Background: Thailand’s logistics costs significantly exceed global averages. This study examines the novel application of a triple-helix model in factory logistics improvement projects in Northern Thailand from 2022 to 2024, addressing industrial logistics inefficiencies. Methods: The project involved 30 factories across various sectors, employing a case study methodology to analyze improvement initiatives in transportation, warehouse/inventory management, and logistics administration. Results: Transportation management interventions yielded up to 25% cost savings and improved delivery performance. Warehouse and inventory management upgrades led to inventory cost reductions of up to 55%. Logistics administrative improvements resulted in up to 20% cost savings and enhanced planning capabilities. Conclusions: The project demonstrates the effectiveness of the triple-helix model in facilitating knowledge transfer and practical improvements in industrial logistics. These findings are valuable for Thai industries, policymakers, and logistics managers globally, offering a blueprint for similar initiatives in developing economies. The success of this approach provides practical insights for optimizing logistics operations, potentially benefiting supply chain stakeholders, economic planners, and researchers seeking to enhance logistics efficiency and reduce costs in various industrial contexts.