Malva parviflora L., Little mallow, has been traditionally used as an alternative food source. It acts as a medicinal herb containing a potential source of mucilage thus herein; we aimed to assess the toxicity, anti-inflammatory, antitussive and gastro-protective actions of M. parviflora mucilage extracted from its leaves (MLM) and fruit (MFM). Toxicity studies were investigated by in vitro hemolytic assay whereas acute anti-inflammatory and antitussive activities were assessed by carrageenan-induced paw edema and sulphur dioxide induced cough model in rats, respectively. Gastro-protective effects were studied using ethanol induced acute and chronic gastric ulcer rat models. Their metabolic profiles were determined using gas chromatography. The results revealed that MLM and MFM were non-toxic towards human erythrocytes and their lethal doses were found to be greater than 5 g/kg. Pretreatment with MLM (500 mg/kg) and MFM (500 mg/kg) significantly reduced the carrageenan-induced paw thickness (p < 0.001). Maximum edema inhibition (%) was observed at 4 h in diclofenac sodium (39.31%) followed by MLM (27.35%) and MFM (15.68%). Animals pretreated with MLM (500 mg/kg) significantly lower the cough frequency in SO₂ gas induced cough models in contrast to control. Moreover, MLM at doses of 250 and 500 mg/kg reduced the ethanol induced gastric mucosal injuries in acute gastric ulcer models presenting ulcer inhibition of 23.04 and 38.74%, respectively. The chronic gastric ulcer model MFM (500 mg/kg) demonstrated a remarkable gastro-protective effect showing 63.52% ulcer inhibition and results were closely related to standard drug sucralfate. In both models, MLM and MFM decreased gastric juice volume and total acidity in addition to an increased gastric juice pH and gastric mucous content justifying an anti-secretary role of this mucilage that was further confirmed by histopathological examination. Meanwhile, GC analyses of the mucilage revealed their richness with natural as well as acidic monosaccharides. It is concluded that MLM and MFM can be used therapeutically for the management of inflammation, cough and gastric ulcer.

Aim: Pathological findings in laparoscopic sleeve Gastrectomy specimens.Setting: Doctor’s Hospital Clinical lab Lahore.Method: Retrospectively demographic data and biopsy report of patient who go through surgicalprocedure of laparoscopic sleeve gastrectomy since 1st Jan 2016 to May2024 were obtained from clinicallaboratory of Doctor’s Hospital Lahore.Result: A total of 101 patients who go through surigical procedure of laparoscopic sleeve gastrectomy.Between these patients, 53 (52.5%) were female along with 48 (47.5%) were male. Age of patient variesfrom 15 to 62 years and the majority of the patient were in 41 to 50 years of age. The Histologicalsections of specimens revealed that lymphoplasmacytic infiltrate in lamina propria were the mostcommon histopathological finding (52,51.5%) followed by no remarkable histopathologicalfindings(22,21.8%).The other pathology found were H-pylori induced gastritis(33,32.7%) and activegastritis(10,9.9%).Conclusion: Our findings reveals that need for routinely performing biopsy reporting of laparoscopicsleeve gastrectomy specimens. The study also highlights lympho-plasmacytic infiltrtate and H-pylori asthe other most common pathological finding.