Objective: PM_2.5, which is a major contributor to air pollution, has large effects on lung cancer mortality. We want to analyse the long-term trends in lung cancer burden attributable to PM_2.5 exposure and provide evidence that can be used for preventive measures and health resource planning. Methods: Mortality data related to lung cancer were obtained from the Global Burden of Disease (GBD) 2019 project. A joinpoint regression analysis was used to assess the magnitude and direction of the trends in mortality from 1990 to 2019, and the age-period-cohort method was used to analyse the temporal trends in the mortality rate of lung cancer attributable to PM_2.5 exposure by age, period, and cohort. Results: From 1990 to 2019, the age-standardized mortality rate (ASMR) attributable to PM_2.5 exposure trended slowly upwards, and the ASMR due to ambient PM_2.5 exposure (APE) increased significantly, that due to household PM_2.5 exposure (HPE) decreased. The longitudinal age curves show that the mortality rates due to PM_2.5 exposure among younger individuals were low, and they significantly increased from their levels among those in the 45–49 age group to their levels among those in the over-85 age group. From 1990 to 2019, the period RRs due to APE increased, but those due to HPE decreased. Similar trends were observed in the cohort RRs. The overall net drift per year attributable to PM_2.5 exposure was below 0. The local drift values increased with age and were above 0 for the over-80 age groups. The overall net drifts per year were above zero for APE and below zero for HPE. The corresponding results among males were higher than those among females. Conclusions: In China, the type of air pollution responsible for lung cancer has changed from household air pollution to ambient air pollution. PM_2.5 exposure is more harmful among males and older people. Ambient air pollution should be emphasized, and China should strengthen its implementation of effective public policies and other interventions.

There is no consensus on the role of bilirubin in acute ischemic stroke. Higher levels of serum bilirubin may provide a treatment advantage in oxidative-stress-mediated diseases but also may simply reflect the strength of the oxidative stress. As of 28 February 2022, the relevant studies were selected from four databases (PubMed, Web of science, Cochrane, and CNKI) through a retrieval strategy, and strict literature screening and quality evaluation were carried out. The dose–response relationship was fitted with a restricted cubic splines function. We found that the serum total bilirubin level and the direct bilirubin level were positively correlated with the severity of ischemic stroke. The direct bilirubin level was linearly correlated with the severity of stroke (P for non-linearity = 0.55), and the direct bilirubin increase of 1 μmol/L may be related to the 1% increase in the possibility of having moderate or severe ischemic stroke. High bilirubin levels are associated with stroke severity in patients with ischemic stroke and may serve as a marker of the intensity of initial oxidative stress.

To evaluate the global scientific output of the research on whole-body vibration training (WBVT) and explore the current status and trends in this field over the past decades using bibliometric methods, we retrieved the literature related to WBVT from 2000 to the present in the Web of Science Core Collection (WoSCC). We analyzed annual publications, citations, countries, organizations, productive authors, and source 14 journals by the Web of Science online bibliometric analysis. We visualized the WBVT research trends and explored influential organizations and authors through VOSviewer. Then, we constructed a citation chronology map by HistCite to obtain the knowledge base of this field and made a primary citation path analysis by Pajek. Finally, we mined the hot spots of WBVT by BICOMB and gCLUTO. Overall, there were 1,629 publications included in this study between 2000 and 2022. The United States contributed the most publications in this field, and the country with the most active partnership was Spain. The University of Cologne ranked highest among top productive organizations. Bernardo-Filho, Mario, from Universidade do Estado do Rio de Janeiro, ranked first among the top productive authors. The Journal of Strength and Conditioning Research topped the list of journals with the most publications on WBVT by a wide margin. The WBVT research field started from Rittweger’s study on the acute physiological effects of WBVT in 2000, which was divided into two stages. The first stage focused on improving athletic ability, and the second stage gradually turned to the application in medicine. A keyword analysis showed the exercise rehabilitation of several aging chronic diseases was the research trend and hot spot of WBVT. The current study provided a time-based development and a global network hub for WBVT research, contributing to identifying core target diseases of WBVT and providing various insights for researchers in the future.