Pathogenesis and Regulation of Cognitive Impairment in Diseased Brains. Specifically, I am interested in pathogenesis and regulation of cognitive impairment in the diseased brains, such as Alzheimer's disease and schizophrenia. I successfully administered multiple grants and published papers. By clarifying the neurobiological mechanism of learning and memory, this paper provides a theoretical basis and feasible scheme for the regulation of neural circuit and target specific drug intervention of cognitive impairment in related diseases.