Several modern drugs, which are derived from traditional herbal medicine are used in contemporary pharmacotherapy. Currently, the study of drug–plant interactions in pain has increased in recent years, looking for greater efficacy of the drug and reduce side effects. The antinociception induced by intragastric co-administration of the combination of pomegranate peel extract (PoPEx) and acetylsalicylic acid (ASA) was assessed using the isobolographic analysis in formalin test (nociceptive and inflammatory pain). The effective dose that produced 30% of antinociception (ED₃₀) was calculated for both drugs from the logarithmic dose–response curves, subsequently generating a curve with the combination on fixed proportions (1:1) of PoPEx and ASA. Through isobolographic analysis, this experimental ED₃₀ was compared with the calculated theoretical additive ED₃₀. The result was a synergistic interaction, the experimental ED₃₀ was significantly smaller (p < 0.05) than the theoretical ED₃₀. The antinociceptive mechanism of the PoPEx-ASA combination involves the l-Arginine/NO/cGMP pathway, antioxidant capacity, and high content of total phenols. These findings suggest that an interaction between PoPEx and ASA could be a novel treatment for inflammatory and nociceptive pain, also diminish the secondary reactions of ASA.

Coronavirus disease 2019 (COVID-19) can directly or indirectly affect the central and peripheral nervous systems, resulting in cognitive impairment, memory problems, and a wide range of neuromuscular involvement, including neuropathies. However, the long-term neurological complications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are not clear. The aim this study was to analyze a case report the presence of neurological sequelae due to post-Coronavirus disease 19 in a patient without apparent previous neurological symptoms. Clinical case: A 46-year-old patient, with no relevant history for the described condition, who, after severe COVID-19 infection, started a mixed neuropathy and mental fog syndrome as the main sequel. Multiple laboratory and imaging studies were performed during and after his hospital stay, and it was corroborated by an electromyography that it occurred from a neuropathy triggered by COVID-19 infection. Conclusions: This case provides additional evidence that mixed neuropathy and brain fog syndrome are potential complications of post-coronavirus disease 2019 syndrome. The neurological sequelae that manifest after a COVID-19 episode can be rapidly enhanced as a consequence of another alteration in some systems of the organism. However, future studies are necessary to elucidate the incidence of these neurological complications, their pathophysiological mechanisms and their therapeutic options.

This narrative case study portrays a young woman’s life experience and adjustment process after suffering a traumatic spinal cord injury (SCI) 5 years ago. It is analyzed retrospectively from the perspective of the middle-range theory (MRT) of adapting to chronic health conditions by Buckner and Hayden (2014), and Ricoeur’s narrative philosophy is expanded. Understanding Alice’s narrative from this perspective allows us to understand the process of adaptation to a condition of disability due to a spinal cord injury, from the perspective of a nurse who was forced to change her role as a caregiver to a role of being cared for, due to the changes in her body and her corporality due to the consequences of the injury. In this narrative, the focal and contextual stimuli, the coping processes with special emphasis on the intrinsic and extrinsic adaptive processes, and the results of the process are identified.

Se comparó el uso de las pruebas de Papanicolaou y de VPH en trabajadoras de facultades del área de la salud de una universidad pública de México. Se determinó el nivel de uso de las pruebas utilizando una encuesta dividida en 3 dimensiones: conocimientos sobre las pruebas, la frecuencia de uso y la conformidad; se estructuró una escala ordinal en función al porcentaje de aciertos. Para el análisis estadístico se aplicó la prueba de ANOVA y chi cuadrada. Las participantes con postdoctorado muestran un mejor nivel de uso (p= 18.53) así como las docentes (p= 17.36) y aquellas que cuentan con seguro privado. Las trabajadoras de la Facultad de Enfermería y Nutrición muestran un mejor uso general de las pruebas (media= 16.97) y tienen mayor conocimiento, así como nivel de conformidad. La formación profesional es importante para la adquisición de información útil para el cuidado de la salud.

Introducción: La Lesión de la Médula Espinal (LME) implica secuelas graves y significativas que impactan en la calidad de vida de la persona a causa del dolor neuropático y los problemas de sueño. Objetivo: Describir la relación entre la calidad del sueño y el dolor neuropático en personas con Lesión de la Médula Espinal. Metodología: Estudio descriptivo, correlacional basado en pacientes diagnosticados con Lesión de la Médula Espinal utilizando la escala S-LANSS para identificar la presencia de dolor neuropático y el Cuestionario de Pittsburgh para evaluar la calidad del sueño. Para analizar estadísticamente los datos, se utilizó el software SPSS v25. Resultados: Se evaluaron 24 participantes, los resultados muestran una prevalencia mayor en mujeres y en el rango etario de 41 a 50 años (46%), con afectaciones predominantes en las vértebras torácicas (47.8%). La mayoría de los pacientes presentan una lesión completa con pérdida del movimiento y sensación por debajo de la lesión (ASIA-A). En nuestro caso, la causa principal de la lesión fueron las caídas (42%). En el análisis de los datos utilizando SPSS se observó resultados no significativos (p=0.092), indicando la ausencia de una correlación entre las variables. Conclusiones: Al observarse que no existe correlación significativa, se propone una exploración que sugiera más opciones para investigaciones futuras.