⁶⁸Ga-DOTA-JR11 is a somatostatin receptor subtype 2–specific antagonist used for PET/CT imaging. The purpose of this study was to compare ⁶⁸Ga-DOTA-JR11 and ⁶⁸Ga-DOTATATE PET/CT in patients with metastatic, well-differentiated neuroendocrine tumors. Methods: Patients with histologically proven, metastatic or unresectable, well-differentiated neuroendocrine tumors were prospectively recruited to this study. Each patient received an intravenous injection of ⁶⁸Ga-DOTATATE (155 ± 52 MBq) on the first day and ⁶⁸Ga-DOTA-JR11 (148 ± 52 MBq) on the second day. Whole-body PET/CT scans were performed at 40–60 min after injection on the same scanner. Physiologic normal-organ uptake, lesion numbers, and lesion uptake were compared. Results: Thirty-one patients were prospectively enrolled in the study. The SUV_max of the spleen, renal cortex, adrenal glands, pituitary glands, stomach wall, normal liver parenchyma, small intestine, pancreas, and bone marrow was significantly lower on ⁶⁸Ga-DOTA-JR11 than on ⁶⁸Ga-DOTATATE PET/CT (P < 0.001). ⁶⁸Ga-DOTA-JR11 detected significantly more liver lesions (552 vs. 365, P = 0.001) but fewer bone lesions (158 vs. 388, P = 0.016) than ⁶⁸Ga-DOTATATE. The target-to-background ratio of liver lesions was significantly higher on ⁶⁸Ga-DOTA-JR11 (7.7 ± 5.4 vs. 3.4 ± 2.0, P < 0.001). ⁶⁸Ga-DOTA-JR11 and ⁶⁸Ga-DOTATATE PET/CT showed comparable results for primary tumors and lymph node metastases on both patient-based and lesion-based comparisons. Conclusion:⁶⁸Ga-DOTA-JR11 performs better in detecting liver metastases, with a better tumor-to-background ratio, whereas ⁶⁸Ga-DOTATATE may outperform ⁶⁸Ga-DOTA-JR11 in the detection of bone metastases. However, the lower somatostatin receptor subtype 2 affinity of ⁶⁸Ga-DOTA-JR11 than of ¹⁷⁷Lu-DOTA-JR11 may limit its role as a diagnostic pair for the theranostic approach with ¹⁷⁷Lu-DOTA-JR11.