The Gangdese metallogenic belt in Tibet is an important copper and iron polymetallic, metallogenic belt in western China. The Luobuzhen epithermal Au-Ag and Hongshan porphyry Cu deposits, as two new discovery deposits in the last few years, are located in the western Gangdese metallogenic belt. In this paper, we present quartz vein Rb-Sr isochron, zircon U-Pb and molybdenite Re-Os ages for a better understanding of the minerallogenetic epoch of the deposits. Geochronological data show that the Rb-Sr isochron age of a quartz vein in a Luobuzhen Au-Ag deposit is 21.1 ± 1.8 Ma (MSWD (mean standard weighted deviation) = 0.19), zircon U-Pb ages from diorite and granodiorite porphyry in Hongshan Cu deposit are 50.0 ± 0.4 Ma (MSWD = 0.94) and 23.7 ± 0.1 Ma (MSWD = 0.73), respectively, and a Re-Os isochron age of molybdenite in Hongshan Cu deposit is 23.0 ± 2.0 Ma (MSWD = 0.014). These data suggest that the Luobuzhen epithermal Au-Ag and Hongshan porphyry Cu deposits formed at ca. 23–21 Ma, which were controlled by the same magmatic hydrothermal events. Formation of both the Luobuzhen and Hongshan deposits were obviously earlier than the Miocene porphyry metallogenetic events in the Gangdese porphyry copper belt.