Marjolein Lugtenberg

Dr. Marjolein Lugtenberg


Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 December 2022 in Archives of Dermatological Research
Verified
Journal Article
Open access
PDF file
TSTobias Sangers
Tobias Sangers
MWMarlies Wakkee
Marlies Wakkee
FMFolkert J. Moolenburgh
Folkert J. Moolenburgh
TNTamar Nijsten
Tamar Nijsten
MLMarjolein Lugtenberg
Marjolein Lugtenberg
Recent studies show promising potential for artificial intelligence (AI) to assist healthcare providers (HCPs) in skin cancer care. The aim of this study is to explore the views of dermatologists and general practitioners (GPs) regarding the successful implementation of AI when assisting HCPs in skin cancer care. We performed a qualitative focus group study, consisting of six focus groups with 16 dermatologists and 17 GPs, varying in prior knowledge and experience with AI, gender, and age. An in-depth inductive thematic content analysis was deployed. Perceived benefits, barriers, and preconditions were identified as main themes. Dermatologists and GPs perceive substantial benefits of AI, particularly an improved health outcome and care pathway between primary and secondary care. Doubts about accuracy, risk of health inequalities, and fear of replacement were among the most stressed barriers. Essential preconditions included adequate algorithm content, sufficient usability, and accessibility of AI. In conclusion, dermatologists and GPs perceive significant benefits from implementing AI in skin cancer care. However, to successfully implement AI, key barriers need to be addressed. Efforts should focus on ensuring algorithm transparency, validation, accessibility for all skin types, and adequate regulation of algorithms. Simultaneously, improving knowledge about AI could reduce the fear of replacement.

4 October 2024 in British Journal of Dermatology
Verified
Journal Article
Open access
PDF file
NKNadia C W Kamminga
Nadia C W Kamminga
JKJune E C Kievits
June E C Kievits
PPPeter W Plaisier
Peter W Plaisier
JBJako S Burgers
Jako S Burgers
AVAstrid M van der Veldt
Astrid M van der Veldt
TNTamar Nijsten
Tamar Nijsten
Background: Large language models (LLMs) have a potential role in providing adequate patient information. Objectives: To compare the quality of LLM responses with established Dutch patient information resources (PIRs) in answering patient questions regarding melanoma. Methods: Responses from ChatGPT versions 3.5 and 4.0, Gemini, and three leading Dutch melanoma PIRs to 50 melanoma-specific questions were examined at baseline and for LLMs again after 8 months. Outcomes included (medical) accuracy, completeness, personalization, readability and, additionally, reproducibility for LLMs. Comparative analyses were performed within LLMs and PIRs using Friedman’s Anova, and between best-performing LLMs and gold-standard (GS) PIRs using the Wilcoxon signed-rank test. Results: Within LLMs, ChatGPT-3.5 demonstrated the highest accuracy (P = 0.009). Gemini performed best in completeness (P < 0.001), personalization (P = 0.007) and readability (P < 0.001). PIRs were consistent in accuracy and completeness, with the general practitioner’s website excelling in personalization (P = 0.013) and readability (P < 0.001). The best-performing LLMs outperformed the GS-PIR on completeness and personalization, yet it was less accurate and less readable. Over time, response reproducibility decreased for all LLMs, showing variability across outcomes. Conclusions: Although LLMs show potential in providing highly personalized and complete responses to patient questions regarding melanoma, improving and safeguarding accuracy, reproducibility and accessibility is crucial before they can replace or complement conventional PIRs.

14 June 2022 in British Journal of Dermatology
Verified
Journal Article
Open access
NKNadia C.W. Kamminga
Nadia C.W. Kamminga
Astrid A.M. van der VeldtAstrid A.M. van der Veldt
Astrid A.M. van der Veldt
MJMargot C.W. Joosen
Margot C.W. Joosen
KJKarlijn de Joode
Karlijn de Joode
AJArjen Joosse
Arjen Joosse
MLMarjolein Lugtenberg
Marjolein Lugtenberg
Background: Immune checkpoint inhibitors (ICIs) have significantly improved the overall survival of patients with metastatic melanoma. It is unclear how the growing group of metastatic melanoma survivors resume their lives after treatment, and which needs they have regarding survivorship care (SSC). Objectives: To gain an in-depth understanding of metastatic melanoma survivors’ experiences of resuming life after ICIs and their associated SSC needs. Methods: A qualitative study was conducted among 20 patients with metastatic melanoma in whom ICIs had been discontinued after ongoing tumour response. One focus group (n = 9) was held, which was complemented by 11 individual interviews. Purposive sampling was used to select a variable sample in terms of sex, age, time since discontinuation of ICIs, and perceived impact of the disease. A topic guide was used to structure the (group) interviews, which were transcribed verbatim and analysed in a thematic content analysis, using several phases of coding. Results: In resuming life after ICIs, the prognosis switch often caused mixed feelings among patients, mainly because of the uncertainty about the future. Demands and expectations from self and others, persistent complaints and new problems in different life domains often make it challenging to proceed with life as it was prior to metastatic cancer. Patients indicated they needed to find a new balance, which included learning to cope with uncertainty and a changed perspective on life and close relationships. In terms of SSC needs, patients particularly stressed the need for more tailored patient information, available at one location. In addition, they emphasized the need to know who to turn to in case of questions and indicated the need for psychosocial support, also for their close relatives. Conclusions: Metastatic melanoma survivors face various challenges in resuming life after ICIs and are left with several unmet SSC needs. Efforts should be focused on offering psychosocial supportive care in addition to medical care, from diagnosis onwards, taking into account the patient’s close relatives. A single point of contact and personalized survivorship care plan (SCP) could be of added value in guiding them through the patient journey, which is, given its multidisciplinary nature, particularly important in melanoma care. What is already known about this topic? Since the introduction of immune checkpoint inhibitors (ICIs) the overall survival of patients with metastatic melanoma has improved significantly, leading to a growing group of melanoma survivors. Melanoma survivors may face various problems and challenges in resuming life after treatment, which may be associated with unmet survivorship care (SSC) needs. An in-depth understanding of their experiences with resuming life and the associated SSC needs is currently lacking. What does this study add? Metastatic melanoma survivors experience various challenges after immunotherapy, from the uncertain prognosis switch to the struggle of finding a new balance in life. Besides negative aspects, such as complaints in different life domains, the patient journey is often accompanied by positive outcomes, for example a changed perspective on life. They stress the need for tailored patient information and broader supportive care, also for their close relatives. What are the clinical implications of this work? In addition to medical care, efforts should be focused on offering psychosocial supportive care, including return-to-work issues, from diagnosis onwards, ideally taking into account the patient’s close relatives. To guide them through the patient journey, a single point of contact and a personalized survivorship care plan (SCP) could be of added value. The latter is particularly important in melanoma care, given its multidisciplinary nature.

STSuzanne van den Toren
Suzanne van den Toren
AGAmy van Grieken
Amy van Grieken
MLMarjolein Lugtenberg
Marjolein Lugtenberg
MBMirte Boelens
Mirte Boelens
Hein RaatHein Raat
Hein Raat
This study aimed to get insight into adolescents’ views on help-seeking for emotional and behavioral problems. Fourteen focus groups were conducted. Two vignettes, depicting one healthy adolescent with few issues and one adolescent with severe psychosocial problems, were used to structure the focus groups. The focus groups were framed within a youth help-seeking model. Adolescents (mean age of 15.0 years) generally reported seeking help from friends or the internet for mild issues and from a person they trust like a parent or school mentor, for more severe problems. Adolescents correctly recognized the issues in vignette one as surmountable and the problems in vignette two as severe. A bond of trust with a help source was regarded as the main facilitator for the decision to seek help. Adolescents reported a preference for help sources who clearly displayed their expertise for the issue at hand and for informal help-sources, particularly friends.

2 February 2022 in Archives of Dermatological Research
Verified
Journal Article
Open access
PDF file
LWLinde E. M. de Wijs
Linde E. M. de Wijs
SESven van Egmond
Sven van Egmond
ADArjan C. A. Devillers
Arjan C. A. Devillers
TNTamar Nijsten
Tamar Nijsten
DHDirkJan Hijnen
DirkJan Hijnen
MLMarjolein Lugtenberg
Marjolein Lugtenberg
To optimally tailor atopic dermatitis (AD) care to patients’ needs, especially considering the many emerging therapeutic options, insight into patients’ needs and preferences regarding AD care is needed. To explore patients’ needs and preferences regarding AD care, a qualitative study consisting of three focus groups with a total of 20 adult AD patients was conducted. All sessions were transcribed verbatim and inductively analyzed using several phases of coding to create an overview of patients’ needs and preferences. AD patients emphasized the need for a patient-tailored approach in all identified aspects of AD care. With regard to consultations, patients stressed the need for a personal approach and increased recognition of the disease impact, which should mainly be determined by patients. With regard to the organization of AD care, the need for psychosocial and medical supportive care as well as quick access to health-care providers during disease flares was emphasized. Within the decision-making process, patients indicated that the provided information, the role of the patient and physician, whether or not treatment goals should be set, and decisive factors for indication and feasibility of novel therapies should be patient dependent. AD care should be patient tailored with increased attention for the psychosocial burden, as well as better access to health care during disease flares. To provide patient-tailored care, the personal situation, needs, and preferences of the patient should be taken into account in the therapeutic decision-making process, with respect for the autonomy of the patient.

STSuzanne van den Toren
Suzanne van den Toren
AGAmy van Grieken
Amy van Grieken
WMWico C. Mulder
Wico C. Mulder
YVYvonne Vanneste
Yvonne Vanneste
MLMarjolein Lugtenberg
Marjolein Lugtenberg
Hein RaatHein Raat
Hein Raat
This study examines the association between school absenteeism, health-related quality of life (HRQOL) and happiness among young adults aged 16–26 years attending vocational education. Cross-sectional data from a survey among 676 young adults were analyzed. School absenteeism was measured by the self-reported number of sick days in the past eight weeks and hours of truancy in the past four weeks. HRQOL was measured by the 12-item Short Form Health Survey; physical and mental component summary scores were calculated. General happiness was assessed on a scale of 0–10, higher scores indicating greater happiness. Linear regression analyses were performed. The study population had a mean age of 18.5 years (SD 2.2); 26.1% were boys. Young adults with ≥5 sick days or ≥6 h of truancy reported lower mental HRQOL compared to young adults without sickness absence or truancy (p < 0.05). Young adults with 1–4 and ≥5 sick days reported lower physical HRQOL compared to young adults who had not reported to be sick (p < 0.05). Young adults with 1–5 h and ≥6 h of truancy reported higher physical HRQOL compared to young adults who were not truant (p < 0.05). No associations were observed between school absence and happiness. Lower self-reported mental HRQOL was observed among young adults with more school absenteeism due to sickness or truancy. Sickness absence was additionally associated with lower physical HRQOL.