To study the mechanical deformation characteristics and anti-explosion mechanisms of steel-structure protective doors under chemical explosion shock wave loads, numerical simulations of loads and door damage were carried out using the AUTODYN and LS-DYNA software based on model tuning with actual field test results. The finite element simulation results were compared with the test results to verify the accuracy of the simulation model and material parameters. A parametric analysis was carried out on the influencing factors of the anti-explosion performance of the beam–plate steel structure protective door under typical shock wave loads. The impact of the material strength and geometry of each part of the protective door on its anti-explosion performance was studied. The results showed that the protective door sustained a uniform shock wave load and that increasing the steel strength of the skeleton could significantly reduce the maximum response displacement of the protective door. The steel strength increase of the inner and outer panels had little or a negligible effect on the anti-explosion performance of the protective door. The geometric dimensions of different parts of the protective door had different effects on the anti-explosion performance. Increasing the skeleton height had the most significant effect on the anti-explosion performance. The skeleton’s I-steel flange thickness and the inner and outer panel thicknesses had less significant effects.