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Yuanyuan Li
Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China

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Journal article
Published: 31 July 2021 in Journal of Trace Elements in Medicine and Biology
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We investigated the impacts of plasma levels of magnesium (Mg), zinc (Zn), calcium (Ca), iron (Fe), copper (Cu), selenium (Se), and chromium (Cr) on GDM risk and the potential mediation effect of blood glucose levels on the relationship between trace elements and GDM risk. This nested case-control study was based on data from a birth cohort study conducted in Wuhan, China in 2013−2016. A total of 305 GDM cases and 305 individually-matched controls were included in the study. Conditional logistic regression models were used to estimate the associations between plasma trace element concentrations and GDM risk. A mediation analysis was conducted to explore whether blood glucose levels act as a mediator between trace element levels and GDM risk. An IQR increment in plasma levels of Fe and Cu was associated with a significant increase in GDM risk [OR = 2.04 (95 % CI 1.62, 2.57) and OR = 1.52 (95 % CI 1.25, 1.82)], respectively. On the other hand, an IQR increment in plasma levels of Zn and Ca was associated with a significant decrease in GDM risk [OR = 0.55 (95 % CI 0.43, 0.71) and OR = 0.72 (95 % CI 0.56, 0.92)], respectively. The mediation analysis showed significant mediation of the association between Cu and GDM risk via the FBG (%mediated: 19.27 %), 1 h-PBG (12.64 %), 2h-PBG (28.44 %) pathways. Plasma levels of Zn and Ca were negatively associated with GDM risk, while Fe and Cu were positively associated. Blood glucose levels act as a mediator between plasma trace element exposures and GDM risk.

ACS Style

Gangjiao Zhu; Tongzhang Zheng; Chang Xia; Ling Qi; George D. Papandonatos; Yu Ming; Zhi Zeng; Xichi Zhang; Hongling Zhang; Yuanyuan Li. Plasma levels of trace element status in early pregnancy and the risk of gestational diabetes mellitus: A nested case-control study. Journal of Trace Elements in Medicine and Biology 2021, 68, 126829 .

AMA Style

Gangjiao Zhu, Tongzhang Zheng, Chang Xia, Ling Qi, George D. Papandonatos, Yu Ming, Zhi Zeng, Xichi Zhang, Hongling Zhang, Yuanyuan Li. Plasma levels of trace element status in early pregnancy and the risk of gestational diabetes mellitus: A nested case-control study. Journal of Trace Elements in Medicine and Biology. 2021; 68 ():126829.

Chicago/Turabian Style

Gangjiao Zhu; Tongzhang Zheng; Chang Xia; Ling Qi; George D. Papandonatos; Yu Ming; Zhi Zeng; Xichi Zhang; Hongling Zhang; Yuanyuan Li. 2021. "Plasma levels of trace element status in early pregnancy and the risk of gestational diabetes mellitus: A nested case-control study." Journal of Trace Elements in Medicine and Biology 68, no. : 126829.

Journal article
Published: 24 July 2021 in Ecotoxicology and Environmental Safety
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Arsenic is concerned with cardiovascular diseases including hypertension, atherosclerosis, and endothelial dysfunction. However, what effects the arsenic exposure and the arsenic metabolism have on hypertensive disorders of pregnancy (HDP) and blood pressure changes during pregnancy remain largely unknown. Our goal was to assess the associations of arsenic exposure and arsenic metabolism with HDP and blood pressure changes in pregnant women through a prospective birth cohort study. A total of 1038 women who were pregnant (52 HDP, 986 non-HDP participants) were included. Arsenic species of spot urine samples collected at three trimesters were measured, which included inorganic arsenic (iAs), monomethylated arsenic (MMA), and dimethylated arsenic (DMA). Arsenic metabolism was evaluated as the percentages of iAs, MMA, and DMA respectively (i.e., iAs%, MMA%, and DMA%). Outcomes were HDP and systolic, diastolic, and mean arterial pressure changes during pregnancy. We employed mixed linear models to investigate the relationships between arsenic exposure and arsenic metabolism with changes in blood pressure during pregnancy. Poisson regression with a robust error variance with generalized estimating equations (GEE) estimation was used so that the associations of arsenic exposure and arsenic metabolism with HDP could be estimated. In this study, there was a significant relationship between the concentrations of urinary DMA and the weekly change in systolic blood pressure (SBP) (β = −0.10; 95% CI: −0.15, −0.05), diastolic blood pressure (DBP) (β = −0.07; 95% CI: −0.11, −0.02) and mean arterial pressure (MAP) (β = −0.08; 95% CI: −0.12, −0.04). Higher DMA% was accompanied with lesser weekly increase in SBP (β = −0.05; 95% CI: −0.10, 0.00), DBP (β = −0.06; 95% CI: −0.10, −0.01) and MAP (β = −0.06; 95% CI: −0.09, −0.01) during pregnancy. There was a positive association with the highest tertile of iAs% and weekly change of SBP (β = 0.08; 95% CI: 0.03, 0.13), DBP (β = 0.07; 95% CI: 0.03, 0.11) and MAP (β = 0.07; 95% CI: 0.03, 0.11). No association was found between each arsenic specie and arsenic metabolism marker in the first trimester and risk of HDP. Arsenic exposure and arsenic metabolism during pregnancy potentially change blood pressure of pregnant women. These findings may be significance as even modest elevation of blood pressure can increase the risk of cardiovascular disease.

ACS Style

Xin Wang; Yi Wu; Xiaojie Sun; Qing Guo; Wei Xia; Yongning Wu; Jingguang Li; Shunqing Xu; Yuanyuan Li. Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women. Ecotoxicology and Environmental Safety 2021, 222, 112527 .

AMA Style

Xin Wang, Yi Wu, Xiaojie Sun, Qing Guo, Wei Xia, Yongning Wu, Jingguang Li, Shunqing Xu, Yuanyuan Li. Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women. Ecotoxicology and Environmental Safety. 2021; 222 ():112527.

Chicago/Turabian Style

Xin Wang; Yi Wu; Xiaojie Sun; Qing Guo; Wei Xia; Yongning Wu; Jingguang Li; Shunqing Xu; Yuanyuan Li. 2021. "Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women." Ecotoxicology and Environmental Safety 222, no. : 112527.

Original article
Published: 17 June 2021 in European Journal of Pediatrics
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A growing body of evidence indicates that early-term births (37–38 weeks of gestational age) have an increased risk of short-term and long-term complications. Here, we sought to explore the association between early-term births and the risk of delayed neurodevelopment at age 2 years. Pregnant women and their live singleton birth were recruited from a single tertiary hospital between October 2013 and February 2017. Mental and Psychomotor Development Indexes (MDI and PDI) were assessed using the Bayley Scales of Infant Development (BSID). Delayed neurodevelopment was defined as scores of PDI or MDI less than −1SD relative to the mean score of the study population. In total, 1678 full-term infants and 727 early-term infants were assessed when they were 2 years old. After adjustment for potential confounders, early-term birth was related to 43% increased odds of neurodevelopmental delay in the PDI domain as compared with full-term birth (OR: 1.43; 95% CI: 1.12, 1.82). The observed associations were more prominent among those infants born by cesarean (OR: 1.44; 95% CI: 1.03, 2.00) and among males (OR: 1.66; 95% CI: 1.20, 2.28). No statistical difference in the MDI domain was found between early-term and full-term births. Conclusions: Our findings suggest that early-term birth was associated with increased odds of delayed neurodevelopment in the PDI domain as measured by BSID assessments at age 2 years. Health professionals should be aware of the influence of early-term birth on the risk of delayed neurodevelopment.

ACS Style

Mingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics 2021, 1 -9.

AMA Style

Mingyang Wu, Lulin Wang, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Aifen Zhou, Zhongqiang Cao, Youjie Wang, Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics. 2021; ():1-9.

Chicago/Turabian Style

Mingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. 2021. "Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China." European Journal of Pediatrics , no. : 1-9.

Article
Published: 28 May 2021 in Current Medical Science
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Pregnancy-induced hypertension (PIH), including gestational hypertension and preeclampsia, accounts for the majority of maternal and perinatal morbidity and mortality. Strontium (Sr) has been recently associated with preeclampsia in a small group of women; however, the role of Sr in PIH is not fully understood and warrants further investigation. In this study, we examined the association between urinary Sr levels and PIH, and assessed the effect of maternal age on the association. Urinary Sr concentrations were measured in 5423 pregnant women before delivery by inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression analysis adjusting for potential confounders was applied to explore the association between Sr and PIH, and to evaluate the Sr-PIH relationship stratified by maternal age. Among the participants, 200 (3.83%) women were diagnosed with PIH. Compared with non-PIH women, women who developed PIH had lower urinary Sr concentrations (131.26 vs. 174.98 µg/L creatinine, P<0.01). With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing, the risk of PIH decreased significantly [adjusted OR=0.60 (95%CI: 0.51, 0.72)]. Furthermore, the significant association of Sr with PIH was found among women under 35 years (P<0.01). Our finding suggested that Sr may play a potential protective role in the pathogenesis of PIH, especially among young pregnant women under 35 years old.

ACS Style

Yi Tang; Wei Xia; Shun-Qing Xu; Hong-Xiu Liu; Yuan-Yuan Li. Association of Urinary Strontium Levels with Pregnancy-induced Hypertension. Current Medical Science 2021, 1 -7.

AMA Style

Yi Tang, Wei Xia, Shun-Qing Xu, Hong-Xiu Liu, Yuan-Yuan Li. Association of Urinary Strontium Levels with Pregnancy-induced Hypertension. Current Medical Science. 2021; ():1-7.

Chicago/Turabian Style

Yi Tang; Wei Xia; Shun-Qing Xu; Hong-Xiu Liu; Yuan-Yuan Li. 2021. "Association of Urinary Strontium Levels with Pregnancy-induced Hypertension." Current Medical Science , no. : 1-7.

Journal article
Published: 27 May 2021 in Environment International
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Vitamin D deficiency has been associated with the increased risk of many diseases, especially during early life. Exposure to some toxic metals may decrease vitamin D levels in adults and children in previous studies. However, less is known about the associations of maternal metals exposure during pregnancy with newborns’ vitamin D status. We conducted a prospective cohort study to investigate the relationships between urine metals and metal mixtures during pregnancy and newborns’ vitamin D status. Urine samples of 598 pregnant women were collected in each trimester and cord blood samples of newborns were collected at delivery. The concentrations of 20 metals in urine and 25-hydroxyvitamin D [25(OH)D] in cord serum were quantified. Generalized linear models were used to estimate the associations between individual metals and cord serum total 25(OH)D. We applied Bayesian Kernel Machine Regression (BKMR) to evaluate the mixture and interaction effects of urine metals. In individual metals analyses, we reported that a double increase in urine vanadium (V), cobalt (Co), and thallium (Tl) throughout pregnancy was associated with a 9.91% [95% confidence interval (CI): −18.58%, −0.30%], 11.42% (95% CI: −17.73%, −4.63%), and 12.64% (95% CI: −21.44%, −2.86%) decrease in cord serum total 25(OH)D, respectively. Exposures to the three metals during the whole pregnancy were also correlated to increased odds for newborns’ vitamin D deficiency (<20 ng/mL) [odds ratio (95% CI): 1.80 (1.05, 3.10) for V, 1.88 (1.25, 2.82) for Co, and 1.90 (1.07, 3.38) for Tl]. BKMR analyses revealed a negative influence of metal mixtures (V+Co+Tl) on neonatal vitamin D status, as well as potential synergism between V and Co and between V and Tl. Our study provides evidence of negative impacts of maternal exposure to V, Co, and Tl during pregnancy on cord serum vitamin D levels at delivery. Potential synergism between V and Co and between V and Tl existed in their associations with cord serum total 25(OH)D.

ACS Style

Xingjie Fang; Jingyu Qu; Shu Huan; Xiaojie Sun; Juxiao Li; Qi Liu; Shuna Jin; Wei Xia; Shunqing Xu; Yongning Wu; Jingguang Li; Tongzhang Zheng; Yuanyuan Li. Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations. Environment International 2021, 155, 106660 .

AMA Style

Xingjie Fang, Jingyu Qu, Shu Huan, Xiaojie Sun, Juxiao Li, Qi Liu, Shuna Jin, Wei Xia, Shunqing Xu, Yongning Wu, Jingguang Li, Tongzhang Zheng, Yuanyuan Li. Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations. Environment International. 2021; 155 ():106660.

Chicago/Turabian Style

Xingjie Fang; Jingyu Qu; Shu Huan; Xiaojie Sun; Juxiao Li; Qi Liu; Shuna Jin; Wei Xia; Shunqing Xu; Yongning Wu; Jingguang Li; Tongzhang Zheng; Yuanyuan Li. 2021. "Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations." Environment International 155, no. : 106660.

Journal article
Published: 18 May 2021 in Environment International
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Increasing animal studies have indicated that organophosphate esters (OPEs) have endocrine-disruptive potential. However, human epidemiological evidence is limited, especially in susceptible populations, such as pregnant women and neonates. The purpose of this present study was to examine the trimester-specific relationships of prenatal exposure to OPEs with neonatal thyroid-stimulating hormone (TSH). A total of 102 mother-newborn pairs were recruited from a birth cohort study between April 2015 and September 2016 in Wuhan, China. Eight OPE metabolites were detectable in urine samples from pregnant women across the different three trimesters. Neonatal TSH levels were measured using time-resolved immunofluorescence assay. The associations between maternal urinary OPE metabolites and neonatal TSH and the critical exposure windows of fetal vulnerability were estimated using multiple informant models. Seven OPE metabolites with detection frequency > 50% (52.9%–98.0%) were detected in repeated urine samples from different three trimesters, and the urinary OPE metabolites across pregnancy was of high variability (ICCs: 0.09–0.26). After adjusted for confounders (e.g., maternal age, prepregnancy BMI, passive smoking during pregnancy), some suggestive associations were observed between maternal urinary OPE metabolites and neonatal TSH in different trimesters. A doubling of second trimester di-o-cresyl phosphate & di-p-cresyl phosphate (DoCP & DpCP) was associated with a 7.82% increase in neonatal TSH level (95% CI: −0.70%, 17.06%, p-value = 0.07), a doubling of third trimester diphenyl phosphate (DPHP) was associated with a 4.71% decrease in neonatal TSH level (95% CI: –9.80%, 0.67%, p-value = 0.09), and a doubling of third trimester bis(2-butoxyethyl) phosphate (BBOEP) was associated with a 6.38% increase in neonatal TSH level (95% CI: −0.12%, 13.31%, p = 0.05). However, such associations did not differ materially across trimesters. When performing stratified analysis by infant sex, the associations were statistically significant and were sex-dependent. In females, maternal urinary DoCP & DpCP concentrations in each trimester were associated with increased neonatal TSH levels, and urinary DPHP concentration in the third trimester was associated with decreased neonatal TSH level. In males, maternal urinary BBOEP concentration in the first trimester was positively related to neonatal TSH level. This prospective study demonstrated that prenatal exposure to OPEs can lead to a sex-dependent change in neonatal TSH levels. Although the sex-selective effect was differed among various urinary OPE metabolites, more evidence was supported that OPE exposure was related to increased TSH levels for both males and females.

ACS Style

Yun Tao; Liqin Hu; Ling Liu; Meng Yu; Yaping Li; Xiang Li; Wenyu Liu; Dan Luo; Adrian Covaci; Wei Xia; Shunqing Xu; Yuanyuan Li; Surong Mei. Prenatal exposure to organophosphate esters and neonatal thyroid-stimulating hormone levels: A birth cohort study in Wuhan, China. Environment International 2021, 156, 106640 .

AMA Style

Yun Tao, Liqin Hu, Ling Liu, Meng Yu, Yaping Li, Xiang Li, Wenyu Liu, Dan Luo, Adrian Covaci, Wei Xia, Shunqing Xu, Yuanyuan Li, Surong Mei. Prenatal exposure to organophosphate esters and neonatal thyroid-stimulating hormone levels: A birth cohort study in Wuhan, China. Environment International. 2021; 156 ():106640.

Chicago/Turabian Style

Yun Tao; Liqin Hu; Ling Liu; Meng Yu; Yaping Li; Xiang Li; Wenyu Liu; Dan Luo; Adrian Covaci; Wei Xia; Shunqing Xu; Yuanyuan Li; Surong Mei. 2021. "Prenatal exposure to organophosphate esters and neonatal thyroid-stimulating hormone levels: A birth cohort study in Wuhan, China." Environment International 156, no. : 106640.

Journal article
Published: 15 May 2021 in Journal of Trace Elements in Medicine and Biology
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The immunotoxicity induced by vanadium exposure have been reported in some toxicology researches. However, evidence from population-based epidemiological studies was lacking. This study was conducted to assess the associations between prenatal and postnatal exposure to vanadium and immune function of children. A total of 407 pre-school aged children were followed, whose peripheral blood was collected for T lymphocyte subsets and inflammatory cytokines analysis, as well as vanadium concentration measurement. Maternal urine samples were also collected to measure vanadium concentration. We used generalized linear models to evaluate the associations of maternal and children vanadium concentration with children’s immune function. Stratification analysis was further conducted to explore the potential gender-specific effects. The geometric means of vanadium concentration in maternal urine and children plasma were 0.85 and 1.12 μg/L, respectively. Maternal urinary vanadium was inversely associated with the percentage of CD3+CD4+ cells [-5.53 % (-10.38 %, -0.41 %)] and absolute counts of CD3+ cells [-2.43 % (-5.05 %, 0.25 %)], and we only observed significant negative associations in males when stratifying by fetal gender. Children plasma vanadium was also associated with reduced absolute counts of CD3+ cells [-5.25 % (-9.57 %, -0.73 %)], but gender-specific effects were not observed. No significant associations of vanadium exposure with cytokines were found. Prenatal and postnatal exposure to vanadium had suppressive impacts on childhood cellular immune. Further studies are needed to confirm our findings.

ACS Style

Wenxin Zhang; Huan Chen; Qiang Zeng; Shunqing Xu; Wei Xia; Yuanyuan Li. Prenatal and postnatal exposure to vanadium and the immune function of children. Journal of Trace Elements in Medicine and Biology 2021, 67, 126787 .

AMA Style

Wenxin Zhang, Huan Chen, Qiang Zeng, Shunqing Xu, Wei Xia, Yuanyuan Li. Prenatal and postnatal exposure to vanadium and the immune function of children. Journal of Trace Elements in Medicine and Biology. 2021; 67 ():126787.

Chicago/Turabian Style

Wenxin Zhang; Huan Chen; Qiang Zeng; Shunqing Xu; Wei Xia; Yuanyuan Li. 2021. "Prenatal and postnatal exposure to vanadium and the immune function of children." Journal of Trace Elements in Medicine and Biology 67, no. : 126787.

Original research article
Published: 30 April 2021 in Frontiers in Psychiatry
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Background: The outbreak of novel coronavirus disease 2019 (COVID-19) has caused public panic and psychological health problems, especially in medical staff. We aimed to investigate the psychological effect of the COVID-19 outbreak on medical staff. Methods: A cross-sectional study was conducted to examine the psychological impact of medical staff working in COVID-19 designated hospitals from February to March 2020 in China. We assessed psychological health problems using the Symptom Check List 90 (SCL-90). Results: Among 656 medical staff, 244 were frontline medical staff and 412 general medical staff. The prevalence of psychological health problems was 19.7%. The SCL-90 scores in frontline medical staff were significantly higher than that in general medical staff (mean: 141.22 vs. 129.54, P < 0.05). Furthermore, gender [odds ratio (OR) = 1.53, 95% CI = (1.02, 2.30), P = 0.042 for female vs. male] and the burden of current work [OR = 7.55, 95% CI = (3.75, 15.21), P < 0.001 for high burden; OR = 2.76, 95% CI = (1.80, 4.24), P < 0.001 for moderate burden vs. low burden] were associated with increased risk of poor psychological status. Conclusions: Medical staff experienced a high risk of psychological health problems during the outbreak of COVID-19, especially for frontline medical staff. Psychological health services are expected to arrange for medical staff in future unexpected infectious disease outbreaks.

ACS Style

Jun Xie; Qi Liu; Xiaobing Jiang; Upasana Manandhar; Zhen Zhu; Yuanyuan Li; Bo Zhang. Psychological Health Issues of Medical Staff During the COVID-19 Outbreak. Frontiers in Psychiatry 2021, 12, 611223 .

AMA Style

Jun Xie, Qi Liu, Xiaobing Jiang, Upasana Manandhar, Zhen Zhu, Yuanyuan Li, Bo Zhang. Psychological Health Issues of Medical Staff During the COVID-19 Outbreak. Frontiers in Psychiatry. 2021; 12 ():611223.

Chicago/Turabian Style

Jun Xie; Qi Liu; Xiaobing Jiang; Upasana Manandhar; Zhen Zhu; Yuanyuan Li; Bo Zhang. 2021. "Psychological Health Issues of Medical Staff During the COVID-19 Outbreak." Frontiers in Psychiatry 12, no. : 611223.

Journal article
Published: 11 April 2021 in Environmental Pollution
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Prenatal fine particulate matter (PM2.5) exposure has been associated with impaired offspring neurodevelopment; however, the association of PM2.5 exposure during preconception with offspring’s neurodevelopment and factors responsible for this association are still unclear. This study estimated the associations of PM2.5 exposure during preconception and the first trimester with offspring neurodevelopment and evaluated whether maternal thyroid hormones mediate these associations. We recruited 1329 mother-child pairs between 2013 and 2015 in Wuhan, China. PM2.5 exposure levels of each woman during the 3 months preconception and the first trimester were estimated using land-use regression models. Offspring neurodevelopment characterized by mental developmental index (MDI) and psychomotor developmental index (PDI) were measured at 24 months of age. Maternal serum levels of free thyroxine (FT3), free triiodothyronine (FT4), and thyroid-stimulating hormone (TSH) during early pregnancy were measured of a subset of the 1329 women (551 women). Generalized estimation equation and general linear regression models were used to estimate the associations between maternal PM2.5 exposure, thyroid hormones, and offspring neurodevelopment. After adjusting for potential confounders, we found that either among all participants or the subset, PM2.5 exposure during preconception and the first trimester was negatively associated with offspring PDI. Double increment in the first trimester PM2.5 exposure was significantly associated with 3.43 and 6.48 points decrease in offspring MDI. In the subset, each doubling of PM2.5 exposure during preconception and the first trimester was significantly associated with 7.93 and 8.02 points decrease in maternal FT4 level, respectively. Increased maternal FT4, in turn, was associated with increased PDI (β = 16.69, 95% CI: 5.39, 27.99). About 7.7% (95% CI: 2.0%–19.4%) and 8.6% (95% CI: 3.0%, 22.1%) of the effect of PM2.5 exposure during preconception on offspring PDI was mediated through maternal FT4 and the FT4/FT3 ratio, respectively.

ACS Style

Juxiao Li; Jiaqiang Liao; Chen Hu; Shuangshuang Bao; Gaga Mahai; Zhongqiang Cao; Chunye Lin; Wei Xia; Shunqing Xu; Yuanyuan Li. Preconceptional and the first trimester exposure to PM2.5 and offspring neurodevelopment at 24 months of age: Examining mediation by maternal thyroid hormones in a birth cohort study. Environmental Pollution 2021, 284, 117133 .

AMA Style

Juxiao Li, Jiaqiang Liao, Chen Hu, Shuangshuang Bao, Gaga Mahai, Zhongqiang Cao, Chunye Lin, Wei Xia, Shunqing Xu, Yuanyuan Li. Preconceptional and the first trimester exposure to PM2.5 and offspring neurodevelopment at 24 months of age: Examining mediation by maternal thyroid hormones in a birth cohort study. Environmental Pollution. 2021; 284 ():117133.

Chicago/Turabian Style

Juxiao Li; Jiaqiang Liao; Chen Hu; Shuangshuang Bao; Gaga Mahai; Zhongqiang Cao; Chunye Lin; Wei Xia; Shunqing Xu; Yuanyuan Li. 2021. "Preconceptional and the first trimester exposure to PM2.5 and offspring neurodevelopment at 24 months of age: Examining mediation by maternal thyroid hormones in a birth cohort study." Environmental Pollution 284, no. : 117133.

Research article
Published: 01 April 2021 in Hypertension
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Ambient fine particulate matter (PM 2.5 ) exposure during pregnancy was associated with hypertensive disorders of pregnancy (HDP) in previous studies, however, the results were inconsistent. In addition, its effects on blood pressure (BP) pattern, which was different between normal pregnancy and pregnancy with HDP, remain unclear. In this study, we estimate daily PM 2.5 exposure levels of 7658 pregnant women from a prospective cohort study in Wuhan, China, using land use regression model. BP was repeatedly measured in each trimester. Linear mixed-effect model was used to examine associations of PM 2.5 exposure with BP patterns during pregnancy. The association between PM 2.5 exposure and HDP was estimated by modified Poisson regression. In the lowest quartile of PM 2.5 exposure, BP fell gradually during early pregnancy and increase subsequently after a nadir at mid-pregnancy. In higher quartiles of PM 2.5 exposure, a slower drop of BP was observed during early pregnancy, and the mid-pregnancy drop was less obvious compared with the lowest quartile. PM 2.5 exposure during the second trimester was positively associated with the risk of HDP (relative risk =1.42 [95% CI, 1.19–1.70]), especially among women with excessive gestational weight gain (relative risk =1.48 [95% CI, 1.16–1.90; P for interaction =0.03). Our study suggests that PM 2.5 exposure might play an important role in BP pattern during pregnancy and might increase the risk of HDP, especially among women with excessive gestational weight gain.

ACS Style

Yu Zhang; Juxiao Li; Jiaqiang Liao; Chen Hu; Zhongqiang Cao; Wei Xia; Shunqing Xu; Yuanyuan Li. Impacts of Ambient Fine Particulate Matter on Blood Pressure Pattern and Hypertensive Disorders of Pregnancy. Hypertension 2021, 77, 1133 -1140.

AMA Style

Yu Zhang, Juxiao Li, Jiaqiang Liao, Chen Hu, Zhongqiang Cao, Wei Xia, Shunqing Xu, Yuanyuan Li. Impacts of Ambient Fine Particulate Matter on Blood Pressure Pattern and Hypertensive Disorders of Pregnancy. Hypertension. 2021; 77 (4):1133-1140.

Chicago/Turabian Style

Yu Zhang; Juxiao Li; Jiaqiang Liao; Chen Hu; Zhongqiang Cao; Wei Xia; Shunqing Xu; Yuanyuan Li. 2021. "Impacts of Ambient Fine Particulate Matter on Blood Pressure Pattern and Hypertensive Disorders of Pregnancy." Hypertension 77, no. 4: 1133-1140.

Journal article
Published: 18 January 2021 in Environment International
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The association between exposure to organochlorine pesticides (OCPs) and infant growth has been reported contradictorily in previous studies. Few studies have investigated the effects of prenatal exposure to OCPs on infant growth assessed longitudinally at multiple time points. The purpose of the study was to examine the associations between prenatal exposure to OCPs and infant growth at birth, 6, 12 and 24 months of age, and further to explore the potential sex-specific effects. The study population included 1039 mother-infant pairs who participated in a birth cohort study in Wuhan, China. The weight, length and body mass index (BMI) z-score of infants were measured and calculated at birth, 6, 12 and 24 months of age. The overweight status was defined as BMI z-score ≥ 85th percentile according to the standard of World Health Organization. The concentrations of OCPs were measured in cord serum, including hexachlorocyclohexanes (HCHs, consisted of α-HCH, β-HCH, and γ-HCH), p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) and its metabolites: p,p′-dichlorodiphenyldichloroethane (p,p′-DDD), and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE). Generalized linear models were applied to estimate the associations of cord OCPs with infant growth parameters. A group-based semiparametric mixture model was used to estimate growth patterns of infants. Linear-mixed growth curve models were used to examine relationships between predicted growth trajectories and prenatal exposure to OCPs. Weighted quantile sum regression (WQSR) analyses were used to estimate the mixture effects of OCPs on infant growth. Higher cord serum β-HCH concentrations were associated with higher BMI z-score at 12 [β = 0.07, 95%CI: 0.01, 0.13] and 24 months of age [β = 0.08, 95% CI: 0.02, 0.14]. Similar patterns were observed for relationships of γ-HCH [β = 0.04, 95%CI: 0.01, 0.07] and p,p′-DDT [β = 0.03, 95% CI: 0.00, 0.06] with BMI z-score at 6 and 12 months of age, respectively. However, higher cord serum p,p′-DDE concentrations were associated with a reduction of BMI z-score at 6 months of age [β = −0.07, 95% CI: −0.12, −0.01]. Cord serum β-HCH was also positively associated with the risk of overweight at 12 months of age [RR = 1.16, 95% CI (1.02, 1.33), for the medium vs the lowest tertile]. Among girls, the effects of β-HCH on BMI z-score and overweight status were stronger than boys at 12 and 24 months of age. No statistically significant relationships of other OCPs with infant growth were observed. Prenatal exposure to β-HCH was associated with increased BMI z-score and higher risk of overweight status in infants especially at 12 and 24 months of age, which seemed to be stronger in girls.

ACS Style

Chenhui Yang; Jing Fang; Xiaojie Sun; Wenxin Zhang; Juxiao Li; Xiaomei Chen; Ling Yu; Wei Xia; Shunqing Xu; Zongwei Cai; Yuanyuan Li. Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study. Environment International 2021, 148, 106374 .

AMA Style

Chenhui Yang, Jing Fang, Xiaojie Sun, Wenxin Zhang, Juxiao Li, Xiaomei Chen, Ling Yu, Wei Xia, Shunqing Xu, Zongwei Cai, Yuanyuan Li. Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study. Environment International. 2021; 148 ():106374.

Chicago/Turabian Style

Chenhui Yang; Jing Fang; Xiaojie Sun; Wenxin Zhang; Juxiao Li; Xiaomei Chen; Ling Yu; Wei Xia; Shunqing Xu; Zongwei Cai; Yuanyuan Li. 2021. "Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study." Environment International 148, no. : 106374.

Journal article
Published: 15 December 2020 in Journal of Hazardous Materials
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Neurotoxicity of organophosphate esters (OPEs) has been reported in toxicological studies, but epidemiological findings are limited. We aimed to assess the associations between prenatal OPE exposures and children’s neurodevelopment at 2 years old. We measured urinary concentrations of OPEs collected in the first and third trimester from 184 pregnant women in Wuhan, China. Childhood neurodevelopment was assessed using the Chinese revision of Bayley Scale of Infant Development. A two-fold increase in the average of bis (1,3-dichloro-2-propyl) phosphate (BDCIPP) was associated with 3.50 decrease in Psychomotor Development Index (PDI) score (95%CI: −5.86, −1.14) and 5.75 decrease in Mental Development Index (MDI) score (95%CI: −8.94, −2.55). Average of the molar concentrations of chlorinated-alkyl OPEs (ΣCl-OPEs) during pregnancy was inversely associated with PDI [β = −3.24 (95%CI: −5.95, −0.53)] and MDI scores [β = −5.86 (95%CI: −9.52, −2.20)]. Prenatal concentrations of BDCIPP and ΣCl-OPEs were inversely associated with neurodevelopment scores in boys, but not in girls. Our study provides evidence that elevated prenatal exposure to chlorinated-alkyl OPEs especially BDCIPP might be inversely associated with childhood neurodevelopment, and the effect seems to be sex-specific.

ACS Style

Wenyu Liu; Dan Luo; Wei Xia; Yun Tao; Limei Wang; Meng Yu; Liqin Hu; Aifen Zhou; Adrian Covaci; Chunye Lin; Shunqing Xu; Surong Mei; Yuanyuan Li. Prenatal exposure to halogenated, aryl, and alkyl organophosphate esters and child neurodevelopment at two years of age. Journal of Hazardous Materials 2020, 408, 124856 .

AMA Style

Wenyu Liu, Dan Luo, Wei Xia, Yun Tao, Limei Wang, Meng Yu, Liqin Hu, Aifen Zhou, Adrian Covaci, Chunye Lin, Shunqing Xu, Surong Mei, Yuanyuan Li. Prenatal exposure to halogenated, aryl, and alkyl organophosphate esters and child neurodevelopment at two years of age. Journal of Hazardous Materials. 2020; 408 ():124856.

Chicago/Turabian Style

Wenyu Liu; Dan Luo; Wei Xia; Yun Tao; Limei Wang; Meng Yu; Liqin Hu; Aifen Zhou; Adrian Covaci; Chunye Lin; Shunqing Xu; Surong Mei; Yuanyuan Li. 2020. "Prenatal exposure to halogenated, aryl, and alkyl organophosphate esters and child neurodevelopment at two years of age." Journal of Hazardous Materials 408, no. : 124856.

Journal article
Published: 03 December 2020 in Journal of Hazardous Materials
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Organophosphate flame retardants (OPFRs) are substantially applied as flame retardants and plasticizers in consumer products. Although the embryonic developmental toxicity of OPFRs has been reported, human data are limited and the critical windows of susceptibility to OPFRs exposure urgently need to be identified. Here, we investigated the trimester-specific associations between prenatal OPFR exposure and birth size for the first time. The concentrations of 15 OPFR metabolites and tris(2-chloroethyl) phosphate were repeatedly determined in urine samples of 213 pregnant women collected in the first, second, and third trimesters in Wuhan, China, and anthropometric data were retrieved from medical records. In multiple informant models, urinary concentrations of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and bis(2-butoxyethyl) phosphate (BBOEP) in the third trimester, 4-hydroxyphenyl-diphenyl phosphate (4-HO-DPHP) in the second trimester, and diphenyl phosphate (DPHP) in the first trimester were negatively associated with birth weight, among which a significant difference in exposure-effect relationships across the three trimesters was observed for BDCIPP. BBOEP concentrations in the third trimester were negatively correlated to birth length with significant varying exposure effects. Our results suggest that prenatal exposure to certain OPFRs may impair fetal growth, and the fetus is vulnerable to the developmental toxicity of BDCIPP and BBOEP in the third trimester.

ACS Style

Dan Luo; Wenyu Liu; Weixiang Wu; Yun Tao; Liqin Hu; Limei Wang; Meng Yu; Aifen Zhou; Adrian Covaci; Wei Xia; Shunqing Xu; Yuanyuan Li; Surong Mei. Trimester-specific effects of maternal exposure to organophosphate flame retardants on offspring size at birth: A prospective cohort study in China. Journal of Hazardous Materials 2020, 406, 124754 .

AMA Style

Dan Luo, Wenyu Liu, Weixiang Wu, Yun Tao, Liqin Hu, Limei Wang, Meng Yu, Aifen Zhou, Adrian Covaci, Wei Xia, Shunqing Xu, Yuanyuan Li, Surong Mei. Trimester-specific effects of maternal exposure to organophosphate flame retardants on offspring size at birth: A prospective cohort study in China. Journal of Hazardous Materials. 2020; 406 ():124754.

Chicago/Turabian Style

Dan Luo; Wenyu Liu; Weixiang Wu; Yun Tao; Liqin Hu; Limei Wang; Meng Yu; Aifen Zhou; Adrian Covaci; Wei Xia; Shunqing Xu; Yuanyuan Li; Surong Mei. 2020. "Trimester-specific effects of maternal exposure to organophosphate flame retardants on offspring size at birth: A prospective cohort study in China." Journal of Hazardous Materials 406, no. : 124754.

Research article
Published: 06 September 2020 in Phytotherapy Research
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Exposure to PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm) has been associated with increased cardiopulmonary outcomes, mediated by a hypothesized biological mechanism of systemic inflammation and oxidation. This randomized, double‐blinded and placebo‐controlled trial among 120 healthy adults in Wuhan, China, was conducted to evaluate whether the supplementation of herbal product composed of Ginseng, Lilii Bulbus and Poria (GLP) which have been shown to have anti‐inflammatory and anti‐oxidant activity offers protective effects on PM2.5‐induced damage to cardiopulmonary health. Participants received four rounds of health examinations and two rounds of blood sample collection from November 2018 to January 2019. Compared to the placebo group, the GLP group showed significant increased antioxidant biomarkers such as superoxide dismutase (SOD) and paraoxonase1 (PON1). What is more, interleukin‐6 (IL‐6), an inflammatory biomarker, was significantly decreased in the GLP group. In addition, nitric oxide and club cell secretory protein (CC16) were increased but heart rate was decreased in the GLP group. As for pulmonary function indicators, significantly increased fractional exhaled nitric oxide (FeNO) was observed in the GLP group. Taken together, we concluded that GLP supplementation is associated with decreased inflammatory biomarker and increased antioxidant biomarkers suggesting cardiopulmonary benefits against PM2.5 exposure among young adults in China.

ACS Style

Feng Qiu; Liang Chen; Hanjin Wang; Min Huang; Xiaojie Sun; Juntao Kan; Jun Du; Yuanyuan Li. Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM 2 .5 in air pollution‐induced cardiopulmonary damage among adults. Phytotherapy Research 2020, 35, 877 -887.

AMA Style

Feng Qiu, Liang Chen, Hanjin Wang, Min Huang, Xiaojie Sun, Juntao Kan, Jun Du, Yuanyuan Li. Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM 2 .5 in air pollution‐induced cardiopulmonary damage among adults. Phytotherapy Research. 2020; 35 (2):877-887.

Chicago/Turabian Style

Feng Qiu; Liang Chen; Hanjin Wang; Min Huang; Xiaojie Sun; Juntao Kan; Jun Du; Yuanyuan Li. 2020. "Protective effect of supplementation with Ginseng, Lilii Bulbus and Poria against PM 2 .5 in air pollution‐induced cardiopulmonary damage among adults." Phytotherapy Research 35, no. 2: 877-887.

Journal article
Published: 03 September 2020 in Science of The Total Environment
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Previous studies on environmental pollutant exposure during pregnancy have mostly focused on individual chemical substances or single urine measurements. Thus, our understanding of the potential cumulative or interactive effects of exposure is limited. We aimed to ascertain the characteristics and predictors of exposure to environmental chemicals over three trimesters among pregnant women. We measured the concentrations of 34 chemicals in spot urine samples provided by 745 participants in their early, middle, and late pregnancy. We calculated Spearman correlation coefficients (SCC) between exposure levels of multiple chemicals in each trimester. K-means clustering and principal components analysis (PCA) were applied to classify the populations and reduce data dimensionality. We used generalized linear models (GLM) to confirm predictors of each cluster and principal component. SCC showed that the correlations of chemical concentrations from the same classes were higher than those among concentrations of different classes. Cluster analysis categorized participants into three clusters, and each cluster represented different chemical concentrations. We restricted the principal components to six, which explained more than 50% of the data variations. Several physiological, socio-demographic factors, and behavior patterns were related to different clusters and principal components. Distinct exposure patterns and dominant exposure components of multiple environmental chemicals among pregnant women might help research the potential health effects of exposure to chemical mixtures and develop relevant public health interventions.

ACS Style

Huan Chen; Wenxin Zhang; Yanqiu Zhou; Jiufeng Li; Hongzhi Zhao; Shunqing Xu; Wei Xia; Zongwei Cai; Yuanyuan Li. Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China. Science of The Total Environment 2020, 754, 142167 .

AMA Style

Huan Chen, Wenxin Zhang, Yanqiu Zhou, Jiufeng Li, Hongzhi Zhao, Shunqing Xu, Wei Xia, Zongwei Cai, Yuanyuan Li. Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China. Science of The Total Environment. 2020; 754 ():142167.

Chicago/Turabian Style

Huan Chen; Wenxin Zhang; Yanqiu Zhou; Jiufeng Li; Hongzhi Zhao; Shunqing Xu; Wei Xia; Zongwei Cai; Yuanyuan Li. 2020. "Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China." Science of The Total Environment 754, no. : 142167.

Journal article
Published: 09 July 2020 in Environment International
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Mitochondria are sensitive to environmental toxicants due to the limited repair capacity. Exposure to benzotriazoles (BTRs) and benzothiazoles (BTHs) may contribute to adverse health outcomes through oxidative stress, which may interfere with mitochondrial function. However, the mitochondrial effects of exposure to BTs (BTRs and BTHs) have not yet been elucidated, particularly in human investigations. We examined the associations between trimester-specific urinary BTRs and BTHs concentrations and cord blood mitochondrial DNA copy number (mtDNAcn) in a prospective birth cohort. The present study included 742 mother-infant pairs who participated in a birth cohort between 2014 and 2015 in Wuhan and had data on urinary concentrations of BTRs and BTHs and mtDNAcn in cord blood. Concentrations of BTs were repeatedly measured in maternal urine samples at different trimesters using high performance liquid chromatography-tandem mass spectrometry. Relative mtDNAcn in umbilical cord blood was analyzed by quantitative real-time polymerase chain reaction. Generalized estimating equations were used to evaluate the associations between BTs exposure across gestation and mtDNAcn in cord blood. In the present study, we observed a positive association between urinary 2-methylthio-benzothiazole (2-MeS-BTH) concentrations in the first trimester and cord blood mtDNAcn, with marginal significance [percent changes (%Δ) = 3.97, 95% confidence interval (CI): −0.05, 8.16, p = 0.05], while urinary 2-amino-benzothiazole concentrations in the third trimester were significantly negatively associated with cord blood mtDNAcn (%Δ = −5.89, 95% CI: −10.32, −1.24). Similar patterns of associations were demonstrated between urinary 1-H-benzotriazole (1-H-BTR) and xylyltriazole concentrations in the third trimester and cord blood mtDNAcn (%Δ = −4.18 to −3.23). In sex-specific analysis, we identified that maternal urinary 1-H-BTR in the first trimester and 2-MeS-BTH in the third trimester were positively associated with cord blood mtDNAcn among male infants but not female (P for interaction = 0.05 for 1-H-BTR, P for interaction = 0.05 for 2-MeS-BTH, respectively). We found evidence that prenatal exposure to BTRs and BTHs were associated with cord blood mtDNAcn alternation, and these associations were modified by infant gender. Further investigations are needed to corroborate these findings.

ACS Style

Xiaomei Chen; Yanqiu Zhou; Chen Hu; Wei Xia; Shunqing Xu; Zongwei Cai; Yuanyuan Li. Prenatal exposure to benzotriazoles and benzothiazoles and cord blood mitochondrial DNA copy number: A prospective investigation. Environment International 2020, 143, 105920 .

AMA Style

Xiaomei Chen, Yanqiu Zhou, Chen Hu, Wei Xia, Shunqing Xu, Zongwei Cai, Yuanyuan Li. Prenatal exposure to benzotriazoles and benzothiazoles and cord blood mitochondrial DNA copy number: A prospective investigation. Environment International. 2020; 143 ():105920.

Chicago/Turabian Style

Xiaomei Chen; Yanqiu Zhou; Chen Hu; Wei Xia; Shunqing Xu; Zongwei Cai; Yuanyuan Li. 2020. "Prenatal exposure to benzotriazoles and benzothiazoles and cord blood mitochondrial DNA copy number: A prospective investigation." Environment International 143, no. : 105920.

Journal article
Published: 01 June 2020 in Environmental Toxicology and Pharmacology
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To investigate the association between urinary vanadium concentrations and blood pressure (BP) changes in Chinese pregnant women. This longitudinal study included 716 pregnant women who visited our hospital in Wuhan, China, from 2014 to 2016. Urinary sample collection and BP measurements were performed at 9–15, 21–27, and 34–40 weeks of gestation. Outcomes were repeated BP measurements (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) during pregnancy. The geometric mean of urinary vanadium concentrations was 0.65 μg/g creatinine. After adjusting for potential confounders, each threefold increase in urinary vanadium concentration was observed to be associated with a 1.06 mmHg decrease in SBP (95 % confidence interval [CI]: −1.80, −0.32), a 0.68 mmHg decrease in DBP (95 % CI: −1.32, −0.04), and a 0.81 mmHg decrease in MAP (95 % CI: −1.42, −0.19). Cross-sectional analysis showed a negative association between urinary vanadium concentrations and BP in the third trimester. Specifically, each threefold increase in urinary vanadium concentration in the second trimester was associated with decreases in SBP, DBP, PP, and MAP by 2.72 mmHg (95 % CI: −4.02, −1.41), 1.57 mmHg (95 % CI: −2.72, −0.42), 1.14 mmHg (95 % CI: −2.15, −0.14), and 1.95 mmHg (95 % CI: −3.06, −0.85), respectively, in the third trimester. To the best of our knowledge, this is the first longitudinal study that suggests the negative association between vanadium exposure and BP among pregnant women in China.

ACS Style

Lin Qiu; Shunqing Xu; Aifen Zhou; Wenyu Liu; Jiaqiang Liao; Zhongqiang Cao; Zhong Chen; Cong Yao; Yaqi Zhang; Yuanyuan Li. Association between changes in gestational blood pressure and vanadium exposure in China. Environmental Toxicology and Pharmacology 2020, 79, 103424 .

AMA Style

Lin Qiu, Shunqing Xu, Aifen Zhou, Wenyu Liu, Jiaqiang Liao, Zhongqiang Cao, Zhong Chen, Cong Yao, Yaqi Zhang, Yuanyuan Li. Association between changes in gestational blood pressure and vanadium exposure in China. Environmental Toxicology and Pharmacology. 2020; 79 ():103424.

Chicago/Turabian Style

Lin Qiu; Shunqing Xu; Aifen Zhou; Wenyu Liu; Jiaqiang Liao; Zhongqiang Cao; Zhong Chen; Cong Yao; Yaqi Zhang; Yuanyuan Li. 2020. "Association between changes in gestational blood pressure and vanadium exposure in China." Environmental Toxicology and Pharmacology 79, no. : 103424.

Journal article
Published: 12 May 2020 in Science of The Total Environment
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The excess or deficiency of trace metals can cause adverse neurocognitive development. Evidence of health effect of trace metal mixtures on neurocognitive development is limited in children. We evaluated associations of prenatal exposure to trace metals and metal mixtures with neurocognitive development of 2-year-old children. A total of 544 mother-child pairs were included in the study. The concentrations of 10 trace metals in maternal urine were monitored before delivery. Neurocognitive development indexes, including mental development index (MDI) and psychomotor development index (PDI), were assessed using the Bayley Scales of Infant Development. Linear regression analysis was performed to explore the effects of single-metal and multi-metal exposures. Bayesian Kernel Machine regression (BKMR) was used to investigate overall effect of exposure to metal mixtures and potential interactions among mixture components. We found positive associations of urinary strontium (Sr) and Selenium (Se) levels with MDI scores among all children in the single-metal model. Sr was positively related to MDI, while Manganese (Mn) was negatively associated with PDI in the multi-metal model. The results from BKMR model in girls revealed that MDI scores were improved with the increasing concentrations of Sr, Se and Mn mixture until the concentrations reached their 30th percentiles (Sr: 149.49 μg/g creatinine, Se:18.38 μg/g creatinine, Mn:1.96 μg/g creatinine), with no effect after that threshold level. Sr played a positive role in mental development among mixture components, which was consistent with the results of Sr in the multi-metal models. No signification association of mixture with MDI/PDI was found in boys. The study suggested potential sex-specific association of Sr, Se and Mn mixture levels (at or below their 30th percentiles) with improved mental development, and beneficial role of Sr.

ACS Style

Chunhui Li; Wei Xia; Yangqian Jiang; Wenyu Liu; Bin Zhang; Shunqing Xu; Yuanyuan Li. Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children. Science of The Total Environment 2020, 735, 139403 .

AMA Style

Chunhui Li, Wei Xia, Yangqian Jiang, Wenyu Liu, Bin Zhang, Shunqing Xu, Yuanyuan Li. Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children. Science of The Total Environment. 2020; 735 ():139403.

Chicago/Turabian Style

Chunhui Li; Wei Xia; Yangqian Jiang; Wenyu Liu; Bin Zhang; Shunqing Xu; Yuanyuan Li. 2020. "Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children." Science of The Total Environment 735, no. : 139403.

Original article
Published: 24 March 2020 in European Journal of Pediatrics
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The aim of our study was to investigate the relationship between maternal age at menarche and newborn telomere length which has been linked to lifespan and many age-related diseases. There were 734 mother-newborn pairs recruited from Wuhan Children’s Hospital Wuhan, Hubei Province, China. Age at menarche was self-reported and categorized into three groups (≤ 12 years, 13 years, and ≥ 14 years). Telomere length in cord blood was measured using quantitative real-time polymerase chain reaction and expressed as the ratio of telomere copy number to single-copy gene number (T/S). The mean age at menarche of 734 mothers was 13.1 (± 1.1) years and the adjusted geometric means in the T/S of newborn telomeres in the three groups were 0.693, 0.721, and 0.748 respectively. Earlier age at menarche (≤ 12 years), compared with later age at menarche ≥ 14 years, was significantly associated with 7.32% (95% CI − 13.70%, − 0.23%) shorter telomere length in offspring after adjusting for potential confounders. Conclusion: Mothers with earlier age at menarche were more likely to give birth newborn with shorter telomere length. Our study provides evidences for the effect of earlier menarche on fetal telomere programming in offspring.

ACS Style

Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics 2020, 179, 1507 -1513.

AMA Style

Lulin Wang, Lulu Song, Bingqing Liu, Lina Zhang, Mingyang Wu, Wei Xia, Yuanyuan Li, Chao Xiong, Zhongqiang Cao, Shunqing Xu, Bin Zhang, Yaohua Tian, Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics. 2020; 179 (10):1507-1513.

Chicago/Turabian Style

Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. 2020. "Earlier maternal menarche is associated with shorter newborn telomere length." European Journal of Pediatrics 179, no. 10: 1507-1513.

Other
Published: 08 March 2020
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BackgroundThe ongoing outbreak of novel corona virus disease 2019 (COVID-19) in Wuhan, China, is arousing international concern. This study evaluated whether and when the infected but asymptomatic cases during the incubation period could infect others.MethodsWe collected data on demographic characteristics, exposure history, and symptom onset day of the confirmed cases, which had been announced by the Chinese local authorities. We evaluated the potential of transmission during the incubation period in 50 infection clusters, including 124 cases. All the secondary cases had a history of contact with their first-generation cases prior to symptom onset.ResultsThe estimated mean incubation period for COVID-19 was 4.9 days (95% confidence interval [CI], 4.4 to 5.4) days, ranging from 0.8 to 11.1 days (2.5th to 97.5th percentile). The observed mean and standard deviation (SD) of serial interval was 4.1±3.3 days, with the 2.5th and 97.5th percentiles at −1 and 13 days. The infectious curve showed that in 73.0% of the secondary cases, their date of getting infected was before symptom onset of the first-generation cases, particularly in the last three days of the incubation period.ConclusionsThe results indicated the transmission of COVID-9 occurs among close contacts during the incubation period, which may lead to a quarantine loophole. Strong and effective countermeasures should be implemented to prevent or mitigate asymptomatic transmission during the incubation period in populations at high risk.

ACS Style

Wei Xia; Jiaqiang Liao; Chunhui Li; Yuanyuan Li; Xi Qian; Xiaojie Sun; Hongbo Xu; Gaga Mahai; Xin Zhao; Lisha Shi; Juan Liu; Ling Yu; Meng Wang; Qianqian Wang; Asmagvl Namat; Ying Li; Jingyu Qu; Qi Liu; Xiaofang Lin; Shuting Cao; Shu Huan; Jiying Xiao; Fengyu Ruan; Hanjin Wang; Qing Xu; Xingjuan Ding; Xingjie Fang; Feng Qiu; Jiaolong Ma; Yu Zhang; Aizhen Wang; Yuling Xing; Shunqing Xu. Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole. 2020, 1 .

AMA Style

Wei Xia, Jiaqiang Liao, Chunhui Li, Yuanyuan Li, Xi Qian, Xiaojie Sun, Hongbo Xu, Gaga Mahai, Xin Zhao, Lisha Shi, Juan Liu, Ling Yu, Meng Wang, Qianqian Wang, Asmagvl Namat, Ying Li, Jingyu Qu, Qi Liu, Xiaofang Lin, Shuting Cao, Shu Huan, Jiying Xiao, Fengyu Ruan, Hanjin Wang, Qing Xu, Xingjuan Ding, Xingjie Fang, Feng Qiu, Jiaolong Ma, Yu Zhang, Aizhen Wang, Yuling Xing, Shunqing Xu. Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole. . 2020; ():1.

Chicago/Turabian Style

Wei Xia; Jiaqiang Liao; Chunhui Li; Yuanyuan Li; Xi Qian; Xiaojie Sun; Hongbo Xu; Gaga Mahai; Xin Zhao; Lisha Shi; Juan Liu; Ling Yu; Meng Wang; Qianqian Wang; Asmagvl Namat; Ying Li; Jingyu Qu; Qi Liu; Xiaofang Lin; Shuting Cao; Shu Huan; Jiying Xiao; Fengyu Ruan; Hanjin Wang; Qing Xu; Xingjuan Ding; Xingjie Fang; Feng Qiu; Jiaolong Ma; Yu Zhang; Aizhen Wang; Yuling Xing; Shunqing Xu. 2020. "Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole." , no. : 1.