic flow prediction, as a critical task in intelligent transportation management, can effectively alleviate congestion and enhance traffic control efficiency. Although deep learning models have achieved significant progress in traffic flow prediction, most existing studies focus on capturing dynamic spatiotemporal features, with insufficient attention to the pivotal role of historical data's periodic characteristics in forecasting. To address this, we proposed a Transformer‐based Dynamic Graph Convolutional Network (T‐DGCN), which significantly improves prediction accuracy by integrating historical periodic features and real‐time dynamic variations. T‐DGCN employs the self‐attention mechanism of Transformer to capture temporal dependencies and combines dynamic graph convolutional networks to extract spatial features, thereby comprehensively modelling spatiotemporal dynamics. Experiments on the real highway datasets from California (PeMSD4 and PeMSD8) show that T‐DGCN outperforms state‐of‐the‐art models across multiple time horizons. On the PeMSD4 dataset, it reduces the MAE and RMSE by an average of 12.9% and 5.2% across the 15 min, 30 min, and 60 min prediction horizons, respectively. On the PeMSD8 dataset, it reduces the MAE and RMSE results by approximately 8.8% and 5.7% on average, respectively.

Complex diseases may not always progress in a gradual manner. In the early stages of complex diseases, obvious symptoms are usually not observable, but there is a commonality: there is a brief state of predisease between the progression from normal state to disease state, which usually includes three stages: normal state, critical state of predisease, and disease state. Identifying this critical state, especially with a single sample from an individual, remains a difficult task. In this study, we applied three methods, i.e., single-sample Jensen–Shannon Divergence (sJSD), network information gain (NIG), and temporal network flow entropy (TNFE) method, to a simulated dataset and type 2 diabetes (GSE13268 and GSE13269). Three different methods were utilized to create indexes, including the Inconsistency Index (ICI), NIG, and TNFE, to measure the overall disruption caused by individual samples compared to a set of reference samples. Changes in these indexes were used to identify critical states during the progression of the disease. Results from the numerical simulations show the effectiveness of the three methods. All the methods can detect two critical states based on a single sample, which are respectively at 8 weeks and 16 weeks for GSE13268 and at 4 weeks and 16 weeks for GSE13269, indicating the critical states before deterioration can be detected and the dynamic network biomarkers (DNBs) can be identified successfully. But there are differences in the sensitivity of predictive indicators based on the three methods. The identified dynamic network biomarkers are also significantly different. In addition, the computational principles of the three methods are compared. The proposed three methods can effectively detect the critical state and identify the DNB, solely based on a single sample. The three methods are data-driven and model-free on an individual basis. sJSD method is more sensitive to the critical state, while NIG and TNFE methods are more robust and effective. They can therefore not only help future studies of personalized disease diagnosis but also provide a better insight into clinical practice.

Background: Diabetic retinopathy is one of the most common microangiopathy in diabetes, essentially caused by abnormal blood glucose metabolism resulting from insufficient insulin secretion or reduced insulin activity. Epidemiological survey results show that about one third of diabetes patients have signs of diabetic retinopathy, and another third may suffer from serious retinopathy that threatens vision. However, the pathogenesis of diabetic retinopathy is still unclear, and there is no systematic method to detect the onset of the disease and effectively predict its occurrence. Methods: In this study, we used medical detection data from diabetic retinopathy patients to determine key biomarkers that induce disease onset through BP neural network algorithm and hierarchical clustering analysis, ultimately obtaining early warning signals of the disease. Results: The key markers that induce diabetic retinopathy have been detected, which can also be used to explore the induction mechanism of disease occurrence and deliver strong warning signal before disease occurrence. We found that multiple clinical indicators that form key markers, such as glycated hemoglobin, serum uric acid, alanine aminotransferase are closely related to the occurrence of the disease. They respectively induced disease from the aspects of the individual lipid metabolism, cell oxidation reduction, bone metabolism and bone resorption and cell function of blood coagulation. Conclusions: The key markers that induce diabetic retinopathy complications do not act independently, but form a complete module to coordinate and work together before the onset of the disease, and transmit a strong warning signal. The key markers detected by this algorithm are more sensitive and effective in the early warning of disease. Hence, a new method related to key markers is proposed for the study of diabetic microvascular lesions. In clinical prediction and diagnosis, doctors can use key markers to give early warning of individual diseases and make early intervention.