The Alxa Block is located in the middle part of the Central Asian orogenic belt, which is the coupling belt of the North China, Tarim, and Kazakhstan Plates. The east–west-trending deep faults control stratigraphic distribution and magmatic activity in the region. To detect the EW-trending ore-controlling deep structures, a 440 km NS section of magnetotelluric sounding was conducted from Minle to Ejinaqi. The phase tensor and electrical principal axis were analyzed based on the measured data to build the exploration model. The electrical structure model along the section was obtained using nonlinear conjugate gradient (NLCG) 2D inversion. Combined with the geological, geophysical, and deposit distribution characteristics in the area, the comprehensive study of magnetotelluric sounding profile shows that the resistivity presents as zoned along the profile. The Engelwusu ophiolite mélange belt is stacked in clumps with high and low resistivity, indicating that the northern margin of the Engelwusu Belt subducts below the high-resistivity zone, representing the passive continental margin. The southern end of the Engelwusu ophiolite belt is primarily the prospecting potential area for copper–gold deposits, whereas the northern end of the Engelwusu ophiolite belt corresponds to copper polymetallic deposits.