Background: The prognosis of breast cancer is often unfavorable, emphasizing the need for early metastasis risk detection and accurate treatment predictions. This study aimed to develop a novel multi-modal deep learning model using preoperative data to predict disease-free survival (DFS). Methods: We retrospectively collected pathology imaging, molecular and clinical data from The Cancer Genome Atlas and one independent institution in China. We developed a novel Deep Learning Clinical Medicine Based Pathological Gene Multi-modal (DeepClinMed-PGM) model for DFS prediction, integrating clinicopathological data with molecular insights. The patients included the training cohort (n = 741), internal validation cohort (n = 184), and external testing cohort (n = 95). Result: Integrating multi-modal data into the DeepClinMed-PGM model significantly improved area under the receiver operating characteristic curve (AUC) values. In the training cohort, AUC values for 1-, 3-, and 5-year DFS predictions increased to 0.979, 0.957, and 0.871, while in the external testing cohort, the values reached 0.851, 0.878, and 0.938 for 1-, 2-, and 3-year DFS predictions, respectively. The DeepClinMed-PGM's robust discriminative capabilities were consistently evident across various cohorts, including the training cohort [hazard ratio (HR) 0.027, 95% confidence interval (CI) 0.0016–0.046, P < 0.0001], the internal validation cohort (HR 0.117, 95% CI 0.041–0.334, P < 0.0001), and the external cohort (HR 0.061, 95% CI 0.017–0.218, P < 0.0001). Additionally, the DeepClinMed-PGM model demonstrated C-index values of 0.925, 0.823, and 0.864 within the three cohorts, respectively. Conclusion: This study introduces an approach to breast cancer prognosis, integrating imaging and molecular and clinical data for enhanced predictive accuracy, offering promise for personalized treatment strategies.

Link prediction (LP) is fundamental to graph-based applications, yet existing graph autoencoders (GAEs) and variational GAEs (VGAEs) often struggle with intrinsic graph properties, particularly the presence of negative eigenvalues in adjacency matrices, which limits their adaptability and predictive performance. To address this limitation, we propose Hyperspherical Kolmogorov–Arnold Networks for LP (HKANLP), a novel framework that combines multiple graph neural network (GNN)-based representation learning strategies with Kolmogorov–Arnold networks (KANs) in a hyperspherical embedding space. Specifically, our model leverages the von Mises–Fisher (vMF) distribution to impose geometric consistency in the latent space and employs KANs as universal function approximators to reconstruct adjacency matrices, thereby mitigating the impact of negative eigenvalues and enhancing spectral diversity. Extensive experiments on homophilous, heterophilous, and large-scale graph datasets demonstrate that HKANLP achieves superior LP performance and robustness compared to state-of-the-art baselines. Furthermore, visualization analyses illustrate the model’s effectiveness in capturing complex structural patterns. The source code of our model is publicly available at https://github.com/zxj8806/HKANLP/

In China, patients usually determine their medical specialty before they register the corresponding specialists in the hospitals. This process usually requires a lot of medical knowledge for the patients. As a result, many patients do not register the correct specialty for the first time if they do not receive help from the hospitals. In this study, we try to automatically direct the patients to the appropriate specialty based on the symptoms they described. As far as we know, this is the first study to solve the problem. We propose a neural network-based model based on a hybrid model integrated with an attention mechanism. To prove the actual effect of this hybrid model, we utilized a data set of more than 40,000 items, including eight departments, such as Otorhinolaryngology, Pediatrics, and other common departments. The experiment results show that the hybrid model achieves more than 93.5% accuracy and has a high generalization capacity, which is superior to traditional classification models.