Paolo Lombardi

Dr. Paolo Lombardi

Naxospharma Ltd
orcid

Research Focus & Metrics

Academic Career Length

51Years (1976-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2012 in Biochemical Pharmacology
Verified
Journal Article
Closed access
MTMicol Tillhon
Micol Tillhon
LOLuis M. Guamán Ortiz
Luis M. Guamán Ortiz
Paolo LombardiPaolo Lombardi
Paolo Lombardi
ASAnna Ivana Scovassi
Anna Ivana Scovassi

15 August 2014 in Molecules
Verified
Journal Article
Open access
PDF file
LOLuis Miguel Guamán Ortiz
Luis Miguel Guamán Ortiz
Paolo LombardiPaolo Lombardi
Paolo Lombardi
MTMicol Tillhon
Micol Tillhon
ASAnna Ivana Scovassi
Anna Ivana Scovassi
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated.

12 June 2017 in Aging
Verified
Journal Article
Open access
JMJames A. McCubrey
James A. McCubrey
KLKvin Lertpiriyapong
Kvin Lertpiriyapong
LSLinda S. Steelman
Linda S. Steelman
SASteve L. Abrams
Steve L. Abrams
LYLi Yang
Li Yang
Melchiorre CervelloMelchiorre Cervello
Melchiorre Cervello
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.

1 January 1988 in Journal of Steroid Biochemistry
Verified
Journal Article
Closed access
DGD. Giudici
D. Giudici
GOG. Ornati
G. Ornati
GBG. Briatico
G. Briatico
FBF. Buzzetti
F. Buzzetti
Paolo LombardiPaolo Lombardi
Paolo Lombardi
ESE. di Salle
E. di Salle

1 October 1997 in Pharmacology & Therapeutics
Verified
Journal Article
Closed access
FAFederico Arcamone
Federico Arcamone
FAFabio Animati
Fabio Animati
GCGiovanni Capranico
Giovanni Capranico
Paolo LombardiPaolo Lombardi
Paolo Lombardi
GPGraziella Pratesi
Graziella Pratesi
FZFranco Zunino
Franco Zunino

1 May 1996 in Tetrahedron: Asymmetry
Verified
Journal Article
Closed access
MBMaurizio Botta
Maurizio Botta
VSVincenzo Summa
Vincenzo Summa
FCFederico Corelli
Federico Corelli
GPGiovanna Di Pietro
Giovanna Di Pietro
Paolo LombardiPaolo Lombardi
Paolo Lombardi