Their scientific interest is focused on structural and functional studies of proteins of biomedical interest: a) structural and functional studies of painless Nerve Growth Factor mutants; b) structural and functional studies of proneurotrophins; c) structural and functional studies on matrix proteins associated with genetic diseases; d) structural studies of microbial enzymes and transcription factors involved in Nontuberculous mycobacteria and Pseudomonas aeruginosa pathogenesis and the development of novel antimicrobics targeting this class of pathogens. Expertise: molecular biology, structural and functional biology; protein expression and purification; protein crystallization; computational biocrystallography; SAXS; bioinformatics; protein biophysical and biochemical characterization (CD, DLS, DSF, and fluorescence); intermolecular interactions (SPR, GCI, DSF, fluorescence, and ELISA), molecular modeling, and graphics; molecular mechanics; molecular dynamics. Web page: https://www.ic.cnr.it/staff/covaceuszach-sonia/