The aim of this study was to determine if the quantity of running load performed in pre-season affects the incidence of injury in elite Gaelic footballers. It was hypothesized that a greater quantity of running loads completed will reduce the incidence rate of injury. A cohort of elite male Gaelic football players (n = 25) was prospectively monitored throughout one full season. This longitudinal study involved the collection of GPS data and injury data. Participants were retrospectively divided into two groups and assigned to a high (HTL, completed >50% of pre-season sessions, n = 13) or low (LTL, completed 6.4 m/s) and high-intensity running meters (high-speed running meters and sprint meters combined) were collected during all sessions. A one-way analysis of variance (ANOVA) was completed to understand the variation of external training load data across the different phases of the season. A series of repeated measures of ANOVA were subsequently completed to understand the variation of external training load data across seasonal phases within the training groups. Although the LTL group had a higher incidence rate of non-contact injuries (large effect size) per 1000 h of exposure in each phase of the season, statistical analysis revealed that there was no significant difference (F = 4.32, p = 0.173, partial η² = 0.684, large) between the HTL (14.9 ± 4.17/1000 h) and the LTL (24.5 ± 7.36/1000 h) groups. Additionally, the HTL group was able to sustain greater running loads in the competitive phases of the season compared to the LTL group, total distance (F = 8.10, p < 0.001, partial η² = 0.299, large), high-speed running distance (F = 8.74, p < 0.001, partial η² = 0.304, large) and high-intensity running distance (F = 7.63, p < 0.001, partial η² = 0.276, large). Furthermore, players who complete a greater proportion of running loads in pre-season may alter their body composition levels to more optimal levels, which in turn may reduce the risk of injury while also helping increase or maintain performance-related fitness markers such as aerobic fitness.