Background: Understanding the impact of altitude on muscle damage and oxidative stress is essential for optimizing training and recovery strategies for athletes exposed to high-altitude conditions. Therefore, this study aimed to investigate the effects of acute exercise at different altitudes on oxidative stress and muscle damage. Methods: A total of twelve elite long-distance runners (mean age: 20.3 ± 1.5 years) from different branches participated in the study. The exercise protocol was the Bruce submaximal treadmill exercise test, which was conducted under three simulated hypoxic conditions (at 1,700 m, 2,450 m, and 3,200 m) and one normoxic condition (sea level). All measurements took place at the same time of the day. After the exercise protocol, 5 ml venous blood samples were taken from the participants, while heart rate and oxygen saturation were monitored at the 3rd, 6th, 9th, and 12th minutes during the exercise. Results: Significant altitude-dependent variations were observed in oxidative stress markers, with total oxidant status (TOS) (p = 0.017) and malondialdehyde (MDA) (p < 0.001) levels increasing at higher altitudes, while total antioxidant status (TAS) (p < 0.001) exhibited an elevation and oxidative stress index (OSI) (p < 0.001) demonstrated a decline as altitude increased. However, no significant difference was found in creatine kinase (CK, p = 0.059) levels. Additionally, there were significant differences in the oxygen saturation measurement taken at the 3rd (p < 0.001), 6th (p < 0.001), 9th (p < 0.001), and 12th (p < 0.001), minutes following the exercise session. There was no difference in the pulse measurement taken at the 3rd and 12th minutes, but a difference was observed at the 6th and 9th minutes post-exercise (p < 0.01). Conclusions: In conclusion, the study determined that endurance exercises performed under simulated normobaric hypoxia at different altitudes increased TAS and reduced OSI in elite long-distance runners. The increase in TAS and the reduction in OSI were more pronounced at higher altitudes, particularly at 2,450 m and 3,200 m, compared to sea level. These findings highlight the need for altitude-specific training and recovery strategies to minimize oxidative stress and muscle damage in athletes.

Core Antrenmanının Sürat Parametreleri Üzerine Etkisi (Bir Meta-Analiz Çalışması) İdris KAYANTAŞ Mehmet SÖYLER Core Egzersiz Kavramı ve Anatomisi Yıldırım Gökhan GENCER Covid-19 Salgınının Beş Büyük Avrupa Ligine Olan Ekonomik Etkilerinin İncelenmesi Atakan AKSU Gürkan TANOĞLU Tuba Fatma KARADAĞ Covid-19 Salgınının Spor Organizasyonlarına Etkisi ve Ekonomik Zararları Gülsüm YILMAZ Enes BELTEKİN Egzersiz ve Bazı Hormon Parametreleri Arasındaki İlişki Nilüfer BULUT Güreş Sporunun Fiziksel ve Fizyolojik Özellikleri Hüseyin EROĞLU Spor Bilimleri Fakültesi Öğrencilerinde Yaşam Tatmini ve Boş Zaman Yönetimleri Barış KARAOĞLU Mali Tablolar Bakımından Spor Kulüpleri Yasasının Gerekliliği (Dört Büyükler Örneği) Oğuzhan EROĞLU Tuba Fatma KARADAĞ Pandemide (Covid-19) Egzersiz ve Beslenme Ali TÜRKER Kahramanmaraş Kültüründe Yüzük Oyunu Abdullah DOĞAN Genç Kadın Futbolcularda Şuttaki Top Hızı: Kuvvet, Güç ve Antropometre Yıldırım Gökhan GENCER Mücahit SARİKAYA Fatih ERİŞ Emre Can IĞDIR Salih ÖNER