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Inflammation is an emerging risk factor for prostate cancer based largely on evidence from animal models and histopathologic observations. However, findings from patho-epidemiologic studies of intraprostatic inflammation and prostate cancer have been less supportive, with inverse associations observed in many studies of intraprostatic inflammation and prostate cancer diagnosis. Here, we propose collider stratification bias as a potential methodologic explanation for these inverse findings and provide strategies for conducting future etiologic studies of intraprostatic inflammation and prostate cancer.
Marvin E. Langston; Karen S. Sfanos; Saira Khan; Trang Q. Nguyen; Angelo M. De Marzo; Elizabeth A. Platz; Siobhan Sutcliffe. Why Do Epidemiologic Studies Find an Inverse Association Between Intraprostatic Inflammation and Prostate Cancer: A Possible Role for Colliding Bias? Cancer Epidemiology Biomarkers & Prevention 2021, 30, 255 -259.
AMA StyleMarvin E. Langston, Karen S. Sfanos, Saira Khan, Trang Q. Nguyen, Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe. Why Do Epidemiologic Studies Find an Inverse Association Between Intraprostatic Inflammation and Prostate Cancer: A Possible Role for Colliding Bias? Cancer Epidemiology Biomarkers & Prevention. 2021; 30 (2):255-259.
Chicago/Turabian StyleMarvin E. Langston; Karen S. Sfanos; Saira Khan; Trang Q. Nguyen; Angelo M. De Marzo; Elizabeth A. Platz; Siobhan Sutcliffe. 2021. "Why Do Epidemiologic Studies Find an Inverse Association Between Intraprostatic Inflammation and Prostate Cancer: A Possible Role for Colliding Bias?" Cancer Epidemiology Biomarkers & Prevention 30, no. 2: 255-259.
Background Black women living in southern states have the highest breast cancer mortality rate in the United States. The prognosis of de novo metastatic breast cancer is poor. Given these mortality rates, we are the first to link nationally representative data on breast cancer mortality hot spots (counties with high breast cancer mortality rates) with cancer mortality data in the United States and investigate the association of geographic breast cancer mortality hot spots with de novo metastatic breast cancer mortality among Black women. Methods We identified 7292 Black women diagnosed with de novo metastatic breast cancer in Surveillance, Epidemiology, and End Results (SEER). The county-level characteristics were obtained from 2014 County Health Rankings and linked to SEER. We used Cox proportional hazards models to calculate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for mortality between hot spot and non–hot spot counties. Results Among 7292 patients, 393 (5.4%) resided in breast cancer mortality hot spots. Women residing in hot spots had similar risks of breast cancer–specific mortality (aHR = 0.99, 95% CI = 0.85 to 1.15) and all-cause mortality (aHR = 0.97, 95% CI = 0.84 to 1.11) as women in non–hot spots after adjusting for individual and tumor-level factors and treatments. Additional adjustment for county-level characteristics did not impact mortality. Conclusion Living in a breast cancer mortality hot spot was not associated with de novo metastatic breast cancer mortality among Black women. Future research should begin to examine variation in both individual and population-level determinants, as well as in molecular and genetic determinants that underlie the aggressive nature of de novo metastatic breast cancer.
Yunan Han; Marvin Langston; Lindsay Fuzzell; Saira Khan; Marquita W Lewis-Thames; Graham A Colditz; Justin Xavier Moore. Breast Cancer Mortality Hot Spots Among Black Women With de Novo Metastatic Breast Cancer. JNCI Cancer Spectrum 2020, 5, pkaa086 .
AMA StyleYunan Han, Marvin Langston, Lindsay Fuzzell, Saira Khan, Marquita W Lewis-Thames, Graham A Colditz, Justin Xavier Moore. Breast Cancer Mortality Hot Spots Among Black Women With de Novo Metastatic Breast Cancer. JNCI Cancer Spectrum. 2020; 5 (1):pkaa086.
Chicago/Turabian StyleYunan Han; Marvin Langston; Lindsay Fuzzell; Saira Khan; Marquita W Lewis-Thames; Graham A Colditz; Justin Xavier Moore. 2020. "Breast Cancer Mortality Hot Spots Among Black Women With de Novo Metastatic Breast Cancer." JNCI Cancer Spectrum 5, no. 1: pkaa086.
Background: Cancer survivors face many challenges including coordinating care across multiple providers and maintaining medical records from multiple institutions. Access and utilization of online medical records could help cancer survivors manage this complexity. Here, we examined how cancer survivors differ from those without a history of cancer with regards to utilization and perception of medical records. Methods: We conducted a cross-sectional study of 3491 respondents, from the Health Information National Trends survey 5, cycle 2. The association of medical record utilization and perceptions with cancer survivorship was assessed using survey-weighted logistic regression. Results: Cancer survivors (n=593) were more likely to report that a provider maintains a computerized medical record [adjusted odds ratio (AOR)=2.05; 95% confidence (CI), 1.24–3.41] and were more likely to report confidence in medical record safeguards (AOR=1.44; 95% CI, 1.03–2.03). However, cancer survivors were no more likely to access online medical records than those without a history of cancer (AOR=1.13; 95% CI, 0.69–1.86). Cancer survivors were no more likely to report privacy concerns as a reason for not accessing online medical records, however, survivors were more likely to report a preference for speaking directly with a provider as a reason for not accessing online medical records (AOR=2.24; 95% CI, 0.99–5.05). Conclusions: Although cancer survivors are more likely to trust medical record safe guards and do not express increased concerns about online medical record privacy, a preference to speak directly with provider is a barrier of use.
Saira Khan; Marquita W. Lewis-Thames; Yunan Han; Lindsay Fuzzell; Marvin Langston; Justin X. Moore. A Comparative Analysis of Online Medical Record Utilization and Perception by Cancer Survivorship. Medical Care 2020, 58, 1 .
AMA StyleSaira Khan, Marquita W. Lewis-Thames, Yunan Han, Lindsay Fuzzell, Marvin Langston, Justin X. Moore. A Comparative Analysis of Online Medical Record Utilization and Perception by Cancer Survivorship. Medical Care. 2020; 58 (12):1.
Chicago/Turabian StyleSaira Khan; Marquita W. Lewis-Thames; Yunan Han; Lindsay Fuzzell; Marvin Langston; Justin X. Moore. 2020. "A Comparative Analysis of Online Medical Record Utilization and Perception by Cancer Survivorship." Medical Care 58, no. 12: 1.
Objectives: Novel Coronavirus (COVID‐19) is a global pandemic currently spreading rapidly across the United States. We provide a comprehensive look at COVID‐19 epidemiology across the state of Georgia, which includes vast rural communities that may be disproportionately impacted by the spread of this infectious disease. Methods: All 159 Georgia counties were included in this study. We examined the geographic variation of COVID‐19 in Georgia from March 3 through April 24, 2020 by extracting data on incidence and mortality from various national and state datasets. We contrasted county‐level mortality rates per 100,000 population (MRs) by county‐level factors. Results: Metropolitan Atlanta had the overall highest number of confirmed cases, however, the southwestern rural parts of Georgia, surrounding the city of Albany, had the highest bi‐weekly increases in incidence rate. Among counties with greater than 10 cases, MRs were highest in the rural counties of Randolph (233.2), Terrell (182.5), Early (136.3), and Dougherty (114.2). Counties with the highest MRs (22.5 – 2332 per 100,000) had a higher proportion of: non‐Hispanic Blacks residents, adults aged 60+, adults earning less than $20,000 annually, and residents living in rural communities when compared to counties with lower MRs. These counties also had a lower proportion of the population with a college education, lower number of ICU beds per 100,000 population, and lower number of primary care physicians per 10,000 population. Conclusions: While urban centers in Georgia account for the bulk of COVID‐19 cases, high mortality rates and low critical care capacity in rural Georgia are also of critical concern. This article is protected by copyright. All rights reserved
Justin Xavier Moore; Marvin Langston; Varghese George; Steven S. Coughlin. Epidemiology of the 2020 pandemic of COVID‐19 in the state of Georgia: Inadequate critical care resources and impact after 7 weeks of community spread. Journal of the American College of Emergency Physicians Open 2020, 1, 527 -532.
AMA StyleJustin Xavier Moore, Marvin Langston, Varghese George, Steven S. Coughlin. Epidemiology of the 2020 pandemic of COVID‐19 in the state of Georgia: Inadequate critical care resources and impact after 7 weeks of community spread. Journal of the American College of Emergency Physicians Open. 2020; 1 (4):527-532.
Chicago/Turabian StyleJustin Xavier Moore; Marvin Langston; Varghese George; Steven S. Coughlin. 2020. "Epidemiology of the 2020 pandemic of COVID‐19 in the state of Georgia: Inadequate critical care resources and impact after 7 weeks of community spread." Journal of the American College of Emergency Physicians Open 1, no. 4: 527-532.
Background To investigate whether meteorological factors (temperature, barometric pressure, relative humidity, ultraviolet index [UVI], and seasons) trigger flares in male and female urologic chronic pelvic pain patients. Methods We assessed flare status every 2 weeks in our case‐crossover study of flare triggers in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain 1‐year longitudinal study. Flare symptoms, flare start date, and exposures in the 3 days preceding a flare or the date of questionnaire completion were assessed for the first three flares and at three randomly selected nonflare times. We linked these data to daily temperature, barometric pressure, relative humidity, and UVI values by participants’ first 3 zip code digits. Values in the 3 days before and the day of a flare, as well as changes in these values, were compared to nonflare values by conditional logistic regression. Differences in flare rates by astronomical and growing seasons were investigated by Poisson regression in the full study population. Results A total of 574 flare and 792 nonflare assessments (290 participants) were included in the case‐crossover analysis, and 966 flare and 5389 nonflare (409 participants) were included in the full study analysis. Overall, no statistically significant associations were observed for daily weather, no patterns of associations were observed for weather changes, and no differences in flare rates were observed by season. Conclusions We found minimal evidence to suggest that weather triggers flares, although we cannot rule out the possibility that a small subset of patients is susceptible.
Jieni Li; Tiange Yu; Irum Javed; Chaitanya Siddagunta; Ratna Pakpahan; Marvin Langston; Leslie K. Dennis; Darrel M. Kingfield; David J. Moore; Gerald L. Andriole; H. Henry Lai; Graham Colditz; Siobhan Sutcliffe; for the MAPP Research Network. Does weather trigger urologic chronic pelvic pain syndrome flares? A case‐crossover analysis in the multidisciplinary approach to the study of the chronic pelvic pain research network. Neurourology and Urodynamics 2020, 39, 1494 -1504.
AMA StyleJieni Li, Tiange Yu, Irum Javed, Chaitanya Siddagunta, Ratna Pakpahan, Marvin Langston, Leslie K. Dennis, Darrel M. Kingfield, David J. Moore, Gerald L. Andriole, H. Henry Lai, Graham Colditz, Siobhan Sutcliffe, for the MAPP Research Network. Does weather trigger urologic chronic pelvic pain syndrome flares? A case‐crossover analysis in the multidisciplinary approach to the study of the chronic pelvic pain research network. Neurourology and Urodynamics. 2020; 39 (5):1494-1504.
Chicago/Turabian StyleJieni Li; Tiange Yu; Irum Javed; Chaitanya Siddagunta; Ratna Pakpahan; Marvin Langston; Leslie K. Dennis; Darrel M. Kingfield; David J. Moore; Gerald L. Andriole; H. Henry Lai; Graham Colditz; Siobhan Sutcliffe; for the MAPP Research Network. 2020. "Does weather trigger urologic chronic pelvic pain syndrome flares? A case‐crossover analysis in the multidisciplinary approach to the study of the chronic pelvic pain research network." Neurourology and Urodynamics 39, no. 5: 1494-1504.
Adults living in rural areas, compared to their urban counterparts, are at an increased risk of using tobacco-related products and mortality due to tobacco-related diseases. The harms and benefits of e-cigarette use are mixed, and similarly obscure messaging about these harms and benefits have a critical influence on e-cigarette uptake and perceptions. However, little is known about rural-urban differences in the prevalence of adult e-cigarette daily usage. Using the Health Information National Trends Survey-Food and Drug Administration (HINTS-FDA) cycles 1 and 2, we conducted weighted logistic regressions to assess rural-urban differences in the prevalence of adult e-cigarette daily usage, perceived harm, and e-cigarette information seeking behaviors. This analysis included adults aged 18 years and older in the United States (N = 4229). Both rural and urban respondents reported a similar history of e-cigarette use. Rural respondents were significantly more likely than urban respondents to trust religious organizations and leaders and tobacco companies for information about e-cigarettes. Rural and urban respondents were equally as likely to believe e-cigarettes are addictive, perceive e-cigarette use as harmful, and believe e-cigarettes are more harmful than tobacco cigarettes. Respondents were equally as likely to look for information on e-cigarettes, the health effects of e-cigarettes, and cessation; and, to seek e-cigarette information from healthcare professionals, family and friends, and health organizations and groups. Given our findings, it will be pertinent to continue to research the potential harms of e-cigarette use and develop accurate health communication messages to avoid rural-urban disparities observed for cigarette smoking-related outcomes.
Marquita W. Lewis-Thames; Marvin Langston; Lindsay Fuzzell; Saira Khan; Justin Xavier Moore; Yunan Han. Rural-urban differences e-cigarette ever use, the perception of harm, and e-cigarette information seeking behaviors among U.S. adults in a nationally representative study. Preventive Medicine 2019, 130, 105898 -105898.
AMA StyleMarquita W. Lewis-Thames, Marvin Langston, Lindsay Fuzzell, Saira Khan, Justin Xavier Moore, Yunan Han. Rural-urban differences e-cigarette ever use, the perception of harm, and e-cigarette information seeking behaviors among U.S. adults in a nationally representative study. Preventive Medicine. 2019; 130 ():105898-105898.
Chicago/Turabian StyleMarquita W. Lewis-Thames; Marvin Langston; Lindsay Fuzzell; Saira Khan; Justin Xavier Moore; Yunan Han. 2019. "Rural-urban differences e-cigarette ever use, the perception of harm, and e-cigarette information seeking behaviors among U.S. adults in a nationally representative study." Preventive Medicine 130, no. : 105898-105898.
Tumors of the inner quadrants of the breast are associated with poorer survival than those of the upper-outer quadrant. It is unknown whether racial differences in breast cancer outcomes are modified by breast quadrant, in addition to comparisons among Asian subgroups. Using the Surveillance, Epidemiology, and End Results database, we analyzed data among women diagnosed with non-metastatic invasive breast cancer between 1990 and 2014. We performed Cox proportional hazards regression models to assess the associations of race with breast cancer-specific survival and overall survival, stratified by breast quadrants. The models were adjusted for age, year of the diagnosis, tumor size, grade, histological type, tumor laterality, lymph node, estrogen receptor, progesterone receptor, and treatments. Among 454,154 patients (73.0% White, 10.0% Black, 7.8% Asian/PI, and 9.2% Hispanic), 54.3% had tumors diagnosed in the upper-outer quadrant of the breast. Asian/PI women were more likely than White to have tumors diagnosed in the nipple/central portion of the breast and were less likely to have diagnosed in the upper-outer quadrant (P < 0.001), despite a similar distribution of breast quadrant between Black, Hispanic, and White women. Compared with White women, the multivariable-adjusted hazard ratios of breast cancer-specific mortality were 1.41 (95% CI 1.37–1.44) in Black women, 0.82 (95% CI 0.79–0.85) in Asian women, and 1.05 (95% CI 1.02–1.09) in Hispanic women. Among Asian subgroups, Japanese American women had a lower risk of breast cancer-specific mortality (HR = 0.68, 95% CI 0.62–0.74) compared with White women. Overall survival was similar to breast cancer-specific survival in each race group. The race-associated risks did not vary significantly by breast quadrants for breast cancer-specific mortality and all-cause mortality. Differences in breast cancer survival by race could not be attributed to tumor locations. Understanding the cultural, biological, and lifestyle factors that vary between White, African American, and ethnic subgroups of Asian American women may help explain these survival differences.
Yunan Han; Justin Xavier Moore; Marvin Langston; Lindsay Fuzzell; Saira Khan; Marquita W. Lewis; Graham Colditz; Ying Liu. Do breast quadrants explain racial disparities in breast cancer outcomes? Cancer Causes & Control 2019, 30, 1171 -1182.
AMA StyleYunan Han, Justin Xavier Moore, Marvin Langston, Lindsay Fuzzell, Saira Khan, Marquita W. Lewis, Graham Colditz, Ying Liu. Do breast quadrants explain racial disparities in breast cancer outcomes? Cancer Causes & Control. 2019; 30 (11):1171-1182.
Chicago/Turabian StyleYunan Han; Justin Xavier Moore; Marvin Langston; Lindsay Fuzzell; Saira Khan; Marquita W. Lewis; Graham Colditz; Ying Liu. 2019. "Do breast quadrants explain racial disparities in breast cancer outcomes?" Cancer Causes & Control 30, no. 11: 1171-1182.
Background: The protist Trichomonas vaginalis causes a common, sexually transmitted infection and has been proposed to contribute to the development of chronic prostate conditions, including benign prostatic hyperplasia and prostate cancer. However, few studies have investigated the extent to which it involves the prostate in the current antimicrobial era. We addressed this question by investigating the relation between T. vaginalis antibody serostatus and serum prostate‐specific antigen (PSA) concentration, a marker of prostate infection, inflammation, and/or cell damage, in young, male, US military members. Methods: We measured T. vaginalis serum IgG antibodies and serum total PSA concentration in a random sample of 732 young, male US active duty military members. Associations between T. vaginalis serostatus and PSA were investigated by linear regression. Results: Of the 732 participants, 341 (46.6%) had a low T. vaginalis seropositive score and 198 (27.0%) had a high score, with the remainder seronegative. No significant differences were observed in the distribution of PSA by T. vaginalis serostatus. However, slightly greater, nonsignificant differences were observed when men with high T. vaginalis seropositive scores were compared with seronegative men, and when higher PSA concentrations were examined (≥0.70 ng/mL). Specifically, 42.5% of men with high seropositive scores had a PSA concentration greater than or equal to 0.70 ng/mL compared with 33.2% of seronegative men (adjusted P = .125). Conclusions: Overall, our findings do not provide strong support for prostate involvement during T. vaginalis infection, although our suggestive positive findings for higher PSA concentrations do not rule out this possibility entirely. These suggestive findings may be relevant for prostate condition development because higher early‐ to mid‐life PSA concentrations have been found to predict greater prostate cancer risk later in life.
Marvin E. Langston; Ankita Bhalla; John F. Alderete; Remington L. Nevin; Ratna Pakpahan; Johannah Hansen; Debra Elliott; Angelo M. De Marzo; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Jonathan M. Zenilman; Elizabeth A. Platz; Siobhan Sutcliffe. Trichomonas vaginalis infection and prostate‐specific antigen concentration: Insights into prostate involvement and prostate disease risk. The Prostate 2019, 79, 1622 -1628.
AMA StyleMarvin E. Langston, Ankita Bhalla, John F. Alderete, Remington L. Nevin, Ratna Pakpahan, Johannah Hansen, Debra Elliott, Angelo M. De Marzo, Charlotte A. Gaydos, William B. Isaacs, William G. Nelson, Lori J. Sokoll, Jonathan M. Zenilman, Elizabeth A. Platz, Siobhan Sutcliffe. Trichomonas vaginalis infection and prostate‐specific antigen concentration: Insights into prostate involvement and prostate disease risk. The Prostate. 2019; 79 (14):1622-1628.
Chicago/Turabian StyleMarvin E. Langston; Ankita Bhalla; John F. Alderete; Remington L. Nevin; Ratna Pakpahan; Johannah Hansen; Debra Elliott; Angelo M. De Marzo; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Jonathan M. Zenilman; Elizabeth A. Platz; Siobhan Sutcliffe. 2019. "Trichomonas vaginalis infection and prostate‐specific antigen concentration: Insights into prostate involvement and prostate disease risk." The Prostate 79, no. 14: 1622-1628.
Previous meta-analyses have estimated summary positive associations between clinical prostatitis and prostate cancer. However, none have accounted for detection bias, the possibility for increased prostate cancer screening and detection in men with clinical prostatitis, in their pooled estimates. We searched for studies that investigated the relation between clinical prostatitis and prostate cancer through November 2018. Random effects meta-analysis was used to calculate summary odds ratios (OR) among all studies and in strata defined by methods used to reduce detection bias.Results: Although an increased odds of prostate cancer was seen among men with a history of clinical prostatitis in all 38 eligible studies combined [OR, 2.05; 95% confidence interval (CI), 1.64-2.57], this estimate attenuated to null among studies that performed the most rigorous analyses to limit detection bias (OR, 1.16; 95% CI, 0.77-1.74). Our findings indicate that previously reported positive associations between clinical prostatitis and prostate cancer are likely due to detection bias. Studies using rigorous detection bias methods are warranted to replicate these findings, as well as to examine the possible relation between prostate inflammation and prostate cancer directly, rather than indirectly through the diagnosis of "prostatitis," which includes a large proportion of men without evidence of prostate inflammation.
Marvin E. Langston; Mara Horn; Saira Khan; Ratna Pakpahan; Michelle Doering; Leslie K. Dennis; Siobhan Sutcliffe. A Systematic Review and Meta-analysis of Associations between Clinical Prostatitis and Prostate Cancer: New Estimates Accounting for Detection Bias. Cancer Epidemiology Biomarkers & Prevention 2019, 28, 1594 -1603.
AMA StyleMarvin E. Langston, Mara Horn, Saira Khan, Ratna Pakpahan, Michelle Doering, Leslie K. Dennis, Siobhan Sutcliffe. A Systematic Review and Meta-analysis of Associations between Clinical Prostatitis and Prostate Cancer: New Estimates Accounting for Detection Bias. Cancer Epidemiology Biomarkers & Prevention. 2019; 28 (10):1594-1603.
Chicago/Turabian StyleMarvin E. Langston; Mara Horn; Saira Khan; Ratna Pakpahan; Michelle Doering; Leslie K. Dennis; Siobhan Sutcliffe. 2019. "A Systematic Review and Meta-analysis of Associations between Clinical Prostatitis and Prostate Cancer: New Estimates Accounting for Detection Bias." Cancer Epidemiology Biomarkers & Prevention 28, no. 10: 1594-1603.
Purpose: A lack of national data makes it difficult to estimate, but LGB adults appear to have a higher risk of cancer. Although limited research exists to explain the disparity, we aimed to explore potential differences in access to and utilization of health information and in cancer-related beliefs and behaviors. Methods: We used data from the Health Information National Trends Survey 5, Cycle 1 conducted from January 25 through May 5, 2017. Using survey-weighted logistic regression, we explored potential differences in health information-seeking behavior, trusted sources of health care information, engagement with the health care system, awareness of cancer risk factors, cancer fatalism, cancer-related health behaviors, and historical cancer screening between 117 LGB and 2857 heterosexual respondents. Results: LGB respondents were more likely to report looking for information about health or medical topics than heterosexual respondents (adjusted odds ratio [aOR]: 3.12; confidence interval [95% CI]: 1.07-9.06), but less likely to seek health information first from a doctor (aOR: 0.17; 95% CI: 0.06-0.50) after adjusting for age, race, and sex. LGB persons were less likely to report that they trust receiving health or medical information from friends and family and more likely to be worried about getting cancer (aOR: 2.30; 95% CI: 1.04-5.05). Conclusions: Our findings indicate a growing need for the production of tailored cancer prevention and control materials for members of sexual minority groups. More work is needed to understand barriers that LGB populations face in accessing this health information and building informative social support networks.
Marvin E. Langston; Lindsay Fuzzell; Marquita W. Lewis-Thames; Saira Khan; Justin X. Moore. Disparities in Health Information-Seeking Behaviors and Fatalistic Views of Cancer by Sexual Orientation Identity: A Nationally Representative Study of Adults in the United States. LGBT Health 2019, 6, 192 -201.
AMA StyleMarvin E. Langston, Lindsay Fuzzell, Marquita W. Lewis-Thames, Saira Khan, Justin X. Moore. Disparities in Health Information-Seeking Behaviors and Fatalistic Views of Cancer by Sexual Orientation Identity: A Nationally Representative Study of Adults in the United States. LGBT Health. 2019; 6 (4):192-201.
Chicago/Turabian StyleMarvin E. Langston; Lindsay Fuzzell; Marquita W. Lewis-Thames; Saira Khan; Justin X. Moore. 2019. "Disparities in Health Information-Seeking Behaviors and Fatalistic Views of Cancer by Sexual Orientation Identity: A Nationally Representative Study of Adults in the United States." LGBT Health 6, no. 4: 192-201.
The goals of this study were to identify geographic and racial/ethnic variation in breast cancer mortality, and evaluate whether observed geographic differences are explained by county-level characteristics. We analyzed data on breast cancer deaths among women in 3,108 contiguous United States (US) counties from years 2000 through 2015. We applied novel geospatial methods and identified hot spot counties based on breast cancer mortality rates. We assessed differences in county-level characteristics between hot spot and other counties using Wilcoxon rank-sum test and Spearman correlation, and stratified all analysis by race/ethnicity. Among all women, 80 of 3,108 (2.57%) contiguous US counties were deemed hot spots for breast cancer mortality with the majority located in the southern region of the US (72.50%, p value < 0.001). In race/ethnicity-specific analyses, 119 (3.83%) hot spot counties were identified for NH-Black women, with the majority being located in southern states (98.32%, p value < 0.001). Among Hispanic women, there were 83 (2.67%) hot spot counties and the majority was located in the southwest region of the US (southern = 61.45%, western = 33.73%, p value < 0.001). We did not observe definitive geographic patterns in breast cancer mortality for NH-White women. Hot spot counties were more likely to have residents with lower education, lower household income, higher unemployment rates, higher uninsured population, and higher proportion indicating cost as a barrier to medical care. We observed geographic and racial/ethnic disparities in breast cancer mortality: NH-Black and Hispanic breast cancer deaths were more concentrated in southern, lower SES counties.
Justin Xavier Moore; Kendra J. Royston; Marvin E. Langston; Russell Griffin; Bertha Hidalgo; Henry E. Wang; Graham Colditz; Tomi Akinyemiju. Mapping hot spots of breast cancer mortality in the United States: place matters for Blacks and Hispanics. Cancer Causes & Control 2018, 29, 737 -750.
AMA StyleJustin Xavier Moore, Kendra J. Royston, Marvin E. Langston, Russell Griffin, Bertha Hidalgo, Henry E. Wang, Graham Colditz, Tomi Akinyemiju. Mapping hot spots of breast cancer mortality in the United States: place matters for Blacks and Hispanics. Cancer Causes & Control. 2018; 29 (8):737-750.
Chicago/Turabian StyleJustin Xavier Moore; Kendra J. Royston; Marvin E. Langston; Russell Griffin; Bertha Hidalgo; Henry E. Wang; Graham Colditz; Tomi Akinyemiju. 2018. "Mapping hot spots of breast cancer mortality in the United States: place matters for Blacks and Hispanics." Cancer Causes & Control 29, no. 8: 737-750.
Background To extend our previous observation of a short‐term rise in prostate‐specific antigen (PSA) concentration, a marker of prostate inflammation and cell damage, during and immediately following sexually transmitted and systemic infections, we examined the longer‐term influence of these infections, both individually and cumulatively, on PSA over a mean of 10 years of follow‐up in young active duty U.S. servicemen. Methods We measured PSA in serum specimens collected in 1995‐7 (baseline) and 2004‐6 (follow‐up) from 265 men diagnosed with chlamydia (CT), 72 with gonorrhea (GC), 37 with non‐chlamydial, non‐gonococcal urethritis (NCNGU), 58 with infectious mononucleosis (IM), 91 with other systemic or non‐genitourinary infections such as varicella; and 125‐258 men with no infectious disease diagnoses in their medical record during follow‐up (controls). We examined the influence of these infections on PSA change between baseline and follow‐up. Results The proportion of men with any increase in PSA (>0 ng/mL) over the 10‐year average follow‐up was significantly higher in men with histories of sexually transmitted infections (CT, GC, and NCNGU; 67.7% vs 60.8%, P = 0.043), systemic infections (66.7% vs 54.4%, P = 0.047), or any infections (all cases combined; 68.5% vs 54.4%, P = 0.003) in their military medical record compared to controls. Conclusions While PSA has been previously shown to rise during acute infection, these findings demonstrate that PSA remains elevated over a longer period. Additionally, the overall infection burden, rather than solely genitourinary‐specific infection burden, contributed to these long‐term changes, possibly implying a role for the cumulative burden of infections in prostate cancer risk.
Marvin E. Langston; Ratna Pakpahan; Remington L. Nevin; Angelo M. De Marzo; Debra J. Elliott; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Jonathan M. Zenilman; Elizabeth A. Platz; Siobhan Sutcliffe. Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up. The Prostate 2018, 78, 1024 -1034.
AMA StyleMarvin E. Langston, Ratna Pakpahan, Remington L. Nevin, Angelo M. De Marzo, Debra J. Elliott, Charlotte A. Gaydos, William B. Isaacs, William G. Nelson, Lori J. Sokoll, Jonathan M. Zenilman, Elizabeth A. Platz, Siobhan Sutcliffe. Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up. The Prostate. 2018; 78 (13):1024-1034.
Chicago/Turabian StyleMarvin E. Langston; Ratna Pakpahan; Remington L. Nevin; Angelo M. De Marzo; Debra J. Elliott; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Jonathan M. Zenilman; Elizabeth A. Platz; Siobhan Sutcliffe. 2018. "Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up." The Prostate 78, no. 13: 1024-1034.
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Saira Khan; Veronica Hicks; Danielle Rancilio; Marvin Langston; Katina Richardson; Bettina F. Drake. Predictors of Follow-Up Visits Post Radical Prostatectomy. American Journal of Men's Health 2018, 12, 760 -765.
AMA StyleSaira Khan, Veronica Hicks, Danielle Rancilio, Marvin Langston, Katina Richardson, Bettina F. Drake. Predictors of Follow-Up Visits Post Radical Prostatectomy. American Journal of Men's Health. 2018; 12 (4):760-765.
Chicago/Turabian StyleSaira Khan; Veronica Hicks; Danielle Rancilio; Marvin Langston; Katina Richardson; Bettina F. Drake. 2018. "Predictors of Follow-Up Visits Post Radical Prostatectomy." American Journal of Men's Health 12, no. 4: 760-765.
Ultraviolet radiation (UVR) has been associated with various health outcomes, including skin cancers, vitamin D insufficiency, and multiple sclerosis. Measurement of UVR has been difficult, traditionally relying on subject recall. We investigated trends in satellite-derived UVB from 1978 to 2014 within the continental United States (US) to inform UVR exposure assessment and determine the potential magnitude of misclassification bias created by ignoring these trends. Monthly UVB data remotely sensed from various NASA satellites were used to investigate changes over time in the United States using linear regression with a harmonic function. Linear regression models for local geographic areas were used to make inferences across the entire study area using a global field significance test. Temporal trends were investigated across all years and separately for each satellite type due to documented differences in UVB estimation. UVB increased from 1978 to 2014 in 48% of local tests. The largest UVB increase was found in Western Nevada (0.145 kJ/m2 per five-year increment), a total 30-year increase of 0.87 kJ/m2. This largest change only represented 17% of total ambient exposure for an average January and 2% of an average July in Western Nevada. The observed trends represent cumulative UVB changes of less than a month, which are not relevant when attempting to estimate human exposure. The observation of small trends should be interpreted with caution due to measurement of satellite parameter inputs (ozone and climatological factors) that may impact derived satellite UVR nearly 20% compared to ground level sources. If the observed trends hold, satellite-derived UVB data may reasonably estimate ambient UVB exposures even for outcomes with long latency phases that predate the satellite record.
Marvin Langston; Leslie Dennis; Charles Lynch; Denise Roe; Heidi Brown. Temporal Trends in Satellite-Derived Erythemal UVB and Implications for Ambient Sun Exposure Assessment. International Journal of Environmental Research and Public Health 2017, 14, 176 .
AMA StyleMarvin Langston, Leslie Dennis, Charles Lynch, Denise Roe, Heidi Brown. Temporal Trends in Satellite-Derived Erythemal UVB and Implications for Ambient Sun Exposure Assessment. International Journal of Environmental Research and Public Health. 2017; 14 (2):176.
Chicago/Turabian StyleMarvin Langston; Leslie Dennis; Charles Lynch; Denise Roe; Heidi Brown. 2017. "Temporal Trends in Satellite-Derived Erythemal UVB and Implications for Ambient Sun Exposure Assessment." International Journal of Environmental Research and Public Health 14, no. 2: 176.
Although Epstein‐Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. One possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early adulthood when infection is more likely to manifest as infectious mononucleosis (IM). We sought to determine the influence of young adult‐onset IM on the prostate by measuring prostate‐specific antigen (PSA) as a marker of prostate inflammation/damage among U.S. military members. We defined IM cases as men diagnosed with IM from 1998 to 2003 (n = 55) and controls as men without an IM diagnosis (n = 255). We selected two archived serum specimens for each participant, the first collected after diagnosis for cases and one randomly selected from 1998 to 2003 for controls (index), as well as the preceding specimen (preindex). PSA was measured in each specimen. To explore the specificity of our findings for prostate as opposed to systemic inflammation, we performed a post hoc comparison of other infectious disease cases without genitourinary involvement (n = 90) and controls (n = 220). We found that IM cases were more likely to have a large PSA rise than controls (≥20 ng/mL: 19.7% versus 8.8%, p = 0.027; ≥40% rise: 25.7% versus 9.4%, p = 0.0021), as were other infectious disease cases (25.7% versus 14.0%, p = 0.020; 27.7% versus 18.0%, p = 0.092). These findings suggest that, in addition to rising because of prostate infection, PSA may also rise because of systemic inflammation, which could have implications for PSA interpretation in older men.
Siobhan Sutcliffe; Remington Nevin; Ratna Pakpahan; Debra J. Elliott; Marvin Langston; Angelo M. De Marzo; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Patrick C. Walsh; Jonathan M. Zenilman; Steven B. Cersovsky; Elizabeth A. Platz. Infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection. International Journal of Cancer 2015, 138, 2221 -2230.
AMA StyleSiobhan Sutcliffe, Remington Nevin, Ratna Pakpahan, Debra J. Elliott, Marvin Langston, Angelo M. De Marzo, Charlotte A. Gaydos, William B. Isaacs, William G. Nelson, Lori J. Sokoll, Patrick C. Walsh, Jonathan M. Zenilman, Steven B. Cersovsky, Elizabeth A. Platz. Infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection. International Journal of Cancer. 2015; 138 (9):2221-2230.
Chicago/Turabian StyleSiobhan Sutcliffe; Remington Nevin; Ratna Pakpahan; Debra J. Elliott; Marvin Langston; Angelo M. De Marzo; Charlotte A. Gaydos; William B. Isaacs; William G. Nelson; Lori J. Sokoll; Patrick C. Walsh; Jonathan M. Zenilman; Steven B. Cersovsky; Elizabeth A. Platz. 2015. "Infectious mononucleosis, other infections and prostate-specific antigen concentration as a marker of prostate involvement during infection." International Journal of Cancer 138, no. 9: 2221-2230.
Regular physical activity can help prevent chronic diseases, yet only half of US adults meet national physical activity guidelines. One barrier to physical activity is a lack of safe places to be active, such as bike paths and sidewalks. Complete Streets, streets designed to enable safe access for all users, can help provide safe places for activity. This community case study presents results from interviews with residents and policymakers of Topeka, Kansas, who played an integral role in the passage of a Complete Streets resolution in 2009. It describes community engagement processes used to include stakeholders, assess existing roads and sidewalks, and communicate with the public and decision-makers. Key informant interviews were conducted with city council members and members of Heartland Healthy Neighborhoods in Topeka to learn how they introduced a Complete Streets resolution and the steps they took to ensure its successful passage in the City Council. Interviews were recorded, transcribed, and analyzed by using focused-coding qualitative analysis. Results included lessons learned from the process of passing the Complete Streets resolution and advice from participants for other communities interested in creating Complete Streets in their communities. Lessons learned can apply to other communities pursuing Complete Streets. Examples include clearly defining Complete Streets; educating the public, advocates, and decision-makers about Complete Streets and how this program enhances a community; building a strong and diverse network of supporters; and using stories and examples from other communities with Complete Streets to build a convincing case.
Elizabeth A. Dodson; Marvin Langston; Lauren C. Cardick; Nancy Johnson; Paula Clayton; Ross C. Brownson. “Everyone Should Be Able to Choose How They Get Around”: How Topeka, Kansas, Passed a Complete Streets Resolution. Preventing Chronic Disease 2014, 11, E25 .
AMA StyleElizabeth A. Dodson, Marvin Langston, Lauren C. Cardick, Nancy Johnson, Paula Clayton, Ross C. Brownson. “Everyone Should Be Able to Choose How They Get Around”: How Topeka, Kansas, Passed a Complete Streets Resolution. Preventing Chronic Disease. 2014; 11 ():E25.
Chicago/Turabian StyleElizabeth A. Dodson; Marvin Langston; Lauren C. Cardick; Nancy Johnson; Paula Clayton; Ross C. Brownson. 2014. "“Everyone Should Be Able to Choose How They Get Around”: How Topeka, Kansas, Passed a Complete Streets Resolution." Preventing Chronic Disease 11, no. : E25.
Guang-Hui Dong; Zhengmin (Min) Qian; Jing Wang; Weiqing Chen; Wenjun Ma; Edwin Trevathan; Pamela Xaverius; Richard DeClue; Andrew Wiese; Marvin Langston; Miao-Miao Liu; Da Wang; Wan-Hui Ren. Associations between ambient air pollution and prevalence of stroke and cardiovascular diseases in 33 Chinese communities. Atmospheric Environment 2013, 77, 968 -973.
AMA StyleGuang-Hui Dong, Zhengmin (Min) Qian, Jing Wang, Weiqing Chen, Wenjun Ma, Edwin Trevathan, Pamela Xaverius, Richard DeClue, Andrew Wiese, Marvin Langston, Miao-Miao Liu, Da Wang, Wan-Hui Ren. Associations between ambient air pollution and prevalence of stroke and cardiovascular diseases in 33 Chinese communities. Atmospheric Environment. 2013; 77 ():968-973.
Chicago/Turabian StyleGuang-Hui Dong; Zhengmin (Min) Qian; Jing Wang; Weiqing Chen; Wenjun Ma; Edwin Trevathan; Pamela Xaverius; Richard DeClue; Andrew Wiese; Marvin Langston; Miao-Miao Liu; Da Wang; Wan-Hui Ren. 2013. "Associations between ambient air pollution and prevalence of stroke and cardiovascular diseases in 33 Chinese communities." Atmospheric Environment 77, no. : 968-973.
Elizabeth A. Baker; Ellen Barnidge; Marvin Langston; Mario Schootman; Freda Motton; Frank Rose. Leadership and Job Readiness: Addressing Social Determinants of Health Among Ruralafrican American Men. International Journal of Men's Health 2013, 12, 245 -259.
AMA StyleElizabeth A. Baker, Ellen Barnidge, Marvin Langston, Mario Schootman, Freda Motton, Frank Rose. Leadership and Job Readiness: Addressing Social Determinants of Health Among Ruralafrican American Men. International Journal of Men's Health. 2013; 12 (3):245-259.
Chicago/Turabian StyleElizabeth A. Baker; Ellen Barnidge; Marvin Langston; Mario Schootman; Freda Motton; Frank Rose. 2013. "Leadership and Job Readiness: Addressing Social Determinants of Health Among Ruralafrican American Men." International Journal of Men's Health 12, no. 3: 245-259.