Dispersion characteristics of expiratory aerosols were investigated in an enclosure with two different idealized airflow patterns: the ceiling-return and the unidirectional downward. A multiphase numerical model, which was able to capture the polydispersity and evaporation features of the aerosols, was adopted. Experiments employing optical techniques were conducted in a chamber with downward airflow pattern to measure the dispersion of aerosols. Some of the numerical results were compared with the chamber measurement results. Reasonable agreement was found. Small aerosols (initial size