There is a problem among Generation Z regarding the insufficient perception of green apparel consumption and the “perception–action paradox”, which presents a great challenge to China’s future sustainable development. To address this problem, we constructed a chain multiple mediation research framework that explored the transmission paths between the environmental value and green consumption behavior of apparel, as well as the associated influence mechanisms; this was performed by integrating environmental responsibility and green consumption intention. Data for this study were collected through a multistage sampling survey of 657 Chinese Gen Z members born between 1995 and 2002. Our results reveal that all three types (egoism, altruism, and biospheric values) of environmental values had different direct and indirect effects on the green apparel consumption behavior for Gen Z members, but the indirect effects of each aspect significantly outweighed their direct effects. In terms of the direct effects, egoistic values had no significant direct negative effect on green apparelconsumption behavior, whereas the significant positive direct effect of the biospheric values was greater than that of altruistic values. The greatest mediating effect between the environmental values and green apparelconsumption behaviorwas green consumption intention, followed by environmental responsibility, and ending with the chain mediation effect of environmental responsibilityand green consumption intention. These findings suggest that it is imperative to stress the cultivation of green consumption intentions, environmental responsibility, and environmental values and bridge the seamless link among these variables for the promotion of green apparel consumption practices in Generation Z. This is the first study that explicitly identifies the significant chain mediating effect of environmental responsibility and green consumption intention between the environmental values and green apparel consumption behavior. Our findings broaden the theoretical research perspective of green apparel consumption behavior and provide a reference for the guiding of green consumption practices and policy formulation for the global population of Generation Z.

To deal with the challenges posed by generational differences in China’s sustainable consumption transition, this study’s pioneers using a mixed-methods approach with data mining and literature research to classify Chinese residents into four generations based on the sustainable consumption perspective. We developed a conceptual model of generational differences and conducted an empirical study using structured interviews with a multi-stage random sampling approach. The results highlight significant differences and distinct influencing mechanisms among the four generations regarding perceptions of sustainable consumption, lifestyle, and sustainable consumption behavior. Based on this, multi-generational differentiated green marketing strategies, green product development and green marketing practices, as well as consumer education systems and strategies for stakeholders including the government, enterprises, and society are proposed. The findings contribute to advancing theoretical perspectives in sustainable consumption research, serving as a valuable reference for sustainable consumption research worldwide.

There exists a problem of insufficient perception of sustainable consumption and the “perception–action paradox” among Chinese urban residents. To address this problem, we construct a holistic research framework, integrating micro and macro levels based on the “Social Practice Approach”, with lifestyle as the mediating variable and supply conditions as the moderating variable. This study aims to reveal the relationship between the sustainable consumption perception and efficiency behaviors of Chinese urban residents, as well as the associated influence mechanisms. Our results show that a sustainable consumption perception exerts a significantly positive influence on four dimensions of lifestyle and efficiency behaviors. Significant differences are explicitly identified among the four dimensions of lifestyle on efficiency behavior, and the mediating effect between sustainable consumption perception and efficiency behaviors, especially the development concern and price concern. Product sustainability perception and product facility availability conditions significantly positively moderate the relationship between sustainable consumption perception and efficiency behavior. Exploring the four dimensions of lifestyle and their deep-seated mediation effect on efficiency behavior will broaden the theoretical perspective of efficiency behavior research and guide sustainable consumption practices in China.

Multidrug resistance (MDR) is an important issue in current cancer treatments. In human cancer, drug resistance is primarily associated with the overexpression of multidrug resistance gene 1 (MDR1). Therefore, the human MDR1 gene promoter may be a target for anti‑MDR drug screening. Numerous methods to prevent MDR have been investigated. However, they have been proven to be clinically ineffective. Therefore, the aim of the present study was to investigate whether downregulation of nucleophosmin (NPM) demonstrates any effects on the reversal of MDR in hepatocellular carcinoma (HCC) cells. In the present study, two in vitro MDR HCC cell lines, HepG2/Adriamycin (ADM) and SMMC7721/ADM, were established and the level of MDR was measured. The results demonstrated that NPM downregulation markedly reversed the effects of MDR in the model used. In addition, NPM downregulation reduced P-glycoprotein expression, as well as MDR1 expression. These results suggested that downregulation of NPM may be a novel and effective method of reversing the effects of MDR, and may be a potential adjuvant for tumor chemotherapy.

Aims: To detect microsatellite loci alterations by fluorescent multiplex PCR in urine sediment cell of urothelial carcinoma, and to determine if they can be used as genetic markers for diagnosis of urothelial carcinoma. Materials and Methods: Microsatellite alteration analysis was conducted using fluorescent multiplex PCR with samples from 64 cases of urothelial carcinomas of the bladder. Three microsatellites spanning the 3p14 and two additional microsatellites in 9q33 and 9p22 were analyzed. Microsatellite alterations (microsatellite instability and/or loss of heterozygosity) in urine sediment cells of urothelial carcinoma patients matched for peripheral blood and tumor tissue were all analyzed. Results: The frequency of microsatellite alterations in urothelial carcinoma was chromosome 3p (D3S1234: 14.6% (7/48), D3S1300: 16.7% (8/48), D3S1313: 8.35% (4/48)); 9q (D9S242: 33.3% (16/48)), and 9p (D9S162: 27.1% (13/48)). Microsatellite alterations happened in 62.5% (40/64) of the patients when combined with all five markers. Our study showed a significant correlation between the microsatellite alteration of the five-locus panel and recurrence (p = 0.010) and smoking habit (p = 0.006). Conclusions: The results suggest that these microsatellite loci alterations may have an important role in the recurrence of urothelial carcinomas. Further studies are needed to better determine the effect of microsatellite loci alterations on prognosis.