Poly(lactic acid) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) blends and their composite were prepared by melt compounding. Maleic anhydride grafted PLA (PLA-g-MA) was used as a compatibilizer. With the addition of PBAT into PLA, elongation at break and impact strength increased but tensile strength and modulus decreased. Incorporating PLA-g-MA into PLA/PBAT blend improved the mechanical properties of the blend. Tensile properties of blown film prepared from the compatibilized PLA/PBAT blend were better than those of the uncompatibilized PLA/PBAT blend. Incorporating CaCO₃ resulted in increased tensile strength and modulus of the film prepared from the compatibilized blend.

Biopolymer based scaffolds are commonly considered as suitable materials for medical application. Poly(lactic acid) (PLA) is one of the most popular polymers that has been used as a bioscaffold, but it has poor cell adhesion and slowly degrades in an in vitro environment. In this study, silk fibroin (SF) was selected to improve cell adhesion and degradability of electrospun PLA. In order to fabricate a PLA/SF scaffold that offered both biological and mechanical properties, related parameters such as solution viscosity and SF content were studied. By varying the concentration and molecular weight of PLA, the solution viscosity significantly changed. The effect of solution viscosity on the fiber forming ability and fiber morphology was elucidated. In addition, commercial (l-lactide, d-lactide PLA) and medical grade PLA (pure PLLA) were both investigated. Mechanical properties, thermal properties, biodegradability, wettability, cell viability, and gene expression of electrospun PLA and PLA/SF based nanofibrous scaffolds were examined. The results demonstrated that medical grade PLA electrospun scaffolds offered superior mechanical property, degradability, and cellular induction for meniscus tissue regeneration. However, for commercial non-medical grade PLA used in this study, it was not recommended to be used for medical application because of its toxicity. With the addition of SF in PLA based scaffolds, the in vitro degradability and hydrophilicity were improved. PLAmed50:SF50 scaffold has the potential to be used as biomimetic meniscus scaffold for scaffold augmented suture based on mechanical properties, cell viability, gene expression, surface wettability, and in vitro degradation.