The emergence of the novel SARS-CoV2 virus, proclaimed by the World Health Organization (WHO) as a culpable agent for the pandemic situation, caught the scientific and medical communities off guard. One of the most common complications following pulmonary disease is represented by gastrointestinal (GI) disorders, especially ischemic damage. Inflammation, vasculopathy, immobility, endothelial dysfunction, and a hypercoagulable condition have all been proposed as pathophysiological factors for GI ischemia in these patients. Owing to the COVID-19 effect on a variety of GI conditions, especially ischemic changes, and the high mortality rate, physicians should always keep in mind this complication. They should take a deeper look at clinical and imaging modalities in this cohort of patients so that a proper and time-saving treatment strategy can be applied. Our study aimed to elucidate the thrombogenic mechanism in different GI disorders. Moreover, we analyzed the factors related to necrotic GI changes, by summarizing the already reported data of GI ischemia in COVID-19. To the best of our knowledge, this review is the first to incorporate all GI ischemia cases reported in the literature so far.

Buschke–Lowenstein tumour (giant condyloma acuminatum) is a rare sexually transmitted lesion associated with human papillomavirus infection, most commonly types 6 and 11. Although histologically benign, it demonstrates locally aggressive growth, high recurrence rates, and potential malignant transformation. We report two cases of large circumferential Buschke–Lowenstein tumours involving the anorectal region. Both patients presented with progressively enlarging exophytic lesions requiring surgical management. Wide local excision was performed in both cases, followed by reconstruction with bilateral V-Y advancement flaps due to extensive tissue defects. Histopathological examination confirmed giant condyloma acuminatum without evidence of dysplasia or invasive carcinoma. Postoperative recovery was uneventful and no early recurrence was observed during follow-up. These cases highlight the importance of complete surgical excision with adequate margins and appropriate reconstructive techniques in the management of extensive perianal Buschke–Lowenstein tumours.

Background and importance: Crohn’s disease frequently requires surgical intervention due to strictures and bowel obstruction, yet postoperative recurrence remains common. Anastomotic stenosis represents a significant cause of re-intervention. Presentation of case: We present a 32-year-old man with Crohn’s disease who developed a symptomatic ileocolic anastomotic stricture 8 months after ileocecal resection. Endoscopic evaluation and computed tomography confirmed critical stenosis. Two endoscopic balloon dilations provided only temporary relief. Redo resection with Kono-S anastomosis was performed, with resection of approximately 20 cm of bowel. Clinical discussion: The Kono-S anastomosis is a hand-sewn antimesenteric technique designed to preserve luminal caliber and reduce recurrence by limiting mesenteric influence. It may be a useful option in redo surgery following a failed conventional stapled anastomosis, particularly in complex recurrent cases. Conclusion: This case sheds light on the technical feasibility of the Kono-S anastomosis in managing recurrent ileocolic anastomotic stricture in Crohn’s disease. However, as this is a single-case report, further evidence is needed to confirm its long-term safety and efficacy.

Colorectal cancer (CRC) is the third most common cancer globally, with 20%-25% of patients diagnosed at stage IV, significantly affecting overall survival (OS). Only 14% of stage IV patients survive for 5 years with palliative chemotherapy. However, the role of liver transplantation (LT) in the management of CRC liver metastasis (CRCLM) is an evolving area of interest. Recent advancements in oncologic outcomes and clinical understanding have prompted the re-evaluation of LT as a viable treatment option for CRCLM. A promising result from some prospective pilot studies reported a 5-year OS rate of 60% after LT for patients with CRCLM. Key factors influencing eligibility include tumor biology, absence of extrahepatic disease, and the patient's performance status. By synthesizing the latest research findings, we aim to provide a comprehensive overview that summarizes the most relevant data related to the clinical outcomes of patients who underwent LT for CRCLM. We aim to provide a comprehensive overview by synthesizing the latest research findings. This review discusses the inclusion criteria and eligibility for LT in CRCLM, which are of great importance to patient outcomes.

Acute appendicitis (AA) is the most frequent emergency surgical condition globally, requiring early diagnosis and surgical intervention. In immunocompromised individuals, such as transplant recipients on immunosuppressive treatment, the disease can present with an unusual signs and symptoms, which can result in diagnostic delays and an increased risk of complications. We report the case of a 54-year-old male patient who has undergone orthotopic liver transplantation (OLT) and is currently on Tacrolimus therapy. The patient presented nonspecific abdominal symptoms, absence of fever, and increased inflammatory markers. Imaging studies verified acute appendicitis along with localized peritonitis. A laparoscopic appendectomy had been performed, followed by an uneventful postoperative course. Histopathology verified phlegmonous appendicitis along with fibrino-purulent periappendicitis. This case highlights the necessity of advanced clinical attention, prompt diagnostic imaging, and a laparoscopic approach in immunocompromised individuals.