Alexander Shtil

Prof. Alexander Shtil

Blokhin Cancer Center and Institute of Gene Biology, Russian Academy of Sciences, 24 Kashirskoye shosse, 115478 Moscow, Russia
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Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2002 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
GCGabriela Chiosis
Gabriela Chiosis
BLBrian Lucas
Brian Lucas
ASAlexander Shtil
Alexander Shtil
HHHenri Huezo
Henri Huezo
NRNeal Rosen
Neal Rosen

14 January 1999 in Oncogene
Verified
Journal Article
Closed access
ASAlexander Shtil
Alexander Shtil
SMSandhya Mandlekar
Sandhya Mandlekar
RYRong Yu
Rong Yu
RWRobert J Walter
Robert J Walter
KHKaren Hagen
Karen Hagen
AKAh-Ng Tony Kong
Ah-Ng Tony Kong

21 July 2022 in Biomedicines
Verified
Journal Article
Open access
PDF file
AHAseel Ali Hasan
Aseel Ali Hasan
EKElena Kalinina
Elena Kalinina
VTVictor V. Tatarskiy
Victor V. Tatarskiy
ASAlexander Shtil
Alexander Shtil
Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS), which are produced as by-products of aerobic respiration. ROS play a significant role in cell homeostasis through redox signaling and are capable of eliciting damage to macromolecules. Multiple antioxidant defense systems have evolved to prevent dangerous ROS accumulation in the body, with the glutathione and thioredoxin/thioredoxin reductase (Trx/TrxR) systems being the most important. The Trx/TrxR system has been used as a target to treat cancer through the thiol–disulfide exchange reaction mechanism that results in the reduction of a wide range of target proteins and the generation of oxidized Trx. The TrxR maintains reduced Trx levels using NADPH as a co-substrate; therefore, the system efficiently maintains cell homeostasis. Being a master regulator of oxidation–reduction processes, the Trx-dependent system is associated with cell proliferation and survival. Herein, we review the structure and catalytic properties of the Trx/TrxR system, its role in cellular signaling in connection with other redox systems, and the factors that modulate the Trx system.

1 October 1996 in Cancer Letters
Verified
Journal Article
Closed access
RYRong Yu
Rong Yu
ASAlexander Shtil
Alexander Shtil
Tse-Hua TanTse-Hua Tan
Tse-Hua Tan
IRIgor B. Roninson
Igor B. Roninson
AKAh-Ng Tony Kong
Ah-Ng Tony Kong

16 November 2019 in Nanomaterials
Verified
Journal Article
Open access
PDF file
MDMarina S. Dukhinova
Marina S. Dukhinova
Artur Y. PrilepskiiArtur Y. Prilepskii
Artur Y. Prilepskii
ASAlexander Shtil
Alexander Shtil
VVVladimir Vinogradov
Vladimir Vinogradov
Macrophages are components of the innate immune system that control a plethora of biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes depending on the cue; however, polarization may be altered in bacterial and viral infections, cancer, or autoimmune diseases. Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. Macrophages can recognize and engulf nanoparticles, while the influence of macrophage-nanoparticle interaction on cell polarization remains unclear. In this review, we summarize the molecular mechanisms that drive macrophage activation phenotypes and functions upon interaction with nanoparticles in an inflammatory microenvironment. The manifold effects of metal oxide nanoparticles on macrophages depend on the type of metal and the route of synthesis. While largely considered as drug transporters, metal oxide nanoparticles nevertheless have an immunotherapeutic potential, as they can evoke pro- or anti-inflammatory effects on macrophages and become essential for macrophage profiling in cancer, wound healing, infections, and autoimmunity.

1 February 2009 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
VOValentina Ol'shevskaya
Valentina Ol'shevskaya
RNRoza G. Nikitina
Roza G. Nikitina
ASArina N. Savchenko
Arina N. Savchenko
MMMarina V. Malshakova
Marina V. Malshakova
AVAlexander M. Vinogradov
Alexander M. Vinogradov
ASAlexander Shtil
Alexander Shtil