Different roles of TGF-β in the multi-lineage differentiation of stem cells

Miao silver, generally referred to as the unique silver ornaments manufactured by the Miao ethnicity with over 400 years of history, was listed as a Chinese national intangible cultural heritage in 2006. Through primary research methods, including local investigation, interviews, and workshops at Maliao Village in Guizhou, this study found that sizeable industrial production shrank the market needs for traditional Miao silver handicrafts. A growing number of young Miao people pursue higher incomes and leave their hometowns to make a living in cities instead of engaging in Miao silver handcrafting in villages. Based on the difficulties encountered in the inheritance of Miao silver craftsmanship, this project creatively proposed a digital strategy based on the NFT digital twin application to preserve and maintain Miao silver technology in the context of the metaverse era. By conducting design experiments combining digital technology and the traditional Miao silver manufacturing techniques, a collection of NFT digital twins, digital duplications of Miao silver handicrafts that Miao silversmith jointly worked with 3D technologist, was created as a vital research outcome. The results show that this attempt is beneficial to help expand the use scenarios, extend the lifespan, and increase the commercial value of Miao silver. To sum up, taking Miao silverware handicrafts as a research case, this paper dialectically discusses the relationship between industrial manufacturing and traditional handicraft industries, making contributions to the inheritance and development of Miao silver and also putting forward innovative solutions to promote the prosperity of intangible cultural heritage worldwide.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is spreading at an alarming rate, and it has created an unprecedented health emergency threatening tens of millions of people worldwide. Previous studies have indicated that SARS-CoV-2 ribonucleic acid could be detected in the feces of patients even after smear-negative respiratory samples. However, demonstration of confirmed fecal-oral transmission has been difficult. Clinical studies have shown an incidence rate of gastrointestinal (GI) symptoms ranging from 2% to 79.1% in patients with COVID-19. They may precede or accompany respiratory symptoms. The most common GI symptoms included nausea, diarrhea, and abdominal pain. In addition, some patients also had liver injury, pancreatic damage, and even acute mesenteric ischemia/thrombosis. Although the incidence rates reported in different centers were quite different, the digestive system was the clinical component of the COVID-19 section. Studies have shown that angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, was not only expressed in the lungs, but also in the upper esophagus, small intestine, liver, and colon. The possible mechanism of GI symptoms in COVID-19 patients may include direct viral invasion into target cells, dysregulation of angiotensin-converting enzyme 2, immune-mediated tissue injury, and gut dysbiosis caused by microbiota. Additionally, numerous experiences, guidelines, recommendations, and position statements were published or released by different organizations and societies worldwide to optimize the management practice of outpatients, inpatients, and endoscopy in the era of COVID-19. In this review, based on our previous work and relevant literature, we mainly discuss potential fecal-oral transmission, GI manifestations, abdominal imaging findings, relevant pathophysiological mechanisms, and infection control and prevention measures in the time of COVID-19.

The Microbiome Protocols eBook (MPB) serves as a crucial bridge, filling gaps in microbiome protocols for both wet experiments and data analysis. The first edition, launched in 2020, featured 152 meticulously curated protocols, garnering widespread acclaim. We now extend a sincere invitation to researchers to participate in the upcoming 2nd version of MPB, contributing their valuable protocols to advance microbiome research.