Exercise physiologists and coaches prescribe heart rate zones (between 65 and 80% of maximal heart rate, HR_max) during a marathon because it supposedly represents specific metabolic zones and the percentage of $\dot{V}$O_2max below the lactate threshold. The present study tested the hypothesis that the heart rate does not reflect the oxygen uptake of recreational runners during a marathon and that this dissociation would be more pronounced in the lower performers’ group (>4 h). While wearing a portable gas exchange system, ten male endurance runners performed an incremental test on the road to determine $\dot{V}$O_2max, HR_max, and anaerobic threshold. Two weeks later, the same subjects ran a marathon with the same device for measuring the gas exchanges and HR continuously. The %HR_max remained stable after the 5th km (between 88% and 91%, p = 0.27), which was not significantly different from the %HR_max at the ventilatory threshold (89 ± 4% vs. 93 ± 6%, p = 0.12). However, the %$\dot{V}$O_2max and percentage of the speed associated with $\dot{V}$O_2max decreased during the marathon (81 ± 5 to 74 ± 5 %$\dot{V}$O_2max and 72 ± 9 to 58 ± 14 %v$\dot{V}$O_2max, p < 0.0001). Hence, the ratio between %HR_max and %$\dot{V}$O_2max increased significantly between the 5th and the 42nd km (from 1.01 to 1.19, p = < 0.001). In conclusion, pacing during a marathon according to heart rate zones is not recommended. Rather, learning about the relationship between running sensations during training and racing using RPE is optimal.

Although the marathon race has been democratized, it remains complex due to the famous “hitting the wall” phenomenon after the 25th km. To characterize this “wall” from a physiological and Rate of Perceived Exertion (RPE) perspective in recreational marathon runners, we report first continuous breath-by-breath gas exchange measurements during an actual marathon race. In order to test the hypothesis that RPE could be a candidate for controlling the marathon pace, this study examined the relationship between RPE and the physiological variables time course throughout a marathon. Only the respiratory frequency and heart rate increased progressively during the race in all the runners, while the oxygen uptake and ventilatory rate followed different kinetics according the individuals. However, the indexation of the physiological parameters and speed by RPE showed the same decreased tendency for all the runners. In conclusion, these results suggest that running a marathon must be self-paced with the RPE.