Background: Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection is a major public health problem in Ethiopia. Patients with TB-HIV co-infection have significantly higher mortality rates compared to those with TB or HIV mono-infection. This systematic review and meta-analysis aim to summarize the evidence on mortality and associated factors among patients with TB-HIV co-infection in Ethiopia. Methods: Comprehensive searches were conducted in multiple electronic databases (PubMed/MEDLINE, Embase, CINAHL, Web of Science) for observational studies published between January 2000 and present, reporting mortality rates among TB/HIV co-infected individuals. Two reviewers performed study selection, data extraction, and quality assessment independently. Random-effects meta-analysis was used to pool mortality estimates, and heterogeneity was assessed using I² statistics. Subgroup analyses and meta-regression were performed to explore potential sources of heterogeneity. Results: 185 articles were retrieved with 20 studies included in the final analysis involving 8,113 participants. The pooled mortality prevalence was 16.65% (95% CI 12.57%-19.65%) with I² : 95.98% & p-value < 0.00. Factors significantly associated with increased mortality included: older age above 44 years (HR: 1.82; 95% CI: 1.31–2.52), ambulatory(HR: 1.64; 95% CI: 1.23–2.18) and bedridden functional status(HR: 2.75; 95% CI: 2.01–3.75), extra-pulmonary Tuberculosis (ETB) (HR: 2.34; 95% CI: 1.76–3.10), advanced WHO stage III (HR: 1.76; 95% CI: 1.22–2.38) and WHO stage IV (HR: 2.17; 95% CI:1.41–3.34), opportunistic infections (HR: 1.75; 95% CI: 1.30–2.34), low CD4 count of < 50 cells/mm³ (HR: 3.37; 95% CI: 2.18–5.22) and lack of co-trimoxazole prophylaxis (HR: 2.15; 95% CI: 1.73–2.65). Conclusions: TB/HIV co-infected patients in Ethiopia experience unacceptably high mortality, driven by clinical markers of advanced immunosuppression. Early screening, timely treatment initiation, optimizing preventive therapies, and comprehensive management of comorbidities are imperative to improve outcomes in this vulnerable population.

Background: The primary goal of antiretroviral therapy is to prevent human immune deficiency virus (HIV)-related morbidity and mortality. Deferring antiretroviral therapy (ART) until CD4 counts decline puts individuals with HIV at risk of HIV-related morbidity and mortality. Objective: This study aims to assess the effect of the test and treat strategy on mortality among HIV-positive clients on ART in public hospitals in Addis Ababa. Methods: A retrospective cohort study was conducted at five selected public hospitals in Addis Ababa. A cohort of 216 ART clients taken as an exposed group (test and treat” strategy) from 2017 to 2019 and 216 ART clients as an unexposed group taken from 2014 to 2017; totally, 432 clients were included in the study. Multivariate Cox regression was used to estimate the effect of the test and treat strategy on the survival of ART clients adjusting for other covariates. Results: The 432 clients contributed to a total of 1025.17 person-years follow-up. Ninety-one (21.06%) of them died, 14.3% were unexposed and 6.7% were exposed (test and treat). The incidence of death was 92.4 and 81.8/1000 person-years in the unexposed group and exposed group, respectively, with an overall mortality rate of 88.8/1000 person-years. Besides, test and treat strategy (AHR: 0.31; 95% CI: 0.19, 0.52), baseline CD4 counts > 350 cells/mm3 (AHR 0.40; 95%: CI: 0.20, 0.80), bedridden functional status (AHR 2.46; 95% CI: 1.41, 4.27), poor adherence (AHR 3.25; 95% CI: 1.410– 7.51), moderate malnutrition on last visit (AHR 2.56; 95% CI: 1.30– 5.04) and staying on original regimen (AHR 4.68; 95% CI 2.72, 8.07) were independent predictors of mortality. Conclusion: Mortality among HIV patients on treatment decreased significantly since the start of the test and treat strategy. Therefore, test and treat strategy should be strengthened in all public and private facilities throughout the country.

Background: Although there have been significant advancements in providing HIV-infected children with access to antiretroviral therapy (ART), the mortality rates have remained unacceptably high. Inadequate nutrient intake or absorption is a widespread problem in several African nations, resulting in undernutrition and anemia. However, the pooled effect of malnutrition and anemia on HIV-related death related to children receiving ART was not investigated in sub-Saharan Africa. Methods: We searched multiple electronic databases (PubMed/MEDLINE, Embase, CINAHL, and Web of Science) for observational studies published between January 1, 2010, and April 24, 2024 that reported the risk factors or effects of undernutrition and, anemia on HIV-related mortality among children. Study selection, data extraction, and quality evaluation were carried out separately by two reviewers. A meta-analysis was conducted using random effect models. Results: The review included 27 studies with a combined total of 61,796 study participants. The study findings showed that severe wasting (HR: 2.49; 95% CI: 1.87–3.30), being underweight (HR: 2.11; 95% CI: 1.64–2.72), and Anemia (HR: 2.58; 95% CI: 2.08–3.19) were highly linked to HIV-related death among children. The risk of death due to anemia was greater among children under the age of 5 years than older children. Conclusion: Undernutrition and anemia in sub-Saharan African children increased the risk of HIV-related death. The impact of malnutrition and anemia among under 5 years old children with HIV/AIDS was more pronounced, suggesting that these conditions at this early age can have more serious consequences for a child’s survival. The importance of combining nutrition with HIV treatment programs in sub-Saharan African countries is crucial.

Background: Infection with coronavirus disease (COVID-19) has become a severe public health issue worldwide. A broad amount of information related to the novel coronavirus (COVID-19) pandemic was disseminated by social media in Ethiopia. To date, there is limited evidence on the influence of social media use for covid-19 related information on covid-19 preventive practice. Therefore, this study aimed to assess the influence of social media use on the practice of COVID-19 preventive measures in Ethiopia. Methods: This study employed an anonymous internet-based online cross-sectional survey using Google forms to collects the data from the respondents from 15 May to 17 June 2020 in Ethiopia. Multivariable logistic regression was used to assess the relationship between social media usage as a predictor and COVID-19 preventive practice, after adjusting for socio-demographic and risk perception of COVID-19 variables. The data were analysed using SPSS version 21. Results: A total of 372 respondents have participated in the study. From 372, 208(55.9%) respondents in this study were male. Study participants who had good utilization of social media to get COVID-19 related information were 9.5 times engaged in COVID-19 preventive practices compared to study participants who had poor utilization of social media to get covid-19 related information (AOR= 9.59, 95% CI = 5.70 - 16.13). Also, study participants who had a high-risk perception of COVID-19 were 2.6 times engaged in COVID-19 practices compared to study participants who had a low-risk perception of covid-19 (AOR = 2.63, 95% CI = 1.58 - 4.38). Study participants who were students at the time of this study were four times more likely to show adequate COVID-19 preventive practice score compared to those who had another occupational status (AOR= 4.07, 95% CI= 1.66 - 9.98) Conclusions: Our results show that the usage of social media networks can have a positive effect on the practice of preventive measures and public safety against COVID-19; high-risk perception contributed to preventive activities against COVID-19. Social networking platforms can be used by public health agencies as an important method to raise public health understanding by disseminating concise messages to targeted audiences.

Background: Health equity has emerged as a global issue in the post-2015 Sustainable Development Goals, and Ethiopia is no exception. Despite positive improvements, inequities in maternal health service utilization among demographic groups continue to be one of Ethiopia’s significant challenges in decreasing maternal mortality. This study focuses on antenatal care service discrimination among a local poor group known as the “golden hands” community in Ethiopia’s Kembata Tembaro zone. The subgroup community consists of outcast artesian groups known as “golden hands,” formerly known as “Fuga,” who face discrimination in all aspects of life owing to their living conditions and ethnic background. Methods: A community-based comparative cross-sectional study was conducted in Ethiopia’s Kembata Tembaro, zone in the Southern Nations, Nationalities, and Peoples’ Region (SNNPR), from January to February 2022. The study focused on two groups, “golden hands” and “non-golden hands,” consisting of women aged 15–49 years. Using stratified and multistage cluster sampling, 1,210 participants were selected, with 440 from golden hand communities and 770 from non-golden hand communities. Data was collected through translated questionnaires, and data quality was rigorously monitored. The concentration curve and index, as well as logistic-based decomposition analysis, were used to examine inequality. The statistical significance threshold was set at p < 0.05 with a 95% confidence interval. Result: This study comprised 1,210 eligible participants, 440 of whom were golden hand community members. Discrimination accounted for 60.23% of the decreased antenatal care (ANC) service use by the golden hand community. Age, urban residence, and wealth index were the most important independent factors with statistically significant contributions to changes owing to differences in effects (discriminated difference). Conclusion: Since ANC service discrimination is prevalent, the government and nongovernmental organizations should take steps to ensure that marginalized groups in society, such as golden hand women, the poor, the uneducated, and rural people, have equal access to service utilization opportunities.

Background: Ethiopia is one of the developing countries hit by the double burden of malnutrition both under and over nutrition. Inappropriate food choice decisions are among the reasons for the problem, which are poorly investigated in the country, and it is concerned with providing information about the drivers of food choice decision-making process behavior that reflects the behavior of the young population, particularly in college students, which provides a window of opportunity for nutritional interventions. Therefore, this study aims to assess drivers of food choice among college students in Addis Ababa, Ethiopia. Methods and Materials: An institution-based cross-sectional study was conducted among 330 students who were selected using multistage sampling. For analysis, data were input into Epi Info version 7 and exported to STATA version 16.0. To summarize the data, descriptive measures such as frequencies, percentages, and summary measures were employed. Exploratory and confirmatory factor analyses were performed using a structural equation model to identify the driving factors of food choice. Results: Mood, health concern, sensory appeal, price, convenience, and familiarity were identified as drivers of food choice with significant factor loadings (p < 0.001) and acceptable internal consistency of items (α=0.91). However, the naturalness of the dietary composition and weight concerns have received the least attention. Conclusion: The study identified various biological, social, and economic factors that drive food choice decisions. Effective nutrition education and preventive interventions should be implemented to reduce unhealthy food decisions among college students through promoting favorable food choice decisions.