Careful design of study plan is a key element of any successful educational program. Till 2018 Ministry of Health of Ukraine regulated the structure of Pharmacy study plans through the adoption of unified Ministerial study plan. Now the responsibility of educational programs and corresponding study plans design in Ukraine is fully transferred to universities. The purpose of this study is to compare the structure and content of pharmacy study plans in Visegrad Group countries with the most recent unified Pharmacy study plan in Ukraine. Methods. The official documents of Warsaw Medical University, Jagiellonian University in Krakow, Charles University, University of Veterinary and Pharmaceutical Sciences Brno, Comenius University, University of Veterinary Medicine and Pharmacy in Kosice, Semmelweis University and University of Debrecen were studied and data on required courses and corresponding ECTS credits extracted and compared with Ukrainian study plan. Results. Ukrainian unified study plan in Pharmacy pays much more attention to Humanity, Social and Economics section (9 ECTS credits plus 6 ECTS credits of Foreign Language), Computer and IT skills (8 ECTS credits), Hygiene and Ecology (3 ECTS credits), Life Safety, Labor Safety and Bioethics (6 ECTS credits in total), Extreme Medicine and Military Training (6 ECTS credits in total), Toxicological and Forensic Chemistry (4 ECTS credits), Organization and Economics of Pharmacy, Pharmaceutical Management and Marketing (12 ECTS credits in total) as compared to foreign universities. While natural science courses receive less ECTS credits in Ukraine, and some courses in rapidly evolving sciences like Molecular Biology, Immunology or Clinical Biochemistry are significantly underrepresented. Conclusions. The Pharmacy study plans of Visegrad Group universities show greater similarity with each other and tend to differ from the Ukrainian Ministerial study plan. The necessary steps to harmonize Pharmacy study plans of Ukrainian universities with V4 countries include the introduction of Molecular Biology, Immunology, Clinical Biochemistry courses, and strengthening the basic medical and chemical science courses like Human Anatomy and Physiology, Organic Chemistry, Analytical Chemistry, Pharmacology, Medicinal and Pharmaceutical Chemistry. Careful design of study plan is a key element of any successful educational program. Till 2018 Ministry of Health of Ukraine regulated the structure of Pharmacy study plans through the adoption of unified Ministerial study plan. Now the responsibility of educational programs and corresponding study plans design in Ukraine is fully transferred to universities. The purpose of this study is to compare the structure and content of pharmacy study plans in Visegrad Group countries with the most recent unified Pharmacy study plan in Ukraine. Methods. The official documents of Warsaw Medical University, Jagiellonian University in Krakow, Charles University, University of Veterinary and Pharmaceutical Sciences Brno, Comenius University, University of Veterinary Medicine and Pharmacy in Kosice, Semmelweis University and University of Debrecen were studied and data on required courses and corresponding ECTS credits extracted and compared with Ukrainian study plan. Results. Ukrainian unified study plan in Pharmacy pays much more attention to Humanity, Social and Economics section (9 ECTS credits plus 6 ECTS credits of Foreign Language), Computer and IT skills (8 ECTS credits), Hygiene and Ecology (3 ECTS credits), Life Safety, Labor Safety and Bioethics (6 ECTS credits in total), Extreme Medicine and Military Training (6 ECTS credits in total), Toxicological and Forensic Chemistry (4 ECTS credits), Organization and Economics of Pharmacy, Pharmaceutical Management and Marketing (12 ECTS credits in total) as compared to foreign universities. While natural science courses receive less ECTS credits in Ukraine, and some courses in rapidly evolving sciences like Molecular Biology, Immunology or Clinical Biochemistry are significantly underrepresented. Conclusions. The Pharmacy study plans of Visegrad Group universities show greater similarity with each other and tend to differ from the Ukrainian Ministerial study plan. The necessary steps to harmonize Pharmacy study plans of Ukrainian universities with V4 countries include the introduction of Molecular Biology, Immunology, Clinical Biochemistry courses, and strengthening the basic medical and chemical science courses like Human Anatomy and Physiology, Organic Chemistry, Analytical Chemistry, Pharmacology, Medicinal and Pharmaceutical Chemistry. Ґрунтовний підхід до складання навчальних планів є ключовим елементом будь-якої успішної освітньої програми. До 2018 року Міністерство охорони здоров'я України регулювало структуру навчальних планів з фармації шляхом прийняття єдиного примірного навчального плану на рівні Міністерства. На теперішній час відповідальність за розробку освітніх програм та відповідних навчальних планів в Україні повністю передано університетам. Метою цього дослідження є порівняння структури та змісту навчальних планів з фармації в країнах Вишеградської групи із останнім типовим навчальним планом з фармації в Україні. Методи. Для аналізу використовували офіційні документи Варшавського медичного університету, Ягеллонського університету в...

Chlorhexidine is an effective cationic antiseptic and disinfectant that has been used in medical practice for decades. It is generally recommended to use different concentrations of aqueous or alcoholic solutions of chlorhexidine for different therapeutic purposes. Objective. To determine the proportions of different chlorhexidine concentrations in medicines purchased by state and municipal organizations and to identify possible issue of chlorhexidine formulations utilization in the suboptimal or insufficient concentrations. Results. The vast majority of the chlorhexidine-containing medicines found in the State Register of Medicines of Ukraine are 0.05% solutions for external use, 0.05% gels for dental and urological use and vaginal suppositories (pessaries) with 16 mg of chlorhexidine in one dose. While the most common representatives of chlorhexidine-containing medicines abroad are solutions with a concentration of 4% and 2%, as well as mouthwashes with a concentration of 0.12%. The highest share - 96% - among the procurements of chlorhexidine-containing medicines by state and municipal organizations is 0.05% aqueous solution for external use. Instructions for medical use of 0.05% aqueous chlorhexidine solution for external use contain indications that are not supported by international documents: WHO Model List of Essential Medicines and British National Formulary. Conclusions. The obtained results suggest probable cases of irrational use of chlorhexidine medicines in medical practice in Ukraine. The consequences of such cases are not limited to the failure to achieve therapeutic goals or to the development of nosocomial infection, but includes also the selection of chlorhexidine-resistant strains of microorganisms. Key words: chlorhexidine; assortment analysis; medicinal procurements study; suboptimal concentration; rational pharmacotherapy

The Pharmacophore Model for the Antistaphylococcal Activity Screening Among Thiazolidinone-Related Structures

Background: The development of novel tubulin-targeting agents remains a promising strategy in anticancer drug design. In the present study, novel heterocyclic tubulin-targeting compounds were identified using a complex in silico/in vitro workflow. Methods: An in-house library of approximately 8000 structurally diverse heterocyclic compounds was screened for antiproliferative activity, yielding 260 experimentally validated hits. These compounds were docked against the colchicine, vinca, and taxane binding sites of tubulin. Selected compounds were also tested for their effects on cellular β-tubulin protein levels in Jurkat cells. Results: Docking analysis indicated that 42 compounds matched or exceeded colchicine’s binding energy, 3 compounds were comparable to vinblastine, and 18 compounds surpassed paclitaxel, suggesting the colchicine and taxane sites as preferred targets. Five top-scoring compounds (Les-6370, Les-4272, Les-4309, Les-4403, and Les-1419) were further analyzed via molecular dynamics simulations, confirming stable binding—particularly at the colchicine site—and favorable hydrogen-bonding and lipophilic interactions. At 10 µM, Les-1419 and Les-4309 reduced total cellular β-tubulin protein levels in Jurkat cells by 57.73% and 54.31%, respectively, relative to the effect observed for the reference compound Combretastatin A-4. Conclusions: This study resulted in the identification of novel starting scaffolds with favorable tubulin interaction activity and predicted drug-like properties, representing structurally novel parent structures and serving as promising starting points for further structural optimization and analogue development.