Alexandru Plesoianu

Mr. Alexandru Plesoianu

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Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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6 May 2022 in Bioengineering
Verified
Journal Article
Open access
PDF file
APAlexandru Plesoianu
Alexandru Plesoianu
Carmen Elena PleșoianuCarmen Elena Pleșoianu
Carmen Elena Pleșoianu
Iris Bararu BojanIris Bararu Bojan
Iris Bararu Bojan
ABAndrei Bojan
Andrei Bojan
ATAndrei Tarus
Andrei Tarus
GTGrigore Tinica
Grigore Tinica
Despite evidence associating the use of mechanical circulatory support (MCS) devices with increased survival and quality of life in patients with advanced heart failure (HF), significant complications and high costs limit their clinical use. We aimed to design an innovative MCS device to address three important needs: low cost, minimally invasive implantation techniques, and low risk of infection. We used mathematical modeling to calculate the pump characteristics to deliver variable flows at different pump diameters, turbomachinery design software CFturbo (2020 R2.4 CFturbo GmbH, Dresden, Germany) to create the conceptual design of the pump, computational fluid dynamics analysis with Solidworks Flow Simulation to in silico test pump performance, Solidworks (Dassault Systèmes SolidWorks Corporation, Waltham, MA, USA) to further refine the design, 3D printing with polycarbonate filament for the initial prototype, and a stereolithography printer (Form 2, Formlabs, Somerville, MA, USA) for the second variant materialization. We present the concept, design, and early prototyping of a low-cost, minimally invasive, fully implantable in a subcutaneous pocket MCS device for long-term use and partial support in patients with advanced HF which unloads the left heart into the arterial system containing a rim-driven, hubless axial-flow pump and the wireless transmission of energy. We describe a low-cost, fully implantable, low-invasive, wireless power transmission left ventricular assist device that has the potential to address patients with advanced HF with higher impact, especially in developing countries. In vitro testing will provide input for further optimization of the device before proceeding to a completely functional prototype that can be implanted in animals.

8 January 2016
Verified
Book Chapter
Closed access
PDF file
APAlexandru Plesoianu
Alexandru Plesoianu
Carmen Elena PleșoianuCarmen Elena Pleșoianu
Carmen Elena Pleșoianu
CALIN CORCIOVACALIN CORCIOVA
CALIN CORCIOVA
GTGrigore Tinica
Grigore Tinica