Dr. Nevena Tomasevic
Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, Serbia
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Academic Career Length
9Years (2018-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 March 2018 in International Journal of Antimicrobial Agents
Journal Article
BABiljana Arsic
Biljana ArsicJBJill Barber
Jill Barber
AČAna Čikoš
Ana Čikoš
MMMilan Mladenovic
Milan Mladenovic
NSNevena Stankovic
Nevena StankovicPNPredrag Novak
Predrag Novak
Journal Article
MMMilan Mladenovic
Milan MladenovicBABiljana Arsic
Biljana ArsicNevena TomasevicNKNezrina Kurtanovic
Nezrina Kurtanovic
Rino RagnoRMRužica Micić
Ružica Micić +3
Commercially available pesticides were examined as Mus musculus and Homo sapiens acetylcholinesterase (mAChE and hAChE) inhibitors by means of ligand-based (LB) and structure-based (SB) in silico approaches. Initially, the crystal structures of simazine, monocrotophos, dimethoate, and acetamiprid were reproduced using various force fields. Subsequently, LB alignment rules were assessed and applied to determine the inter synaptic conformations of atrazine, propazine, carbofuran, carbaryl, tebufenozide, imidacloprid, diuron, monuron, and linuron. Afterwards, molecular docking and dynamics SB studies were performed on either mAChE or hAChE, to predict the listed pesticides’ binding modes. Calculated energies of global minima (Eglob_min) and free energies of binding (∆Gbinding) were correlated with the pesticides’ acute toxicities (i.e., the LD50 values) against mice, as well to generate the model that could predict the LD50s against humans. Although for most of the pesticides the low Eglob_min correlates with the high acute toxicity, it is the ∆Gbinding that conditions the LD50 values for all the evaluated pesticides. Derived pLD50 = f(∆Gbinding) mAChE model may predict the pLD50 against hAChE, too. The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides.
1 August 2013 in Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Journal Article
SMSanja Lj Matić
Sanja Lj MatićSSSnežana Stanić
Snežana Stanić
DBDesanka Bogojević
Desanka Bogojević
Melita VidakovicNGNevena Grdović
Nevena GrdovićMMMirjana Mihailović
Mirjana Mihailović +4
6 February 2015 in Food & Function
Journal Article
Jelena S. Katanić StankovićTBTatjana Boroja
Tatjana Boroja
NSNevena Stanković
Nevena Stanković
Vladimir MihailovicMMMilan Mladenović
Milan Mladenović
MVMiroslav M. Vrvić
Miroslav M. Vrvić +1
The purpose of the present study was to evaluate the antioxidant and antimicrobial potential of Filipendula ulmaria (L.) Maxim. methanolic extracts, their stabilities under different pH and thermal conditions and in vitro digestibility. The results showed a considerable content of phenolic compounds in the extracts, especially total phenolic acids (47.47 mg CAE g−1) and flavonoids (45.47 mg RUE g−1) in aerial parts. HPLC analysis indicated the presence of spiraeoside in the aerial part extract. The extracts revealed an interesting antimicrobial effect against the tested microorganisms, especially bacteria E. coli and E. faecalis (MIC 0.156–0.625 mg mL−1), and fungi P. cyclopium and F. oxysporum (MIC 2.5–5 mg mL−1). The extracts exerted high antioxidant activities, particularly the root extract, paralleled by their considerable activities against the lipid oxidation process. The results of this study suggest that both extracts potentially could be functional food ingredients considering their good antioxidant and antimicrobial activities, and stability under different conditions.
1 January 2017 in Food and Chemical Toxicology
Journal Article
Jelena S. Katanić StankovićSMSanja Lj Matić
Sanja Lj MatićEPEva-Maria Pferschy-Wenzig
Eva-Maria Pferschy-Wenzig
Nadine KretschmerTBTatjana Boroja
Tatjana Boroja
Rudolf Bauer +6
6 May 2014 in Food & Function
Journal Article
Vladimir MihailovicJelena S. Katanić StankovićDMDanijela Mišić
Danijela MišićVSVesna Stanković
Vesna StankovićMMMirjana Mihailović
Mirjana MihailovićNSNevena Stanković
Nevena Stanković +4
The objective of this work was to investigate the effects of the methanol extracts of Gentiana cruciata L. aerial parts (GCA) and roots (GCR) against carbon tetrachloride-induced liver injury in rats. Pretreatment with GCA and GCR, containing sweroside, swertiamarin and gentiopicrin in high concentrations, dose-dependently and significantly decreased the levels of serum transaminases, alkaline phosphatase and total bilirubin, whereas an increase in the level of total protein was found compared with the CCl4-treated group. Moreover, oral administration of extracts significantly enhanced antioxidant enzyme activities (superoxide dismutase and catalase), increased the content of glutathione and decreased the content of TBARS. Microscopic evaluations of the liver revealed CCl4-induced lesions and related toxic manifestations that were minimal in the liver of rats pretreated with extracts at the dose of 400 mg per kg b.w. The results suggest that the use of G. cruciata extracts has a merit as a potent candidate in protecting the liver against chemical induced toxicity.
About Me
Dr. Nevena M. Tomašević (née Stanković) has been employed at the Faculty of Science, University of Kragujevac, since 2012, where she currently works as a Teaching Assistant at the Institute of Chemistry. She has received multiple awards as the highest-rated teaching assistant by the Student Parliament and the Faculty. She was awarded a scholarship by the Ministry of Education, Science and Technological Development of the Republic of Serbia for postdoctoral research at the University of Freiburg (Germany), in the group of Prof. Dr. Manfred Jung.
She has been continuously involved in nationally funded research projects since 2012, participating in three national and one international project. She is currently the leader of Work Package 3 within the SMAIPROTACs project funded by the Science Fund of the Republic of Serbia, focused on developing novel therapies for spinal muscular atrophy. Her research interests include biochemistry, medicinal chemistry, and epigenetics.
Dr. Tomašević has authored 29 scientific papers and over 50 conference contributions. She has established international collaborations with researchers from several European countries and beyond. She is a member of the Serbian Chemical Society and the Biochemical Society of Serbia, and she contributed to the organization of their 2024 conference. She is also a co-author of university and primary school textbooks and actively promotes science through outreach activities.
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