Recent studies showed a high frequency of low bone mineral density (BMD) in HIV-infected patients and no reports have been issued in Turkey. Our aim was to evaluate BMD and risk factors for osteopenia/osteoporosis in HIV-infected patients that attended an outpatient clinic in Istanbul, Turkey. In order to determine the prevalence of BMD, 126 HIV-infected patients had been studied with dual energy X-ray absorptiometry (DEXA). The association between BMD and age, gender, body mass index (BMI), habits, 25(OH)vitamin D, HIV RNA, CD4 lymphocyte nadir, using and duration of highly active antiretroviral treatment (HAART) were investigated by using multivariate analysis. Median age was 40.1 years (range, 20-70); 84% were male; 35.7% patients had AIDS, 63.5% were treated with HAART. Osteopenia and osteoporosis were diagnosed in 53.9% and 23.8%, respectively. Mean plasma HIV RNA was 5.2 (SD 1.0) log10 copies/mL and CD4 lymphocyte nadir was 313.8 (SD 226.2)/mm(3). Factors associated with bone loss were high viral load (p=0.034), using (p=0.033) and duration of HAART (p=0.008). No correlation had been seen between sex and osteopenia/osteoporosis (p=0.794). However, males showed higher rates of osteoporosis than females (p=0.042). Our results show a very high prevalence of bone mass reduction in Turkish HIV-infected patients. This study supports the importance of both HIV and antiretroviral therapy in low BMD.

Salt stress is a major problem worldwide because it decreases yields of many important agricultural crops. Silicon is the second-most abundant element in soil and has numerous beneficial effects on plants, particularly in alleviating stress-related impacts. Pepper is an important crop in the Mediterranean region, but pepper varieties differ in their salinity tolerances. The objective of this research was to test the ability of silicon to mitigate effects of salt stress in both salt-sensitive and salt-tolerant cultivars. Salt damage was evaluated by measuring biomass, photosynthetic-related variables, leaf water potential, and membrane damage. We found that the addition of silicon solute to a growth medium was highly effective in improving plant growth by enhancing photosynthesis, stomatal conductance ( g _S ), leaf water status, and membrane stability, which in turn led to higher biomass production in salt-stressed pepper plants, especially in a salt-sensitive cultivar. From an agronomic viewpoint, application of Si may provide economically relevant productivity improvements for salt-sensitive pepper genotypes grown under moderate salinity conditions and for salt-tolerant genotype grown under higher-salinity conditions.

We present the interim results of the efficacy, immunogenicity, and safety of the two-dose schedules of TURKOVAC versus CoronaVac. This was a randomized, observer-blinded, non-inferiority trial (NCT04942405). Volunteers were 18–55 years old and randomized at a 1:1 ratio to receive either TURKOVAC or CoronaVac at Day 0 and Day 28, both of which are 3 μg/0.5 mL of inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) adsorbed to aluminum hydroxide. The primary efficacy outcome was the prevention of polymerase chain reaction (PCR)-confirmed symptomatic coronavirus disease 2019 (COVID-19) at least 14 days after the second dose in the modified per-protocol (mPP) group. Safety analyses were performed in the modified intention-to-treat (mITT) group. Between 22 June 2021 and 7 January 2022, 1290 participants were randomized. The mITT group consisted of 915 participants, and the mPP group consisted of 732 participants. During a median follow-up of 90 (IQR 86–90) days, the relative risk reduction with TURKOVAC compared to CoronaVac was 41.03% (95% CI 12.95–60.06) for preventing PCR-confirmed symptomatic COVID-19. The incidences of adverse events (AEs) overall were 58.8% in TURKOVAC and 49.7% in CoronaVac arms (p = 0.006), with no fatalities or grade four AEs. TURKOVAC was non-inferior to CoronaVac in terms of efficacy and demonstrated a good safety and tolerability profile.

All living organisms perceive mechanical signals, regardless of their taxonomic classifications or life habits. Because of their immobility, plants are influenced by a variety of environmental stresses, such as mechanical stress, during their growth and development. Plants develop physiological behaviors to adapt to their environment for long-term development and evolution. Sound-induced stress—an abiotic stress factor—is an example of mechanical stress and is caused by sound waves generated by different sources. This stress has a negative effect on the development and growth of plants. The strawberry plants evaluated in this study were exposed to three different sound intensity levels (95, 100, 105 dB) at a constant frequency of 1000 Hz. In strawberry plants, stress induced by sound waves is thought to trigger increased production of secondary metabolites as a defense mechanism. To determine the effect of sound applications, the fresh and dry weights of the roots and shoots were measured in strawberry plants, and the pH, total soluble solids (Brix), titratable acidity, vitamin C, total sugar, total acid, and total phenols were analyzed in the fruits. Results show that the sound stress, which was produced at a constant frequency (1000 Hz) and different sound levels (95, 100, 105 dB), affects the growth parameters of the plant and several quality parameters of the fruit.