Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, when associated with a lipid nanoemulsion in an experimental pulmonary inflammatory model. Pulmonary fibrosis is a disease associated with excessive extracellular matrix deposition. We determined to investigate the morphophysiological mechanisms in mice that were pretreated after induction with bleomycin (BLM). The pretreatment was for 21 days with saline solution, sunflower oil (SO), fish oil (FO), and fish oil nanoemulsion (NEW3). The animals received a daily dose of 50 mg/Kg of docosahexaenoic acid DHA and 10 mg/Kg eicosapentaenoic (EPA) (100 mg/Kg), represented by a daily dose of 40 µL of NEW3. The blank group was treated with the same amount daily (40 µL) during the 21 days of pretreatment. The animals were treated with SO and FO, 100 mg/Kg (containing 58 mg/Kg of polyunsaturated fats/higher% linoleic acid) and 100 mg/Kg (50 mg/Kg of DHA and 10 mg/Kg EPA), respectively. A single dose of 5 mg/mL (50 μL) bleomycin sulfate, by the intratracheal surgical method in BALB/cAnNTac (BALB/c). NEW3 significantly reduced fibrotic progression, which can be evidenced by the protection from loss of body mass, increase in respiratory incursions per minute, decreased spacing of alveolar septa, decreased severity of fibrosis, and changes in the respiratory system. NEW3 attenuated the inflammatory changes developed in the experimental model of pulmonary fibrosis, while group SO showed a significant increase in inflammatory changes. This concluded that the presented results demonstrated that is possible to positively modulate the immune and inflamamtory response to an external agressor, by changing the nutitional intake of specific fatty acids, such as omega-3 placed in fish oil. Moreover, these benefits can be improved by the nanoencapsulation of fish oil in lipid nanoemulsions.

A new coronavirus, identified in Wuhan, China, has spread globally, infecting millions of people and causing significant morbidity and mortality. The pandemic state, declared by the World Health Organization on March 11, 2020, transformed the world and made people adapt to social distance to control the spread of the virus. The race against time in search of therapeutic solutions has become essential, and nanotechnology may be able to make vaccines available in record time to stimulate the immunization of individuals. Since the beginning of 2020, scientists and companies are rapidly advancing to make vaccine candidates available at a different rate compared to other pandemics that have existed. This review briefly presents the pros and cons of the third generation vaccines, Moderna / NIAID and Pfizer - BioNTech, which are in phase 3 tests, based on lipid RNA nanoparticles. Great collaborative efforts are being invested so that soon the world population will receive doses of vaccines with proven efficacy and enable increased survival, since the pandemic has already caused many irreversible losses.

Aim: Breast cancer and its metastases involve high mortality even with advances in chemotherapy. Solid lipid nanoparticles provide a platform for drug delivery, reducing side effects and treatment-induced bone loss. A solid nanoparticle containing doxorubicin was evaluated for its ability to prevent bone loss in a pre-clinical breast cancer model. Methods: We investigated the effects of SLNDox in an aggressive metastatic stage IV breast cancer model, which has some important features that are interesting for bone loss investigation. This study evaluates bone loss prevention potential from solid lipid nanoparticles containing doxorubicin breast cancer treatment, an evaluation of the attenuation of morphological changes in bone tissue caused by the treatment and the disease and an assessment of bone loss imaging using computed tomography and electron microscopy. Results: Chemotherapy-induced bone loss was also observed in tumor-free animals; a solid lipid nanoparticle containing doxorubicin prevented damage to the growth plate and to compact and cancellous bones in the femur of tumor-bearing and healthy animals. Conclusion: The association of solid lipid nanoparticles with chemotherapeutic drugs with proven efficacy promotes the prevention of serious consequences of chemotherapy, reducing tumor progression, increasing quality of life and improving prognosis and survival.

Objetivo: analisar os recentes estudos com a hidroxicloroquina no tratamento da COVID-19. Métodos: comunicação breve relatando os principais resultados com o uso da hidroxicloroquina em ensaios clínicos e o panorama mundial desses estudos. Resultados: a maioria dos ensaios clínicos no mundo é com a hidroxicloroquina, e os resultados com o seu uso são variados. Conclusão: é urgente avaliar melhor a eficácia da hidroxicloroquina no possível tratamento da COVID-19 em pacientes não severos.

Analisar como o enfermeiro (obstetra) pode oferecer uma assistência às gestantes com complicações da síndrome hipertensiva gestacional. Trata-se de uma revisão de literatura integrativa baseada na pesquisa bibliográfica. Foi realizada por meio do levantamento do acervo de publicações, no período de 2008 a 2018, em obras, artigos científicos e páginas eletrônicas. Entende-se que os profissionais de enfermagem devem, por meio das consultas de pré-natal, estabelecer um vínculo e ambiente propício para que a gestante se sinta confortável em sanar suas dúvidas e dialogar sobre suas necessidades e aflições. Essa é uma maneira do enfermeiro conseguir viabilizar as situações de desequilíbrio emocional e identificar possíveis patologias que podem advir. A melhor conduta está nas orientações e diálogos entre o enfermeiro e cliente, porque quando há o vínculo entre ambos é possível analisar o comportamento e as necessidades reais da gestante, humanizando o cuidado e fazendo a enfermagem ter um papel de promotora da saúde.

3D printing, also known as additive manufacturing, is a technology that has existed since the 1980s. 3D printing can be applied to health in several ways: production of didactic material in the area of health, prostheses, surgical planning and with bioprinting of organs. There are several methodologies used for 3D printing applied to health, but basically they follow the process: idealization of the model, conversion of the file into STL, then G-Code and then printing and treatment of the printed object. The printers can use plastic, biodegradable material, powders, liquid or even living cells. The objective of this study is to show in a simplified way how 3D printing can be applied to health, addressing the main concepts of 3D printing. To carry out the article, a search was made for scientific articles from 2010-2023 with the theme 3D printing applied to health. This study showed that, since the 1980s, 3D printing has improved a lot, but challenges such as costs, production time and regulatory mechanisms still need to be overcome.